期刊
NATURE COMMUNICATIONS
卷 7, 期 -, 页码 -出版社
NATURE RESEARCH
DOI: 10.1038/ncomms10580
关键词
-
资金
- Swiss National Science Foundation (SNF) [31003A_146265/1]
- Novartis foundation
- State of Fribourg
- EMBO long-term fellowship
- Swiss National Science Foundation (SNF) [31003A_146265] Funding Source: Swiss National Science Foundation (SNF)
The circadian system has endowed animals with the ability to anticipate recurring food availability at particular times of day. As daily food anticipation ( FA) is independent of the suprachiasmatic nuclei, the central pacemaker of the circadian system, questions arise of where FA signals originate and what role components of the circadian clock might play. Here we show that liver-specific deletion of Per2 in mice abolishes FA, an effect that is rescued by viral overexpression of Per2 in the liver. RNA sequencing indicates that Per2 regulates beta-hydroxybutyrate (beta OHB) production to induce FA leading to the conclusion that liver Per2 is important for this process. Unexpectedly, we show that FA originates in the liver and not in the brain. However, manifestation of FA involves processing of the liver-derived beta OHB signal in the brain, indicating that the food-entrainable oscillator is not located in a single tissue but is of systemic nature.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据