期刊
ACS CATALYSIS
卷 6, 期 7, 页码 4248-4252出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.6b00678
关键词
arylation; catalysis; C-H activation; palladium; benzoxazole
资金
- CNRS
- Rennes Metropole
- French Scientific Ministry of Higher Education
We report herein, a very simple catalytic system for the direct arylation of benzoxazole and benzothiazole derivatives at C7 position, namely, phosphine-free PdCl2 associated with PivOK in NMP at 150 degrees C. (Thio)phenoxy chelation-assisted Pd-catalyzed C-H bond cleavage, from an opened intermediate, was proposed to explain this unique regioselectivity. This reaction allows the synthesis of 2-amino-6-arylphenols through the ring opening of the benzoxazole.
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