期刊
NATURE COMMUNICATIONS
卷 7, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms13827
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资金
- Universite Paris-Sud's Attractivite program
- CNRS' PEPS-PTI program
- Marie Curie Integration Grant [PCIG12-GA-2012-334053]
- 'Investissements d'Avenir' LabEx PALM [ANR-10-LABX-0039-PALM]
- ANR Grant [ANR-15-CE13-0004-03]
- ERC Starting Grant [677532]
- European Research Council (ERC) [677532] Funding Source: European Research Council (ERC)
The actin cytoskeleton is a key component in the machinery of eukaryotic cells, and it self-assembles out of equilibrium into a wide variety of biologically crucial structures. Although the molecular mechanisms involved are well characterized, the physical principles governing the spatial arrangement of actin filaments are not understood. Here we propose that the dynamics of actin network assembly from growing filaments results from a competition between diffusion, bundling and steric hindrance, and is responsible for the range of observed morphologies. Our model and simulations thus predict an abrupt dynamical transition between homogeneous and strongly bundled networks as a function of the actin polymerization rate. This suggests that cells may effect dramatic changes to their internal architecture through minute modifications of their nonequilibrium dynamics. Our results are consistent with available experimental data.
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