Article
Cell Biology
Vanessa Hertig, Louis Villeneuve, Angelino Calderone
Summary: Fibroblast progenitor cells express nestin, and this intermediate filament protein may drive the migration of ventricular fibroblasts. The subpopulation of fibroblasts expressing nestin is refractory to cell cycle reentry, and nestin may preferentially facilitate the migration of ventricular fibroblasts during physiological/pathological remodeling.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Cell Biology
Ruping Wang, Sakeeb Khan, Guoning Liao, Yidi Wu, Dale D. Tang
Summary: This study found that nestin promotes the migration of smooth muscle cells by regulating Plk1 phosphorylation, which in turn regulates vimentin phosphorylation, the connection of vimentin filaments with paxillin, and focal adhesion assembly.
Article
Immunology
James J. Kadiri, Sina Tadayon, Keshav Thapa, Anni Suominen, Maija Hollmen, Petteri Rinne
Summary: MC1-R regulates hematopoietic stem cell proliferation and tissue leukocyte counts, but its deficiency in leukocytes impairs cell migration. Despite increased hematopoietic stem cells and leukocyte counts, atherosclerotic plaque size and composition are unaffected by MC1-R deficiency.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Timoteo Marchini, Lucia Sol Mitre, Dennis Wolf
Summary: Atherosclerosis is a chronic inflammatory disease initiated and maintained by leukocytes, which can lead to myocardial infarction and stroke. Challenges in developing therapies for leukocyte accumulation include the lack of tissue-tropism of targeted factors and unspecific inhibition strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yutang Wang, Dinh Tam Nguyen, Jack Anesi, Ahmed Alramahi, Paul K. Witting, Zhonglin Chai, Abdul Waheed Khan, Jason Kelly, Kate M. Denton, Jonathan Golledge
Summary: This study aimed to investigate the effect of the sympatholytic drug moxonidine on atherosclerosis. The results showed that moxonidine increased the uptake of oxidised LDL by vascular smooth muscle cells (VSMCs), as well as the expression of LDL receptors and the lipid efflux transporter ABCG1. Moxonidine also inhibited inflammatory gene expression and increased VSMC migration. In vivo experiments on ApoE(-/-) mice showed that moxonidine administration reduced atherosclerosis formation and increased plasma lipid hydroperoxide levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Alexandre Bergeron, Andra Brezai, Rami Shukr, Louis Villeneuve, Bruce G. Allen, Wasay M. S. Qureshi, Kathryn E. Hentges, Angelino Calderone
Summary: The study found that the appearance of nestin in neonatal rat ventricular cardiomyocytes was associated with a migratory phenotype, and the cotreatment with p38 mitogen-activated protein kinase inhibitor promoted the synthesis of nestin. Additionally, the reorganization of nonmuscle myosin IIB and its physical interaction with nestin may act together to facilitate the migratory phenotype in cardiomyocytes.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jacob Amersfoort, Frank H. Schaftenaar, Hidde Douna, Peter J. van Santbrink, Gijs H. M. van Puijvelde, Bram Slutter, Amanda C. Foks, Amy Harms, Estefania Moreno-Gordaliza, Yanyan Wang, Thomas Hankemeier, Ilze Bot, Hongbo Chi, Johan Kuiper
Summary: The study found that dyslipidemia affects the migration of Treg cells, leading to inadequate immunosuppression in atherosclerotic lesions. This condition alters the migration capacity and cellular metabolism of Treg cells, increasing their migration to lymphoid tissues and influencing infiltration into atherosclerotic lesions.
CARDIOVASCULAR RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Carina A. Valenzuela, Ella J. Baker, Elizabeth A. Miles, Philip C. Calder
Summary: Conjugated linoleic acid (CLA) isomers, specifically cis-9, trans-11 (CLA9,11) and trans-10, cis-12 (CLA10,12), have shown modest anti-inflammatory effects on endothelial cells (ECs) at low concentrations. These CLAs decrease the concentrations of inflammatory factors such as MCP-1, IL-6, IL-8, and RANTES in the culture medium, but also upregulate some pro-inflammatory genes while downregulating others. The findings suggest that CLAs may have a role in preventing atherosclerosis by modulating inflammation in ECs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Jonathan Edward Dawson, Tina Sellmann, Katrin Porath, Rainer Bader, Ursula van Rienen, Revathi Appali, Rudiger Koehling
Summary: This article investigates the migration of human osteoblasts in a direct current electric field and proposes a computational model to describe this process. The results show that cell-cell interactions and fluctuations in the migration direction promote collective migration of osteoblasts.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Plant Sciences
Liang Luo, Huiying Liang, Luoying Liu
Summary: The study found that myristicin plays a role in regulating the proliferation and apoptosis of human vascular smooth muscle cells and umbilical vein endothelial cells, and this effect is achieved by regulating the PI3K/Akt/NF-kappa B signaling pathway. Myristicin may be a new potential drug for AS treatment.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Carina A. Valenzuela, Ella J. Baker, Elizabeth A. Miles, Philip C. Calder
Summary: Conjugated linoleic acid (CLA) isomers have different effects on the inflammatory responses of endothelial cells (ECs). CLA10,12 exhibits pro-inflammatory effects while CLA9,11 shows null or anti-inflammatory effects. Therefore, it is necessary to evaluate the effects of each CLA isomer independently.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Xiaobing Liang, Wanbing He, Hua Zhang, Dongling Luo, Zhengzhipeng Zhang, Aiting Liu, Jinkai Wang, Hui Huang
Summary: This study identifies an inflammatory macrophage-like subpopulation of VSMCs and suggests that MMP9 plays a key role in the phenotypic transition of VSMCs. Additionally, it is found that RELA regulates MMP9 expression and that serum MMP9 levels correlate significantly with the inflammatory response, providing a potential new target for early treatment of VC.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Weifeng Li, Jinjin Yu, Xin Xiao, Wenqi Li, Lulu Zang, Tengfei Han, Dezhu Zhang, Xiaofeng Niu
Summary: The study found that ECG can inhibit VSMCs proliferation and migration, reduce cholesterol levels and oxidative stress by regulating inflammation, cell cycle, and gene expression pathways, suggesting potential clinical applications in preventing atherosclerosis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Analytical
Ayana Yamagishi, Fumie Ito, Chikashi Nakamura
Summary: Chloride channels regulate cell volume by efflux of chloride ions in response to osmotic stresses, and this ability is correlated with the metastatic potential of cancer cells, serving as a potential indicator for estimating their invasion ability.
ANALYTICAL CHEMISTRY
(2021)
Article
Cell Biology
Yajing Diao
Summary: The study showed that Clematichinenoside AR (AR) has beneficial effects on atherosclerosis by promoting cholesterol efflux, inhibiting foam cell formation and inflammation through regulating autophagy.
Article
Biochemistry & Molecular Biology
Laura Valls-Lacalle, Lidia Puertas-Umbert, Saray Varona, Jose Martinez-Gonzalez, Cristina Rodriguez, Antonio Rodriguez-Sinovas
Summary: Although transgenic mice over-expressing human LOX in the heart show higher baseline myocardial oxidative stress, our study demonstrates that there were no significant differences in ROS production, infarct size, or post-infarction cardiac remodeling during myocardial ischemia-reperfusion.
Article
Cardiac & Cardiovascular Systems
Gonzalo Baron-Esquivias, Macarena Quintanilla, Antonio J. Diaz-Martin, Carmen Baron-Solis, Carmen V. Almeida-Gonzalez, Carmen Garcia-Romero, Inmaculada Paneque, Carmen Rubio-Guerrero, Rosario Rodriguez-Corredor, Juan I. Valle-Racero, Antonio Ordonez, Carlos A. Morillo
Summary: This study analyzed the long-term outcome of patients with syncope after exclusion of a cardiac cause. The study found that the recurrence rate after 52 months of follow-up was 37.4% and the annual mortality rate was 6.6%. Patients with a neuromedial profile had a higher recurrence rate, while patients with a nonneuromedial profile had a higher mortality rate.
REVISTA ESPANOLA DE CARDIOLOGIA
(2022)
Article
Medicine, Research & Experimental
Isabel Mayoral-Gonzalez, Eva M. Calderon-Sanchez, Isabel Galeano-Otero, Marta Martin-Bornez, Encarnacion Gutierrez-Carretero, Maria Fernandez-Velasco, Nieves Domenech, Maria Generosa Crespo-Leiro, Ana Maria Gomez, Antonio Ordonez-Fernandez, Abdelkrim Hmadcha, Tarik Smani
Summary: Ucn-2 has been found to exert cardioprotective effects through the regulation of miR-29a, reducing fibrosis and apoptosis caused by myocardial I/R injury. Furthermore, elevated expression of Hmox-1 in the ventricle of ischemic patients with heart failure was observed, which was inversely correlated with left ventricle ejection fraction.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Cardiac & Cardiovascular Systems
Raquel Del Toro, Isabel Galeano-Otero, Elisa Bevilacqua, Francisco Guerrero-Marquez, Debora Falcon, Agustin Guisado-Rasco, Luis Diaz-de la Llera, Gonzalo Baron-Esquivias, Tarik Smani, Antonio Ordonez-Fernandez
Summary: This study investigated the role of pro-inflammatory cell populations, related cytokines, and miRNAs as prognostic biomarkers for left ventricular adverse remodeling (LVAR) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). The findings suggest that the combined analysis of intermediate monocytes, vascular endothelial growth factor (VEGF), and miRNAs can predict the development of LVAR in STEMI patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Geriatrics & Gerontology
Miriam Diez-Diez, Marta Amoros-Perez, Jorge de la Barrera, Enrique Vazquez, Ana Quintas, Domingo A. Pascual-Figal, Ana Dopazo, Fatima Sanchez-Cabo, Monica E. Kleinman, Leslie B. Gordon, Valentin Fuster, Vicente Andres, Jose J. Fuster
Summary: Clonal hematopoiesis of indeterminate potential (CHIP), the presence of somatic mutations in cancer-related genes in blood cells without hematological cancer, is an important risk factor for age-related conditions, especially cardiovascular disease. It is unknown whether CHIP plays a role in premature aging syndromes. Hutchinson-Gilford progeria syndrome (HGPS) is an ultra-rare genetic condition characterized by accelerated aging. This study investigated the prevalence of CHIP in HGPS patients and found that it is not frequent in HGPS, suggesting that it is unlikely to contribute to the pathophysiology of this accelerated aging syndrome.
Article
Cell Biology
Guillermo L. Lehmann, Michael Ginsberg, Daniel J. Nolan, Cristina Rodriguez, Jose Martinez-Gonzalez, Shemin Zeng, Andrew P. Voigt, Robert F. Mullins, Shahin Rafii, Enrique Rodriguez-Boulan, Ignacio Benedicto
Summary: A2M, a protease inhibitor, is found to be expressed in endothelial cells of the human eye choroid. The expression of A2M is induced by retinal pigment epithelium (RPE)-conditioned medium, with VEGF-A playing a key role. Furthermore, the inhibition of A2M leads to the restoration of gelatinase activity in culture supernatants. This study provides important insights into the alterations in choroidal ECM and visual function due to dysfunctional RPE or choroidal blood vessels.
Article
Peripheral Vascular Disease
Lucia Diaz S. del Campo, Ana B. Garcia-Redondo, Cristina Rodriguez, Carlos Zaragoza, Santiago Duro-Sanchez, Francesco Palmas, Angela de Benito-Bueno, Paula G. Socuellamos, Diego A. Peraza, Raquel Rodrigues-Diez, Carmen Valenzuela, Jesmond Dalli, Mercedes Salaices, Ana M. Briones
Summary: The study found that there is an imbalance between proinflammatory and resolution mediators in hypertensive patients. Resolvin D2 (RvD2) protects cardiovascular function and structure both as a preventive measure before the development of hypertension and as a treatment for established hypertensive cardiovascular damage, by modulating vascular factors, reducing fibrosis and inflammation.
Article
Cardiac & Cardiovascular Systems
Fatima Sanchez-Cabo, Valentin Fuster, Juan Carlos Silla-Castro, Gema Gonzalez, Erika Lorenzo-Vivas, Rebeca Alvarez, Sergio Callejas, Alberto Benguria, Eduardo Gil, Estefania Nunez, Belen Oliva, Jose Maria Mendiguren, Marta Cortes-Canteli, Hector Bueno, Vicente Andres, Jose Maria Ordovas, Leticia Fernandez-Friera, Antonio J. Quesada, Jose Manuel Garcia, Xavier Rossello, Jesus Vazquez, Ana Dopazo, Antonio Fernandez-Ortiz, Borja Ibanez, Jose Javier Fuster, Enrique Lara-Pezzi
Summary: This study aims to assess the association between subclinical atherosclerosis and accelerated epigenetic age and investigate the underlying mechanisms. The presence, extension, and progression of subclinical atherosclerosis in healthy individuals were found to be associated with a significant acceleration of the Grim epigenetic age, regardless of traditional cardiovascular risk factors. Transcriptomics and proteomics data suggested the involvement of pro-inflammatory pathways and genes in mediating the association between subclinical atherosclerosis and epigenetic age acceleration.
EUROPEAN HEART JOURNAL
(2023)
Article
Engineering, Environmental
Joan Canals, Alba Cabrera-Codony, Oriol Carbo, Josefina Toran, Maria Martin, Merce Baldi, Belen Gutierrez, Manel Poch, Antonio Ordonez, Hector Monclus
Summary: Reducing SRT in HRAS processes maximizes energy recovery by minimizing COD oxidation. This study operated a pilot plant with an automatic control strategy to ensure stability and high COD removal at very low SRT. Factors such as temperature, influent and MLSS concentration were investigated for their effects on sCOD, cCOD and pCOD removal.
Article
Nutrition & Dietetics
Ana Isabel Reyes-Dominguez, Javier Bernabeu-Sendra, Cristina Rodriguez-Sinovas, Alicia Santamaria-Orleans, Roser de Castellar-Sanso, Jorge Martinez-Perez
Summary: In the last decade, feeding patterns, especially among children, have become worse, affecting their dietary habits and adherence to the Mediterranean diet. This study examines the feeding habits of Spanish toddlers after the pandemic. A survey was conducted with 2465 parents of children aged 12 to 36 months, revealing that only 1.38% of children had an adequate intake of all food groups. Compliance with dietary guidelines decreased as toddlers grew older. Factors such as higher fast food consumption, having siblings, and being the second or third child were associated with lower adherence.
Review
Cell Biology
Maria Gonzalez-Amor, Beatriz Dorado, Vicente Andres
Summary: Population aging and age-related cardiovascular disease (CVD) are widespread and burdensome worldwide. Cellular stress responses play a crucial role in the complex regulation and interaction between aging and CVD. The ubiquitin-like protein ISG15 and its pathway have been found to have implications in age-related telomere shortening, genomic instability, DNA damage accumulation, as well as in major CVD risk factors prevalent in the elderly population such as hypertension, diabetes, and obesity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Medicine, General & Internal
Jeanette A. Maier, Vicente Andres, Sara Castiglioni, Alessandro Giudici, Emily S. Lau, Janos Nemcsik, Francesca Seta, Paola Zaninotto, Mariella Catalano, Naomi M. Hamburg
Summary: Vascular aging predicts cardiovascular events and mortality, early assessment allows identification of at-risk individuals, and more studies are needed to develop strategies for prevention and treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Oncology
Livia E. Lisi-Vega, Simon Mendez-Ferrer
Summary: Although inflammation has been recognized as a characteristic feature of many cancers, its impact on individual cells in the tumor microenvironment and their interaction with normal and cancer cells is not fully understood. A single-cell transcriptomic analysis of bone marrow from AML patients and healthy individuals revealed that AML skews stem cell and stromal cell populations towards a proinflammatory state, which reduces the risk of relapse. This finding aligns with previous studies in mouse models and suggests that inflamed bone marrow mesenchymal stromal cells may have a dual role in AML by impairing normal hematopoiesis while also making AML cells more susceptible to chemotherapy or immune attack.
BLOOD CANCER DISCOVERY
(2023)
Article
Biochemistry & Molecular Biology
Alberto Del Monte-Monge, Inigo Ruiz-Polo de Lara, Pilar Gonzalo, Carla Espinos-Estevez, Maria Gonzalez-Amor, Miguel de la Fuente-Perez, Maria J. Andres-Manzano, Victor Fanjul, Juan R. Gimeno, Roberto Barriales-Villa, Beatriz Dorado, Vicente Andres
Summary: Mutations in the LMNA gene can cause various cardiac diseases, including dilated cardiomyopathies. In order to investigate the potential vascular alterations in LMNA-DCM, researchers generated mice without lamin A/C in vascular smooth muscle cells, cardiac fibroblasts, and cardiomyocytes. These mice exhibited similar clinical features to human LMNA-DCM, including cardiac dysfunction and fibrosis, as well as vascular phenotypic alterations. This study provides the first evidence of vascular defects contributing to the pathophysiology of LMNA-DCM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Alvaro Macias, Rosa M. Nevado, Cristina Gonzalez-Gomez, Pilar Gonzalo, Maria Jesus Andres-Manzano, Beatriz Dorado, Ignacio Benedicto, Vicente Andres
Summary: HGPS is a rare genetic disease caused by expression of progerin. This disease leads to pathological alterations in the coronary and cerebral arteries, and the mechanisms behind it involve loss of vascular smooth muscle cells and overexpression of K(V)7 channels. The study suggests that targeting K(V)7 channels could be a potential treatment for HGPS.