Article
Endocrinology & Metabolism
Qinli Liu, Sen Zhao, Jian Zhou, Ping Liu, Bo Huo
Summary: This study found that continuous microvibration stimulation can significantly improve the parthenogenetic developmental potential of human immature oocytes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Xia Hao, Jessie Phoon, Lina Barbunopulos, Mona Sheikhi, Arturo Reyes Palomares, Kenny A. Rodriguez-Wallberg
Summary: The study investigated the developmental potential of mature metaphase II (MII) human oocytes obtained from germinal vesicle oocytes (GVs) after rescue in vitro maturation (rIVM) and the impact of vitrification at different timepoints. Results showed that the likelihood of obtaining MII oocytes was slightly higher in the fresh rIVM group compared to the vitrification-warming-rIVM group. However, the fertilization and developmental rates were reduced in both groups that underwent vitrification either before or after rIVM.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Pawel Kordowitzki, Gabriela Sokolowska, Marta Wasielak-Politowska, Agnieszka Skowronska, Mariusz T. Skowronski
Summary: The oocyte plays a crucial role in embryo development, with cell-to-cell and cell-to-matrix communications being key for oocyte's developmental competence. Pannexins and Connexins are families of channels that are important for various physiological and pathological processes related to oocyte development and fertility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Genetics & Heredity
Qing Sang, Zhou Zhou, Jian Mu, Lei Wang
Summary: This review outlines the genetic determinants of abnormalities in human oocyte maturation, fertilization, and early embryonic development, identifying 16 genes that may cause oocyte maturation arrest, fertilization failure, and embryonic lethality. These genetic markers lay the foundation for individualized genetic counseling and potential treatments in reproductive medicine.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Multidisciplinary Sciences
Sai-Li Liu, Hai-Yang Zuo, Bing-Wang Zhao, Jia-Ni Guo, Wen-Bo Liu, Wen-Long Lei, Yuan-Yuan Li, Ying-Chun Ouyang, Yi Hou, Zhi-Min Han, Wei-Zhou Wang, Qing-Yuan Sun, Zhen-Bo Wang
Summary: In this study, a novel heterozygous missense mutation in ZP2 was identified in a primary infertile female. The mutation was shown to reduce ZP2 expression and impede ZP2 secretion in cell lines. A mouse model with the mutation was constructed and it was found that the mutation caused degeneration of oocytes without zona pellucida (ZP) and resulted in complete infertility. ZP deletion also impaired folliculogenesis and caused female infertility in this mouse model. This study expands the spectrum of ZP2 mutation sites and increases the understanding of pathogenic mechanisms of ZP2 mutations.
Review
Environmental Sciences
Juanmei Gao, Wanhua Shen
Summary: The Xenopus model is advantageous for studying embryo development and developmental toxicity, as well as human diseases. It has been successfully used to study various diseases, including fetal alcohol spectrum disorders, autism, epilepsy, and cardiovascular disease. Xenopus also has potential applications in genetic and chemical screening.
ENVIRONMENTAL POLLUTION
(2021)
Article
Cell Biology
Mingrui Li, Chao Ren, Shuai Zhou, Yuanlin He, Yueshuai Guo, Hao Zhang, Lu Liu, Qiqi Cao, Congjing Wang, Jie Huang, Yue Hu, Xue Bai, Xuejiang Guo, Wenjie Shu, Ran Huo
Summary: The study found that abnormal expression of splicing regulation proteins in aged oocytes affects the splicing of DNA repair-related genes in 2-cell embryos, reducing their developmental potential.
Article
Obstetrics & Gynecology
Alvaro Martinez-Moro, Leopoldo Gonzalez-Brusi, Ana Querejeta-Fernandez, Ester Padilla-Ruiz, Javier Garcia-Blanco, Pablo Bermejo-lvarez
Summary: This study found that the abundance of malonate, 5-oxyproline, and erythronate in human cumulus cells (CCs) was positively associated with oocyte quality, providing insights into the metabolic pathways required for oocyte competence.
HUMAN REPRODUCTION
(2023)
Review
Genetics & Heredity
Alessandro Bartolacci, Giulia Intra, Giovanni Coticchio, Miriam dell'Aquila, Gilda Patria, Andrea Borini
Summary: This study aims to investigate the impact of oocyte dysmorphisms on the outcomes of assisted reproduction treatments based on the existing scientific literature. Eleven different dysmorphisms were identified, and the COC morphology, vacuoles, SER clusters, and granularity were found to be predominantly associated with negative outcomes.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Endocrinology & Metabolism
Hui Li, Huan Wang, Jing Zhu, Jianmin Xu, Yuqing Jiang, Wenhui Chen, Yingpu Sun, Qingling Yang
Summary: This study aimed to assess the impact of female BMI on DNA repair ability in oocytes after fertilization. It found that overweight women had lower embryo quality and reproductive outcomes when fertilized with sperm with high DNA fragmentation. The decreased DNA repair activity in oocytes may explain the low early development potential of embryos in overweight patients during in vitro fertilization cycles.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Md Wasim Bari, Yoshiya Morishita, Satoshi Kishigami
Summary: In this study, two types of nucleolar morphology were observed in mouse in vitro fertilized embryos at the four-cell stage: single nucleolus (SN) and multiple nucleoli (MN). Further analysis revealed that embryos with single nucleolus had a higher developmental potential, as indicated by a higher rate of blastocyst formation and offspring production. These embryos also showed a higher number of NANOG-positive cells at the blastocyst stage.
ANIMAL SCIENCE JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Udayanga Sanath Kankanam Gamage, Shu Hashimoto, Yuki Miyamoto, Tatsuya Nakano, Masaya Yamanaka, Akiko Koike, Manabu Satoh, Yoshiharu Morimoto
Summary: This study investigates the supplementation of autologous adipose stem cell mitochondria in vitrified and warmed oocytes and finds that this supplementation can restore damaged mitochondrial quality and enhance embryo developmental capacity.
Article
Reproductive Biology
Juan Carlos Gutierrez-Anez, Andrea Lucas-Hahn, Klaus-Gerd Hadeler, Patrick Aldag, Heiner Niemann
Summary: The study found that adding melatonin during in vitro culture can improve cumulus-oocyte competence and embryo development in prepubertal and adult dairy cattle, enhancing embryo quality.
Article
Obstetrics & Gynecology
Antonio Capalbo, Silvia Buonaiuto, Matteo Figliuzzi, Gianluca Damaggio, Laura Girardi, Silvia Caroselli, Maurizio Poli, Cristina Patassini, Murat Cetinkaya, Beril Yuksel, Ajuna Azad, Marie Louise Grondahl, Eva R. Hoffmann, Carlos Simon, Vincenza Colonna, Semra Kahraman
Summary: This study identified new and known genes associated with infertility through case selection and whole-exome sequencing analysis, providing important clues for further research.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Medicine, General & Internal
Yun-Qiao Dong, Chuang-Qi Chen, Yu-Qiang Huang, Dun Liu, Xi-Qian Zhang, Feng-Hua Liu
Summary: In this study, the effect of sperm on the developmental potential of in vitro-matured oocytes in conventional culture was investigated. The rates of in vitro oocyte maturation, normal fertilization, normal cleavage, day-3 top-quality embryos, and useful blastocyst formation were compared between the old sperm group and the fresh sperm group.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Materials Science, Multidisciplinary
Hossein Vahid Alizadeh, Michael Fanton, David B. Camarillo
Summary: This paper presents a novel shock absorption system based on woven fabrics designed to fully collapse and absorb energy at a near-minimum force level. The system exerts an approximately constant force across different impact velocities and has an average efficiency far above standard foams. Its potential applications include soft devices for space-constrained applications such as contact sport helmets.
JOURNAL OF INTELLIGENT MATERIAL SYSTEMS AND STRUCTURES
(2022)
Article
Engineering, Biomedical
Samuel J. Raymond, Nicholas J. Cecchi, Hossein Vahid Alizadeh, Ashlyn A. Callan, Eli Rice, Yuzhe Liu, Zhou Zhou, Michael Zeineh, David B. Camarillo
Summary: This work presents a new physics-informed machine learning model for analyzing kinematic data and detecting impacts to the head. By simulating head impacts and creating a large synthetic dataset, the model achieves improved performance compared to traditional impact detectors. It shows the best results to date for impact detection in American football.
ANNALS OF BIOMEDICAL ENGINEERING
(2022)
Review
Obstetrics & Gynecology
Fang Fang, Phillip J. Iaquinta, Ninuo Xia, Lei Liu, Lei Diao, Renee A. Reijo Pera
Summary: This article discusses the important role of transcription factors in reproductive development, focusing specifically on the transcriptional mechanisms of human reproductive development. By studying the transcriptional network components of human germ cells, deeper insights into human infertility and reproductive disorders can be gained, potentially contributing to the development of novel treatments for infertility.
HUMAN REPRODUCTION UPDATE
(2022)
Article
Multidisciplinary Sciences
Samuel J. Raymond, Sam Baker, Yuzhe Liu, Mauricio J. Bustamante, Brett Ley, Michael J. Horzewski, David B. Camarillo, David N. Cornfield
Summary: Most critically ill patients with COVID-19 experience respiratory failure, leading to critical shortages in the supply of mechanical ventilators. In response to this, a low-cost, high-performance ventilator has been designed using medical gases and flow interruption strategy, which has received emergency use authorization from the FDA and can be used in clinical settings.
Article
Biotechnology & Applied Microbiology
Zhou Zhou, Xiaogai Li, August G. Domel, Emily L. Dennis, Marios Georgiadis, Yuzhe Liu, Samuel J. Raymond, Gerald Grant, Svein Kleiven, David Camarillo, Michael Zeineh
Summary: Hippocampal injury is common in traumatic brain injury patients, and this study found that the adjacent fluid-containing temporal horn may exacerbate the vulnerability of the hippocampus. The presence of the temporal horn was associated with increased strain and strain rate in the hippocampus, indicating a mechanobiological dependency of the hippocampus on the temporal horn.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Xianghao Zhan, Yiheng Li, Yuzhe Liu, Nicholas J. Cecchi, Olivier Gevaert, Michael M. Zeineh, Gerald A. Grant, David B. Camarillo
Summary: This study investigates the relationship between brain strain and kinematic features in different types of head impacts. The researchers used a data-driven approach and found piecewise multivariate linearity between cumulative strain damage (CSDM) and head kinematic features. They compared different partition methods and found that the K-means clustering method showed significantly higher regression accuracy for CSDM. The study suggests that this method may contribute to the rapid prediction of CSDM in the future.
ANNALS OF BIOMEDICAL ENGINEERING
(2022)
Article
Engineering, Biomedical
Xianghao Zhan, Yuzhe Liu, Nicholas J. Cecchi, Olivier Gevaert, Michael M. Zeineh, Gerald A. Grant, David B. Camarillo
Summary: The study utilized principal component analysis (PCA) to analyze the spatial co-variation of injury metrics in four types of head impacts, aiding in the improvement of the machine learning head model (MLHM). PCA-MLHM reduced model parameters by 74% with comparable MPS estimation accuracy.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Correction
Engineering, Biomedical
Nicholas J. Cecchi, August G. Domel, Yuzhe Liu, Eli Rice, Rong Lu, Xianghao Zhan, Zhou Zhou, Samuel J. Raymond, Sohrab Sami, Heer Singh, India Rangel, Landon P. Watson, Svein Kleiven, Michael Zeineh, David B. Camarillo, Gerald Grant
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Nicholas J. Cecchi, Ashlyn A. Callan, Landon P. Watson, Yuzhe Liu, Xianghao Zhan, Ramanand V. Vegesna, Collin Pang, Enora Le Flao, Gerald A. Grant, Michael M. Zeineh, David B. Camarillo
Summary: This study evaluated the impact attenuation capabilities of a padded helmet shell cover in both laboratory and field settings. The results showed that the padded helmet shell cover effectively reduced the magnitude of angular head accelerations and brain injury risk metrics in laboratory tests. However, no significant differences in head impact magnitude were observed between wearing the padded helmet shell cover and not wearing it in field tests. This research supports the need for in vivo helmet research to validate laboratory testing results.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Clinical Neurology
Mahta Karimpoor, Marios Georgiadis, Moss Y. Zhao, Maged Goubran, Hossein Moein Taghavi, Brian D. Mills, Dean Tran, Nicole Mouchawar, Sohrab Sami, Max Wintermark, Gerald Grant, David B. Camarillo, Michael E. Moseley, Greg Zaharchuk, Michael M. Zeineh
Summary: Long-term exposure to head impacts in high-contact sports can lead to changes in cerebral blood flow, with an initial increase followed by a decrease over time. This study highlights the importance of understanding the relationship between sports and brain injury.
ANNALS OF NEUROLOGY
(2023)
Article
Hospitality, Leisure, Sport & Tourism
Xianghao Zhan, Yiheng Li, Yuzhe Liu, Nicholas J. Cecchi, Samuel J. Raymond, Zhou Zhou, Hossein Vahid Alizadeh, Jesse Ruan, Saeed Barbat, Stephen Tiernan, Olivier Gevaert, Michael M. Zeineh, Gerald A. Grant, David B. Camarillo
Summary: This study investigated the spectral characteristics of different head impact types using kinematics classification. The machine-learning-based classifier showed high accuracy in classifying head impact types, and different types of impacts had different distributions of spectral densities in low- and high-frequency ranges. This research contributes to a better understanding of impact kinematics in different sports.
JOURNAL OF SPORT AND HEALTH SCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Nicholas J. Cecchi, Hossein Vahid Alizadeh, Yuzhe Liu, David B. Camarillo
Summary: Concerns have been raised regarding the long-term effects of head impacts and concussions in American football. This study explores the potential of liquid shock absorbers in improving helmet safety performance. Results show that the liquid helmet model significantly reduces impact forces compared to existing helmet models and has lower brain strains. The findings suggest the promising ability of liquid shock absorbers in mitigating brain injury risk.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Clinical Neurology
Maged Goubran, Brian David Mills, Marios Georgiadis, Mahta Karimpoor, Nicole Mouchawar, Sohrab Sami, Emily Larson Dennis, Carolyn Akers, Lex Mitchell, Brian Boldt, David Douglas, Phillip Scott Digiacomo, Jarrett Rosenberg, Gerald Grant, Max Wintermark, David Benjamin Camarillo, Michael Zeineh
Summary: This study investigated longitudinal changes in brain microstructure of high-contact (football) and low-contact (volleyball) collegiate athletes using advanced diffusion MRI. It found significant differences in microstructural metrics and tracts between football and volleyball players, especially in concussed football players. The findings suggest alterations in white matter development in football athletes due to concussive and repeated subconcussive impacts.
Meeting Abstract
Sport Sciences
Nicholas J. Cecchi, Ashlyn A. Callan, Landon P. Watson, Yuzhe Liu, Xianghao Zhan, Michael M. Zeineh, Gerald A. Grant, David B. Camarillo
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Meeting Abstract
Critical Care Medicine
Xianghao Zhan, Yuzhe Liu, Olivier Gevaert, Michael Zeineh, David Camarillo
JOURNAL OF NEUROTRAUMA
(2022)