期刊
ACS CATALYSIS
卷 6, 期 12, 页码 8214-8218出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.6b02541
关键词
rhodium; oxidation; amidation; hindered; amine; aniline
资金
- University of Illinois, Urbana-Champaign
- ACS PRF [54007-DNII]
- NSF [CAREER 1555337]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1555337] Funding Source: National Science Foundation
A rhodium-catalyzed oxidative amidation reaction has been developed with sterically hindered aldehydes and alcohols for the synthesis of amides containing a quaternary carbon at the alpha position. A variety of amine nucleophiles, both aliphatic and aromatic, are employed and afford the corresponding amides in good to excellent yields. Finally, mechanistic studies are performed to gain insight into both catalytic cycles.
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