Article
Medicine, General & Internal
Ioannis A. Voutsadakis
Summary: This study investigates ER-positive/HER2-negative or luminal breast cancers with high mutation numbers and compares them with cancers of the same subtype and low mutation numbers. The results show that breast cancers with high mutation numbers have a higher prevalence of certain genetic mutations and DNA damage response genes. However, the prognosis of these breast cancers is not significantly different compared to those with lower mutation counts. These findings provide information on the suitability of these cancers for immunotherapy and potential combination therapies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Cristina Ferreira Almeida, Natercia Teixeira, Maria Joao Valente, Anne Marie Vinggaard, Georgina Correia-da-Silva, Cristina Amaral
Summary: Estrogen receptor-positive (ER+) breast cancer accounts for 70-85% of cases and combining CBD with aromatase inhibitors (AIs) may improve treatment effectiveness. CBD potentiates the anti-tumor effects of exemestane (Exe) by modulating cell death and specific targets such as ERa and AR. This study highlights the potential benefits of combining CBD with Exe and suggests new therapeutic approaches using cannabinoids.
Article
Oncology
Amir Sonnenblick, Dominique Agbor-tarh, Evandro de Azambuja, Susanne Hultsch, Miguel Izquierdo, Minetta Liu, Giancarlo Pruneri, Nadia Harbeck, Martine Piccart, Alvaro Moreno-Aspita, Roy Zvi Granit, Ghizlane Rouas, Ibrahim Fahoum, Christos Sotiriou
Summary: The study found that activated STAT3 serves as a favorable prognostic marker for disease-free survival in ER-positive breast cancer patients. However, there was no significant difference in overall survival outcomes.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Yunfeng Ding, Yonghong Liu, Dong-Kee Lee, Zhangwei Tong, Xiaobin Yu, Yi Li, Yong Xu, Rainer B. Lanz, Bert W. O'Malley, Jianming Xu
Summary: This study reveals that ERα*RFP*Erbb2* cells progressively lose ERα during tumorigenesis to become highly metastatic, and these ERα*origin breast cancers are more aggressive.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Tushar Singh Barwal, Uttam Sharma, Sonali Bazala, Ipsa Singh, Manju Jain, Hridayesh Prakash, Shashank Shekhar, Elise N. Sandberg, Anupam Bishayee, Aklank Jain
Summary: The article discusses the use of aromatase inhibitors in breast and ovarian cancers, as well as the potential role of noncoding RNAs (including miRNAs and lncRNAs) in modulating cancer hallmarks and overcoming drug resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hasan Al-Kelabi, Dunya Al-Duhaidahawi, Khattab Al-Khafaji, Najim A. Al-Masoudi
Summary: A new class of tamoxifen analogues was synthesized using McMurry reaction conditions. The analogues showed potent activity against MCF-7 breast cancer cells, with compound 10 exhibiting the highest activity against aromatase. Docking studies showed that the new compounds had good correlations with experimental IC50, suggesting their potential as starting scaffolds for designing efficient drugs against estrogen receptor and aromatase.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Oncology
Yuxin Xie, Libo Yang, Yanqi Wu, Hong Zheng, Qiheng Gou
Summary: The study found that AI/T + AI combination endocrine therapy may be a reasonable treatment option for ER-low positive breast cancer patients, and treatment duration of more than 3 years is associated with better disease-free survival.
Article
Oncology
Tao Qing, Thomas Karn, Mariya Rozenblit, Julia Foldi, Michal Marczyk, Naing Lin Shan, Kim Blenman, Uwe Holtrich, Kevin Kalinsky, Funda Meric-Bernstam, Lajos Pusztai
Summary: The RxPONDER and TAILORx trials showed the benefits of adjuvant chemotherapy in patients under 50 with positive lymph nodes and Recurrence Score (RS) 0-26, and in node-negative disease with RS 16-25. However, no benefits were observed in older women with the same clinical features. Transcriptomic and genomic data analysis revealed that younger patients had lower mRNA expression of ESR1 and ER-associated genes, higher expression of immune-related genes, and a different mutation burden compared to older patients.
Article
Health Care Sciences & Services
Taobo Hu, Yan Chen, Yiqiang Liu, Danhua Zhang, Jiankang Pan, Mengping Long
Summary: The loss of PR expression in ER+/HER2- breast cancers indicates a worse prognosis and insensitivity to anti-estrogen therapy. Various PR expression statuses in these cancers can be indicative of molecular variation, particularly in relation to the activation of growth factor pathways.
BMC MEDICAL RESEARCH METHODOLOGY
(2021)
Review
Oncology
Jing Xu, Bo Cao, Chunyu Li, Guohui Li
Summary: Breast cancer is a global health concern. Endocrine therapy is crucial in treating estrogen-positive breast cancer, but it often leads to osteoporosis-related adverse events. These events increase the risk of fractures and reduce the patients' quality of life. This review explores the possibility of endocrine therapy-induced osteoporosis in estrogen-positive breast cancer treatment and discusses the mechanisms involved and the potential of drug therapies and combinations.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Fei Fei, Gene P. Siegal, Shi Wei
Summary: The study analyzed clinicopathologic features and clinical outcomes of ER-low-positive breast cancers. ER-low-positive tumors showed significantly better prognosis compared to ER-negative tumors, with overlapping survival outcomes with ER-positive tumors in the entire cohort.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Chemistry, Medicinal
Lilan Xin, Jian Min, Hebing Hu, Yuanyuan Li, Chuanqian Du, Baohua Xie, Yan Cheng, Xiaofei Deng, Xiangping Deng, Kang Shen, Jian Huang, Chun -Chi Chen, Rey-Ting Guo, Chune Dong, Hai -Bing Zhou
Summary: In this study, a novel class of dual-targeting selective estrogen receptor degraders (SERDs) based on a three-dimensional oxabicycloheptene sulfonamide (OBHSA) scaffold equipped with aromatase inhibitor (AI) activity were identified. These compounds showed excellent ERa degradation activity, ARO inhibitory activity, and antiproliferative activity against drug-resistant breast cancer cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Oncology
Reema S. Wahdan-Alaswad, Susan M. Edgerton, Hiba Salem, Hyun Min Kim, Aik Choon Tan, Jessica Finlay-Schultz, Elizabeth A. Wellberg, Carol A. Sartorius, Britta M. Jacobsen, Bryan R. Haugen, Bolin Liu, Ann D. Thor
Summary: The study revealed clinically significant adverse interactions between THRT, estrogenic, and oncogenic signaling in patients with steroid receptor-positive, lymph node-negative breast cancer.
CLINICAL CANCER RESEARCH
(2021)
Article
Chemistry, Medicinal
Zhenlin Liang, Lijuan Liu, Yanyu Zhou, Wukun Liu, Yunlong Lu
Summary: Breast cancer, the most prevalent cancer in women, has been treated with endocrine therapy drugs, such as tamoxifen, since 1977. However, drug resistance and side effects remain challenges in the treatment of ER+ breast cancer. Metal complexes, particularly platinum complexes, have shown promising antitumor activities and may provide new opportunities for the treatment of ER+ breast cancer.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Cristina Ferreira Almeida, Natercia Teixeira, Ana Oliveira, Tiago Augusto, Georgina Correia-da-Silva, Maria Joao Ramos, Pedro Alexandrino Fernandes, Cristina Amaral
Summary: Breast cancer remains the leading cause of cancer-related death in women worldwide, with a need for the development of novel therapies for estrogen receptor-positive breast cancer. Multi-target compounds have emerged as promising therapeutic strategies for this subtype of breast cancer due to their ability to modulate several important targets simultaneously.
Article
Mathematical & Computational Biology
Shu Jiang, Jiguo Cao, Graham A. Colditz, Bernard Rosner
Summary: With mammography as the primary screening strategy for breast cancer, it is important to utilize mammogram imaging data to identify women at different risk levels. This study proposes a supervised functional principal component analysis method for extracting features from mammogram images, which improves prediction accuracy. The method effectively addresses the irregular boundary issue and shows better performance compared to unsupervised methods in simulation studies.
Article
Biology
Shu Jiang, Jiguo Cao, Bernard Rosner, Graham A. Colditz
Summary: Screening mammography is a method to detect breast cancer early, and it measures breast density to predict future cancer risk. This article introduces flexible methods, supervised FPCA and functional partial least squares, to extract image-based features associated with failure time while considering right censoring. The proposed methods outperform benchmark models in terms of prediction performance and reveal different risk patterns within mammograms.
Article
Oncology
Tuo Lan, Yikyung Park, Graham A. Colditz, Jingxia Liu, Molin Wang, Kana Wu, Edward Giovannucci, Siobhan Sutcliffe
Summary: While the results were not entirely consistent, the study found that a high plant-based dietary pattern during adolescence may be associated with a slightly reduced risk of prostate cancer.
BRITISH JOURNAL OF CANCER
(2023)
Article
Dermatology
Lauren K. Shea, Neal S. Akhave, Leslie A. Sutton, Leigh A. Compton, Conner York, Sai Mukund Ramakrishnan, Christopher A. Miller, Lukas D. Wartman, David Y. Chen
Summary: Cutaneous squamous cell carcinoma (cSCC) has a high mutation burden, mainly due to UV light exposure. KDM6A is frequently mutated in cSCC and acts as a tumor suppressor. In mice, the deficiency of both Kdm6a and Trp53 leads to spontaneous cSCC development, with recurrent mutations found in Ncstn and Vcan.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Oncology
Ruiyi Tian, Brian Wiley, Jie Liu, Xiaoyu Zong, Buu Truong, Stephanie Zhao, Md Mesbah Uddin, Abhishek Niroula, Christopher A. Miller, Semanti Mukherjee, Brendan T. Heiden, Jingqin Luo, Varun Puri, Benjamin D. Kozower, Matthew J. Walter, Li Ding, Daniel C. Link, Christopher Amos, Benjamin L. Ebert, Ramaswamy Govindan, Pradeep Natarajan, Kelly L. Bolton, Yin Cao
Summary: This study prospectively examined the association between clonal hematopoiesis (CH) and subsequent risk of lung cancer. It found that CH is independently associated with increased risk of lung cancer, regardless of known risk factors.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Health Care Sciences & Services
Thabani Nyoni, Emily C. Evers, Maria Perez, Donna B. Jeffe, Stephanie A. Fritz, Graham A. Colditz, Jason P. Burnham
Summary: This study explores the barriers and facilitators to implementing tele-ID consults at rural hospitals in southeastern Missouri. The study identifies logistical, technological, emotional, and legal challenges as barriers to adoption, while perceived need, benefits, flexibility, and prior experiences are facilitators. The findings highlight the potential of tele-ID consults to address healthcare gaps and improve access to infectious disease consultations in underserved communities.
JOURNAL OF TELEMEDICINE AND TELECARE
(2023)
Editorial Material
Oncology
Graham A. Colditz
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Jennifer Berrian, Ying Liu, Nkiruka Ezenwajiaku, Alvaro Moreno-Aspitia, Sara J. J. Holton, Adetunji T. T. Toriola, Graham A. A. Colditz, Ashley J. J. Housten, Lannis Hall, Mark A. A. Fiala, Foluso O. O. Ademuyiwa
Summary: The COVID-19 pandemic did not significantly exacerbate racial disparities in late-stage presentation of breast, colorectal, lung, and prostate cancers.
Article
Oncology
Elizabeth A. A. Salerno, Rohana Gao, Jason Fanning, Neha P. P. Gothe, Lindsay L. Peterson, Allison B. B. Anbari, Maura M. M. Kepper, Jingqin Luo, Aimee S. S. James, Edward McAuley, Graham A. A. Colditz
Summary: This study investigated the preferences and needs of rural cancer survivors for home-based physical activity programs. The majority of the participants reported daily internet access. Computer/laptop and mobile phone were the most preferred delivery modes, and balance/flexibility exercises were preferred. The findings highlight the importance of personalization in designing and delivering home-based interventions.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Mary Beth Terry, Graham A. Colditz
Summary: Research methods for studying risk factors and prevention of breast cancer have rapidly advanced. This review focuses on epidemiological studies over the past two decades, summarizing scientific discoveries and their translation into clinical practice and public health interventions for reducing breast cancer risk. The review highlights the importance of timing of exposure and susceptibility windows and discusses the implications of recent evidence for risk stratification models and clinical translation to maximize prevention benefits and minimize harm.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
(2023)
Article
Oncology
Shu Jiang, Debbie L. Bennett, Bernard A. Rosner, Graham A. Colditz
Summary: This study found that the rate of change in breast density was associated with the risk of subsequent breast cancer. Incorporation of longitudinal changes into existing models could optimize risk stratification and guide more personalized risk management.
Article
Medicine, Research & Experimental
David Y. Chen, Leslie A. Sutton, Sai Mukund Ramakrishnan, Eric J. Duncavage, Sharon E. Heath, Leigh A. Compton, Christopher A. Miller, Timothy J. Ley
Summary: Alterations in epigenetic regulators are increasingly recognized as early events in tumorigenesis. Patients with acquired or inherited variants in epigenetic regulators may be at increased risk for developing multiple types of cancer. We report the case of an adult DOS patient with a germline DNMT3A loss-of-function mutation, who developed an early-onset melanoma with regional lymph node metastatic disease. Exome sequencing of the primary tumor identified an additional acquired, missense DNMT3A mutation in the dominant tumor clone, suggesting that the loss of DNMT3A function was relevant for the development of this tumor.
COLD SPRING HARBOR MOLECULAR CASE STUDIES
(2023)
Meeting Abstract
Oncology
Yao-Chi Yu, Mei Wang, Akhil Kumar, Kristin Vargo, Lawrence Liu, Theodore Thomas, Kristen Sanfilippo, Martin Schoen, Graham Colditz, Jr-Shin Li, Su-Hsin Chang
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Meeting Abstract
Oncology
Sydney Beache, Michelle Silver, Jingxia Liu, Aimee James, Graham Colditz, Courtney Harriss
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Meeting Abstract
Oncology
Kyle Cottrell, Pat Kung, Sua Ryu, Leonard Maggi, Catherine Kuzmicki, Raleigh Kladney, Ling Yiu, Graham Colditz, Jason D. Weber
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)