期刊
NATURE COMMUNICATIONS
卷 7, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms13453
关键词
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资金
- National Key Research and Development Plan of China [2016YFA0502600]
- National Natural Science Foundation of China [81422036, 31470855, J1310025]
- Guangdong Natural Science Funds for Distinguished Young Scholar [S2013050014639]
- Foundation for the Author of National Excellent Doctoral Dissertation of PR China [201230]
- Guangdong Province Higher Vocational Colleges & Schools Pearl River Scholar Funded Scheme
- Fundamental Research Funds for the Central Universities [15lgjc09]
B cells are prominent components of human solid tumours, but activation status and functions of these cells in human cancers remain elusive. Here we establish that over 50% B cells in hepatocellular carcinoma (HCC) exhibit an Fc gamma RIIlow/- activated phenotype, and high infiltration of these cells positively correlates with cancer progression. Environmental semimature dendritic cells, but not macrophages, can operate in a CD95L-dependent pathway to generate Fc gamma RIIlow/- activated B cells. Early activation of monocytes in cancer environments is critical for the generation of semimature dendritic cells and subsequent Fc gamma RIIlow/- activated B cells. More importantly, the activated Fc gamma RIIlow/- B cells from HCC tumours, but not the resting Fc gamma RIIhigh B cells, without external stimulation suppress autologous tumour-specific cytotoxic T-cell immunity via IL-10 signals. Collectively, generation of Fc gamma RIIlow/- activated B cells may represent a mechanism by which the immune activation is linked to immune tolerance in the tumour milieu.
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