Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors

Results at 2 Years after Gene Therapy for RPE65-Deficient Leber Congenital Amaurosis and Severe Early-Childhood–Onset Retinal Dystrophy

(2016) Richard G. Weleber et al.   OPHTHALMOLOGY

Establishment of a cone photoreceptor transplantation platform based on a novel cone-GFP reporter mouse line

(2016) Sheila Smiley et al.   Scientific Reports

Long-Term Effect of Gene Therapy on Leber’s Congenital Amaurosis

(2015) James W.B. Bainbridge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transplantation of Photoreceptor Precursors Isolated via a Cell Surface Biomarker Panel from Embryonic Stem Cell-Derived Self-Forming Retina

(2015) Jorn Lakowski et al.   STEM CELLS

Gene therapy restores vision in rd1 mice after removal of a confounding mutation in Gpr179

(2015) Koji M. Nishiguchi et al.   Nature Communications

Cell fusion in the brain: two cells forward, one cell back

(2014) Kevin Kemp et al.   ACTA NEUROPATHOLOGICA

Advances in repairing the degenerate retina by rod photoreceptor transplantation

(2014) Rachael A. Pearson   BIOTECHNOLOGY ADVANCES

Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial

(2014) Robert E MacLaren et al.   LANCET

Daylight Vision Repair by Cell Transplantation

(2014) Tiago Santos-Ferreira et al.   STEM CELLS

Photoreceptor replacement therapy: Challenges presented by the diseased recipient retinal environment

(2014) RACHAEL A. PEARSON et al.   VISUAL NEUROSCIENCE

Derivation of Traceable and Transplantable Photoreceptors from Mouse Embryonic Stem Cells

(2014) Sarah Decembrini et al.   Stem Cell Reports

Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina

(2013) Anai Gonzalez-Cordero et al.   NATURE BIOTECHNOLOGY

Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation

(2013) M. S. Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Migration, Integration and Maturation of Photoreceptor Precursors Following Transplantation in the Mouse Retina

(2013) Katherine Warre-Cornish et al.   STEM CELLS AND DEVELOPMENT

Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication

(2013) Carsten Frühbeis et al.   PLOS BIOLOGY

Manipulation of the Recipient Retinal Environment by Ectopic Expression of Neurotrophic Growth Factors Can Improve Transplanted Photoreceptor Integration and Survival

(2012) E. L. West et al.   CELL TRANSPLANTATION

Restoration of vision after transplantation of photoreceptors

(2012) R. A. Pearson et al.   NATURE

Mitochondria to the rescue

(2012) Darwin J Prockop   NATURE MEDICINE

Outer Segment Formation of Transplanted Photoreceptor Precursor Cells

(2012) Dominic Eberle et al.   PLoS One

Repair of the degenerate retina by photoreceptor transplantation

(2012) A. C. Barber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defining the Integration Capacity of Embryonic Stem Cell-Derived Photoreceptor Precursors

(2012) Emma L. West et al.   STEM CELLS

Embryonic Stem Cell-Derived Neural Stem Cells Fuse with Microglia and Mature Neurons

(2012) Carlo Cusulin et al.   STEM CELLS

Robust cell integration from co-transplantation of biodegradable MMP2-PLGA microspheres with retinal progenitor cells

(2010) Jing Yao et al.   BIOMATERIALS

Quantitative Determination of Spatial Protein-Protein Correlations in Fluorescence Confocal Microscopy

(2010) Yong Wu et al.   BIOPHYSICAL JOURNAL

Targeted Disruption of Outer Limiting Membrane Junctional Proteins (Crb1 and ZO-1) Increases Integration of Transplanted Photoreceptor Precursors into the Adult Wild-Type and Degenerating Retina

(2010) R. A. Pearson et al.   CELL TRANSPLANTATION

Long-Term Survival of Photoreceptors Transplanted into the Adult Murine Neural Retina Requires Immune Modulation

(2010) Emma L. West et al.   STEM CELLS

Nuclear Architecture of Rod Photoreceptor Cells Adapts to Vision in Mammalian Evolution

(2009) Irina Solovei et al.   CELL

Transplantation of Human Embryonic Stem Cell-Derived Photoreceptors Restores Some Visual Function in Crx-Deficient Mice

(2009) Deepak A. Lamba et al.   Cell Stem Cell

Fusion of Hematopoietic Cells with Purkinje Neurons Does Not Lead to Stable Heterokaryon Formation under Noninvasive Conditions

(2009) C. Nern et al.   JOURNAL OF NEUROSCIENCE

A Novel Adeno-Associated Viral Variant for Efficient and Selective Intravitreal Transduction of Rat Müller Cells

(2009) Ryan R. Klimczak et al.   PLoS One

Retinal cells integrate into the outer nuclear layer and differentiate into mature photoreceptors after subretinal transplantation into adult mice

(2008) Udo Bartsch et al.   EXPERIMENTAL EYE RESEARCH

Pharmacological disruption of the outer limiting membrane leads to increased retinal integration of transplanted photoreceptor precursors

(2008) E.L. West et al.   EXPERIMENTAL EYE RESEARCH

Treatment of Leber Congenital Amaurosis Due to RPE65 Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results of a Phase I Trial

(2008) William W. Hauswirth et al.   HUMAN GENE THERAPY

Live imaging of mammalian retina: rod outer segments are stained by conventional mitochondrial dyes

(2008) Paolo Bianchini et al.   JOURNAL OF BIOMEDICAL OPTICS

Extensive fusion of haematopoietic cells with Purkinje neurons in response to chronic inflammation

(2008) Clas B. Johansson et al.   NATURE CELL BIOLOGY

Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis

(2008) Albert M. Maguire et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of Gene Therapy on Visual Function in Leber's Congenital Amaurosis

(2008) James W.B. Bainbridge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chondroitin Sulfate Proteoglycans and Microglia Prevent Migration and Integration of Grafted Müller Stem Cells into Degenerating Retina

(2008) Shweta Singhal et al.   STEM CELLS

Isolation of Progenitor Cells from GFP-Transgenic Pigs and Transplantation to the Retina of Allorecipients

(2008) Henry Klassen et al.   Cloning Stem Cells