Article
Multidisciplinary Sciences
Diana Monsivais, Takashi Nagashima, Renata Prunskaite-Hyyrylainen, Kaori Nozawa, Keisuke Shimada, Suni Tang, Clark Hamor, Julio E. Agno, Fengju Chen, Ramya P. Masand, Steven L. Young, Chad J. Creighton, Francesco J. DeMayo, Masahito Ikawa, Se-Jin Lee, Martin M. Matzuk
Summary: The study reveals that bone morphogenetic proteins control endometrial receptivity in mice through the ACVR2A and SMAD1/5 signaling pathway, with ACVR2B being dispensable during embryo implantation.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Yi-Wei Wang, Shu-Chuan Chen, De-Leung Gu, Yi-Chen Yeh, Jhih-Jie Tsai, Kuo-Tai Yang, Yuh-Shan Jou, Teh-Ying Chou, Tang K. Tang
Summary: The study investigates the expression levels of centriolar/centrosomal genes in various types of cancers and identifies STIL as a protein that is highly expressed in lung and other types of cancers. Depletion of STIL inhibits tumor growth and metastasis, while excess STIL activates the EMT pathway and enhances cancer cell migration and invasion. The study reveals an unexpected role of STIL in tumor metastasis and identifies its association with FOXM1 in promoting metastasis and stemness.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jun Liu, Jipeng Li, Ke Wang, Haiming Liu, Jianyong Sun, Xinhui Zhao, Yanping Yu, Yihuan Qiao, Ye Wu, Xiaofang Zhang, Rui Zhang, Angang Yang
Summary: The study revealed a strong positive correlation between the expression levels of FoxM1 and STMN1 in various types of cancer, showing that FoxM1 promotes cell proliferation by upregulating STMN1 through transcriptional regulation. High levels of FoxM1 and STMN1 were associated with poor prognosis in solid tumors, with a high co-expression of both showing a more significant correlation with poor prognosis. The findings suggest that the FoxM1-STMN1 axis contributes to cell proliferation and tumorigenesis in hepatocellular carcinoma, gastric cancer, and colorectal cancer, making the combination of FoxM1 and STMN1 a potential biomarker for prognostic prediction.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Dan Yi, Bin Liu, Ting Wang, Qi Liao, Maggie M. Zhu, You-Yang Zhao, Zhiyu Dai
Summary: This study identified a novel mechanism of endothelial autocrine signaling in regulating PVEC proliferation and pulmonary vascular remodeling in PAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Wanning Liu, Boda Wang, Mingzhen Zhou, Dan Liu, Fulin Chen, Xiaodi Zhao, Yuanyuan Lu
Summary: Redox dysregulation leads to ROS accumulation, causing oxidative stress and cellular damage. ROS play a dual role in cancer development and survival. Recent studies have shown that ROS impact the behavior of cancer cells and tumor-associated stromal cells in the TME, and these cells have developed complex systems to adapt to high ROS environments.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Oncology
Tai-Lin Huang, Chuang-Rung Chang, Chih-Yen Chien, Gong-Kai Huang, Yi-Fan Chen, Li-Jen Su, Hsin-Ting Tsai, Yu-Sheng Lin, Fu-Min Fang, Chang-Han Chen
Summary: The study found that upregulation of DRP1 in head and neck cancer tissues is associated with poor patient prognosis; The mechanisms by which DRP1 affects HNC development include influencing aerobic glycolysis by regulating glycolytic genes and modulating FOXM1 and MMP12 expression; miR-575 can suppress DRP1 expression by targeting its mRNA.
MOLECULAR ONCOLOGY
(2022)
Article
Cell Biology
Yongming Jiang, Hui Zhao, Yuxiao Chen, Kangjian Li, Tianjie Li, Jianheng Chen, Baiyu Zhang, Caifen Guo, Liangliang Qing, Jihong Shen, Xiaodong Liu, Peng Gu
Summary: Exosomal lncRNA HOXD-AS1 is upregulated in CRPC and metastatic PCa, promoting cancer cell metastasis by modulating the miR-361-5p/FOXM1 axis. Serum exosomal HOXD-AS1 is correlated with disease characteristics and survival outcomes, serving as a potential liquid biopsy biomarker for metastatic PCa detection and treatment guidance.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Zhipeng Jiang, Hao Hu, Wenli Hu, Zehui Hou, Wei Liu, Zhuomin Yu, Zhiqiang Liang, Shuang Chen
Summary: This study aimed to investigate the role of circ-RNF121 in colorectal cancer (CRC). The results showed that circ-RNF121 silencing inhibited cell proliferation, migration, invasion, and glycolysis while inducing cell apoptosis in CRC. Additionally, circ-RNF121 acted as a sponge for miR-1224-5p and was involved in tumor growth inhibition in vivo. This finding sheds new light on circRNA-mediated therapy for CRC.
CANCER CELL INTERNATIONAL
(2021)
Article
Chemistry, Multidisciplinary
Iroda Saydullaeva, Bilge Debelec Butuner, Kemal Sami Korkmaz
Summary: Studies have shown that inflammation plays a role in the development and spread of aggressive prostate tumors, but the exact mechanism of how inflammation contributes to prostate cancer is still unclear. Previous research has indicated that the loss of tumor suppressor NKX3.1 is partially correlated with cell migration in response to conditioned media. This study investigates the role of inflammation in prostate cancer cell migration and the involvement of NKX3.1 in this process.
Article
Chemistry, Multidisciplinary
Iroda Saydullaeva, Bilge Debelec Butuner, Kemal Sami Korkmaz
Summary: Inflammation plays a synergistic role in the development and metastatic spread of aggressive prostate tumors. However, the exact mechanism by which inflammation promotes prostate cancer remains unclear. This study used the CRISPR/Cas9 system to suppress the expression of the tumor suppressor gene NKX3.1 and observed phenotypic changes in cell migration. Furthermore, quantitative proteomic analysis revealed that different cell subpopulations exhibited distinct phenotypes and genetic compositions during the process of cellular migration.
Article
Oncology
Jinlu Ma, Mengjiao Cai, Yaqi Mo, Joshua S. Fried, Xinyue Tan, Yuan Ma, Jie Chen, Suxia Han, Bo Xu
Summary: Prostate cancer is a leading cause of cancer-related deaths in men, and mutations in the SPOP gene have been linked to clinical stage and metastasis of the disease. The interaction between SPOP and ITCH plays a key role in prostate cancer metastasis, with SPOP mutations disrupting this interaction and leading to increased levels of ITCH protein and higher cell invasion potential.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
YuFeng Jiang, HaiMin Zhang, Wei Li, Yang Yan, XuDong Yao, WenYu Gu
Summary: The study revealed that LINC01426 is highly expressed in ccRCC and promotes tumor formation through the FOXM1 pathway. Additionally, LINC01426 exacerbates ccRCC progression by affecting the miR-423-5p/FOXM1 signaling pathway.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Zhenquan Lu, Jian Hou, Xiao Li, Jun Zhou, Bingfeng Luo, Richard K. Lo, Tak Man Wong, Guan-Ming Kuang, Guan-Ming Kuang
Summary: The study aimed to identify potential exosome-derived miRNAs related to prostate cancer bone metastasis. Two datasets were collected and analyzed to identify differentially expressed miRNAs. The study identified four miRNAs that may serve as biomarkers for prostate cancer bone metastasis. However, further research is needed to understand the role of these miRNAs in the development and progression of bone metastasis in prostate cancer.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Medicine, General & Internal
Zhuo Gao, Jannan Jiang, Lijian Hou, Bin Zhang
Summary: This study reveals the upregulation of RNF187 in colorectal cancer (CRC) and its association with poor prognosis. Inhibition of RNF187 expression suppresses the proliferation, migration, and invasion while promoting apoptosis of CRC cells. miR-144-5p is identified as a direct target of RNF187, and its downregulation in CRC tissues is negatively correlated with RNF187 expression. Restoration of miR-144-5p significantly inhibits CRC cell progression, which can be abolished by overexpression of RNF187.
JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE
(2022)
Article
Environmental Sciences
Pengcheng Zhao, Pengli Han, Yan Ma, Pei Tian, Jing Li
Summary: This study reveals that circ_0082878 promotes prostate cancer progression by regulating the miR-455-3p/WTAP signaling pathway, suggesting its potential as a therapeutic target for prostate cancer.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Developmental Biology
Hsiu-Chi Lee, Shih-Chieh Lin, Meng-Hsing Wu, Shaw-Jenq Tsai
Summary: The study identified that NTRK2 is upregulated in endometriotic lesions and its expression is induced by hypoxia through hypoxia-inducible factor 1 alpha. Treatment with NTRK2 antagonist ANA-12 induced cell death in endometriotic stromal cells and caused regression of ectopic lesions in a mouse model. These findings suggest a potential therapeutic target for endometriosis.
Review
Developmental Biology
Wan-Ning Li, Meng-Hsing Wu, Shaw-Jenq Tsai
Summary: Endometriosis is a benign gynecological disease affecting approximately 10% of women of reproductive age, leading to symptoms such as dysmenorrhea, dyspareunia, and infertility. Hypoxia plays a critical role in the disease phenotypes of endometriosis, influencing factors such as adhesion ability, estrogen biosynthesis, proinflammatory cytokines, angiogenic ability, and immune functions. Targeting HIF and downstream effectors may offer potential therapeutic options for endometriosis treatment.
Article
Cell Biology
Yi-Shyun Lai, Ya-Han Chang, Yong-Yi Chen, Jixuan Xu, Chi-Sian Yu, Su-Jing Chang, Pai-Sheng Chen, Shaw-Jenq Tsai, Wen-Tai Chiu
Summary: This study demonstrates the integral role of Ca2+ signals in cell biology, and optogenetic technology can be used to modulate Ca2+ waves and activate specific signaling pathways to explore the regulation of cell migration.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Neurosciences
Issa Olakunle Yusuf, Hsiu-Mei Chen, Pei-Hsun Cheng, Chih-Yi Chang, Shaw-Jenq Tsai, Jih-Ing Chuang, Chia-Ching Wu, Bu-Miin Huang, H. Sunny Sun, Chuan-Mu Chen, Shang-Hsun Yang
Summary: Proper development of neuronal cells is crucial for brain functions, and impairment may lead to disorders. Studies suggest that FGF9 may enhance total neuronal length through upregulation of NF-kB signaling in Huntington's disease (HD), potentially serving as a neuroprotective mechanism.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Issa Olakunle Yusuf, Hsiu-Mei Chen, Pei-Hsun Cheng, Chih-Yi Chang, Shaw-Jenq Tsai, Jih-Ing Chuang, Chia-Ching Wu, Bu-Miin Huang, H. Sunny Sun, Chuan-Mu Chen, Shang-Hsun Yang
Summary: This study demonstrates the importance of the ERK pathway in FGF9-induced neurite outgrowth in HD striatal models. Suppression of ERK signaling inhibits neurite outgrowth, cytoskeletal markers, and synaptic proteins, as well as NF-kB activation induced by FGF9. These findings suggest a sequential activation mechanism where FGF9 first activates the ERK signaling pathway, leading to NF-kB upregulation and subsequent enhancement of neurite outgrowth in HD striatal cells.
Letter
Dermatology
C. -b. Chu, C. -c. Yang, S. -j. Tsai
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Review
Medicine, Research & Experimental
Chu-An Wang, Shaw-Jenq Tsai
Summary: This article discusses the two pathways of cancer metastasis, particularly through the lymphatic system, and how cancer cells regulate this process through extracellular vesicle-dependent lymphangiogenesis.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Oncology
Chu-An Wang, Chien-Feng Li, Rho-Chi Huang, Yo-Hua Li, Jing-Ping Liou, Shaw-Jenq Tsai
Summary: The study showed that a selective HDAC1/2 inhibitor (B390) has multifaceted therapeutic potential in PDAC by restoring the expression and function of DUSP2. In vitro experiments demonstrated that B390 inhibited growth and migration abilities of PDAC cells, decreased VEGF-C expression, and suppressed lymphatic endothelial cell proliferation.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Cell Biology
Yu-Ying Chao, Bu-Miin Huang, I-Chen Peng, Pei-Rong Lee, Yi-Shyun Lai, Wen-Tai Chiu, Yi-Syuan Lin, Shih-Chieh Lin, Jung-Hsuan Chang, Pai-Sheng Chen, Shaw-Jenq Tsai, Chia-Yih Wang
Summary: Loss of primary cilia is associated with chemoresistance in pancreatic ductal adenocarcinoma (PDAC). Disruption of primary ciliogenesis sensitizes PDAC cells to cisplatin treatment, indicating a potential therapeutic strategy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Obstetrics & Gynecology
Shih-Chieh Lin, Wan-Ning Li, Shin-Chih Lin, Haun-Tzu Hou, Ya-Chuan Tsai, Tin-Chien Lin, Meng-Hsing Wu, Shaw-Jenq Tsai
Summary: YAP1 inhibition can alleviate progesterone resistance in endometriosis. Through in vitro and in vivo experiments, it has been found that YAP1 inhibition can reduce progesterone resistance. It is known that progesterone resistance not only causes treatment failure for endometriosis but also inhibits eutopic endometrial cell proliferation, dysregulates decidualization, and reduces the success rates of pregnancy.
HUMAN REPRODUCTION
(2023)
Article
Cell Biology
Yi-Shyun Lai, Cheng-Chi Chang, Yong-Yi Chen, Thi My Hang Nguyen, Jixuan Xu, Ying-Chi Chen, Yu-Fen Chang, Chia-Yih Wang, Pai-Sheng Chen, Shih-Chieh Lin, I-Chen Peng, Shaw-Jenq Tsai, Wen-Tai Chiu
Summary: In this study, the effects of optogenetically engineered Ca2+ signaling on mitochondrial dynamics were investigated. It was found that customized illumination conditions could trigger specific signaling pathways by generating unique Ca2+ oscillation waves. Modulating Ca2+ oscillations through increasing light frequency, intensity, and exposure time resulted in mitochondrial fission, dysfunction, autophagy, and cell death. The phosphorylation of the mitochondrial fission protein DRP1 at the Ser616 residue was activated by Ca2+-dependent kinases CaMKII, ERK, and CDK1, but not at Ser637. Calcineurin phosphatase was not activated by optogenetically engineered Ca2+ signaling to dephosphorylate DRP1 at Ser637. Furthermore, light illumination had no effect on the expression levels of the mitochondrial fusion proteins MFN1 and MFN2.
JOURNAL OF CELL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Pei -Ling Hsu, Chun -Wei Chien, Yen-An Tang, Bo -Wen Lin, Shih-Chieh Lin, Yi-Syuan Lin, Sih-Yu Chen, H. Sunny Sun, Shaw-Jenq Tsai
Summary: Metastasis is the main cause of death in many cancers including colorectal cancer (CRC), but the underlying mechanisms are largely unknown. This study found that the nuclear TYRO3 receptor tyrosine kinase is a strong predictor of poor overall survival in patients with CRC. The function of nuclear TYRO3 in promoting metastasis requires its kinase activity and MMP-2-mediated cleavage, independent of ligand binding. The research also identified BRD3 as one of nuclear TYRO3's substrates and demonstrated that TYRO3-phosphorylated BRD3 regulates genes involved in anti-apoptosis and epithelial-mesenchymal transition.
Editorial Material
Biochemistry & Molecular Biology
Huan-Tzu Hou, Ting-Chien Lin, Meng-Hsing Wu, Shaw-Jenq Tsai
Summary: Recent research has found that Fusobacterium nucleatum, a Gram-negative anaerobic bacterium, is present in the uterus of 64% of women with endometriosis. This bacterium infection leads to macrophage infiltration, transforming growth factor-beta production, and upregulation of transgelin in the human and mouse endometria, as well as the development of endometriotic lesions in a mouse model of endometriosis.
TRENDS IN MOLECULAR MEDICINE
(2023)
Review
Physiology
Chia-Bao Chu, Chao-Chun Yang, Shaw-Jenq Tsai
Summary: Hidradenitis suppurativa is a chronic inflammatory skin disease that commonly affects areas like the axillae and groins, triggered by factors like smoking and obesity. It is more prevalent in women in Western countries but has a reversed male-to-female ratio in oriental countries, and is also influenced by sex hormones.
CHINESE JOURNAL OF PHYSIOLOGY
(2021)
Article
Dermatology
Chia-Bao Chu, Wan-Lin Li, Sheng-Hsiang Lin, Chao-Kai Hsu, Chao-Chun Yang, Shaw-Jenq Tsai
Summary: The study revealed that smoking is correlated with the severity of HS, and smoking status and gender can influence the clinical characteristics of HS.
DERMATOLOGICA SINICA
(2021)