Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

Fine-Scale Mapping of the 5q11.2 Breast Cancer Locus Reveals at Least Three Independent Risk Variants Regulating MAP3K1

(2015) Dylan M. Glubb et al.   AMERICAN JOURNAL OF HUMAN GENETICS

TOX3 is expressed in mammary ER+ epithelial cells and regulates ER target genes in luminal breast cancer

(2015) Akop Seksenyan et al.   BMC CANCER

Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk

(2015) S. P. Kar et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2

(2015) N. Orr et al.   HUMAN MOLECULAR GENETICS

Identification of six new susceptibility loci for invasive epithelial ovarian cancer

(2015) Karoline B Kuchenbaecker et al.   NATURE GENETICS

CAUSEL: an epigenome- and genome-editing pipeline for establishing function of noncoding GWAS variants

(2015) Sándor Spisák et al.   NATURE MEDICINE

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

(2015) Melina Claussnitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Senescent Fibroblasts Promote Neoplastic Transformation of Partially Transformed Ovarian Epithelial Cells in a Three-dimensional Model of Early Stage Ovarian Cancer

(2015) Kate Lawrenson et al.   NEOPLASIA

In vivo metabolite profiling as a means to identify uncharacterized lipase function: Recent success stories within the alpha beta hydrolase domain (ABHD) enzyme family

(2014) Gwynneth Thomas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation

(2014) Maya Ghoussaini et al.   Nature Communications

Comprehensive Functional Annotation of 77 Prostate Cancer Risk Loci

(2014) Dennis J. Hazelett et al.   PLoS Genetics

Functional Variants at the 11q13 Risk Locus for Breast Cancer Regulate Cyclin D1 Expression through Long-Range Enhancers

(2013) Juliet D. French et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Fine-Scale Mapping of the FGFR2 Breast Cancer Risk Locus: Putative Functional Variants Differentially Bind FOXA1 and E2F1

(2013) Kerstin B. Meyer et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Integrative eQTL-Based Analyses Reveal the Biology of Breast Cancer Risk Loci

(2013) Qiyuan Li et al.   CELL

Genome-wide association studies identify four ER negative–specific breast cancer risk loci

(2013) Montserrat Garcia-Closas et al.   NATURE GENETICS

GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer

(2013) Paul D P Pharoah et al.   NATURE GENETICS

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

(2013) Stig E Bojesen et al.   NATURE GENETICS

Large-scale genotyping identifies 41 new loci associated with breast cancer risk

(2013) Kyriaki Michailidou et al.   NATURE GENETICS

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31

(2013) Jennifer Permuth-Wey et al.   Nature Communications

Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer

(2013) Hui Shen et al.   Nature Communications

Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

(2013) Fergus J. Couch et al.   PLoS Genetics

Matrix eQTL: ultra fast eQTL analysis via large matrix operations

(2012) A. A. Shabalin   BIOINFORMATICS

Fast and accurate inference of local ancestry in Latino populations

(2012) Yael Baran et al.   BIOINFORMATICS

Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA)

(2012) N. Mavaddat et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Common Variants at the 19p13.1 and ZNF365 Loci Are Associated with ER Subtypes of Breast Cancer and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

(2012) F. J. Couch et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

19p13.1 Is a Triple-Negative-Specific Breast Cancer Susceptibility Locus

(2012) K. N. Stevens et al.   CANCER RESEARCH

Evaluation of Association Methods for Analysing Modifiers of Disease Risk in Carriers of High-Risk Mutations

(2012) Daniel R. Barnes et al.   GENETIC EPIDEMIOLOGY

A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11

(2012) Afshan Siddiq et al.   HUMAN MOLECULAR GENETICS

The long-range interaction landscape of gene promoters

(2012) Amartya Sanyal et al.   NATURE

Breast cancer risk–associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression

(2012) Richard Cowper-Sal·lari et al.   NATURE GENETICS

Genome-wide association analysis identifies three new breast cancer susceptibility loci

(2012) Maya Ghoussaini et al.   NATURE GENETICS

Primary culture and immortalization of human fallopian tube secretory epithelial cells

(2012) Alison M Karst et al.   Nature Protocols

Patterns of Cis Regulatory Variation in Diverse Human Populations

(2012) Barbara E. Stranger et al.   PLoS Genetics

Common Breast Cancer Susceptibility Loci Are Associated with Triple-Negative Breast Cancer

(2011) K. N. Stevens et al.   CANCER RESEARCH

LIN28B Polymorphisms Influence Susceptibility to Epithelial Ovarian Cancer

(2011) J. Permuth-Wey et al.   CANCER RESEARCH

Modelling genetic and clinical heterogeneity in epithelial ovarian cancers

(2011) Kate Lawrenson et al.   CARCINOGENESIS

NBA1/MERIT40 and BRE Interaction Is Required for the Integrity of Two Distinct Deubiquitinating Enzyme BRCC36-containing Complexes

(2011) Xin Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

(2011) H. W. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phenotypic robustness conferred by apparently redundant transcriptional enhancers

(2010) Nicolás Frankel et al.   NATURE

A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24

(2010) Ellen L Goode et al.   NATURE GENETICS

Common variants at 19p13 are associated with susceptibility to ovarian cancer

(2010) Kelly L Bolton et al.   NATURE GENETICS

A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population

(2010) Antonis C Antoniou et al.   NATURE GENETICS

MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks

(2009) G. Shao et al.   GENES & DEVELOPMENT

NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control

(2009) B. Wang et al.   GENES & DEVELOPMENT

A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2

(2009) Honglin Song et al.   NATURE GENETICS

Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2

(2009) Shahana Ahmed et al.   NATURE GENETICS

A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies

(2009) Bryan N. Howie et al.   PLoS Genetics