Article
Oncology
Zirong Huo, Xiaoguang Li, Jieyu Zhou, Yuqin Fan, Zhentao Wang, Zhihua Zhang
Summary: DNA methylation and miRNA-target genes are important in tumor development, and PLAU was found to be overexpressed in HNSCC, serving as an independent diagnostic and prognostic biomarker. The study also suggested that hypomethylation and downregulation of miR-23b-3p may contribute to the oncogenic role of PLAU in HNSCC.
CANCER CELL INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Alvaro Gutierrez, Hannah Demond, Priscilla Brebi, Carmen Gloria Ili
Summary: Colorectal cancer is the third most common cancer globally, and biomarkers play a crucial role in diagnosis and predicting metastasis. Key signaling pathways associated with cancer progression include the MAPK pathway, p53 pathway, and TGF-beta pathway.
Review
Oncology
Farah J. Nassar, Zahraa S. Msheik, Rihab R. Nasr, Sally N. Temraz
Summary: Colorectal cancer is a deadly disease with a high mortality rate worldwide; early detection is crucial for improving survival outcomes; traditional CRC diagnostic tests have limitations, and methylated circulating tumor DNA shows promise as a potential biomarker worth further investigation.
CLINICAL EPIGENETICS
(2021)
Article
Biochemistry & Molecular Biology
Yi Chen, Haizhou Liu, Shufang Ning, Changhong Wei, Jilin Li, Wene Wei, Litu Zhang
Summary: This study aims to explore the diagnostic and prognostic value of plasma miRNA in colorectal cancer (CRC) patients and establish a prognostic model. The results showed that miR-96/miR-99b can be used as a promising biomarker for early detection of metastatic CRC (mCRC) patients, and the nomogram based on 5 characteristics has satisfactory prognostic value.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Medicine, Research & Experimental
Zijian Chen, Zenghong Huang, Yanxin Luo, Qi Zou, Liangliang Bai, Guannan Tang, Xiaolin Wang, Guangwen Cao, Meijin Huang, Jun Xiang, Huichuan Yu
Summary: This study found that the NTRK3 gene promoter was more frequently methylated in CRC, leading to suppressed gene expression. It was confirmed that NTRK3 promoter methylation was associated with survival outcome in CRC and a nomogram predicting survival outcome was developed. Moreover, NTRK3 promoter methylation also predicted survival outcomes in other tumors.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Yonghuan Mao, Ji Miao, Ling Xi, Hanwen Tong, Xiaofei Shen, Qiang Li, Chunzhao Yu
Summary: Colorectal cancer (CRC) is a common and deadly cancer worldwide. This study investigated the role of circRNAs in CRC and identified circSKA3 as the most significantly upregulated circRNA in CRC tissues. Further experiments showed that circSKA3 promotes the proliferation, migration, and invasion of CRC cells. The study also revealed that circSKA3 interacts with miR-1238 and YTHDF2, leading to decreased methylation of STAT5A. These findings suggest that circSKA3 could be a novel target for CRC treatment.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Oncology
Jing Hu, Deyu Liao, Zijiu Sun, Wei Ren, Ling Zhao, Yuting Fang, Kai Hu, Huomei Yu, Shiyan Liu, Lan Zhou, Tongchuan He, Yan Zhang
Summary: This study discovered that HPV16 E6 and E7 can affect the development of HPV16-positive cervical cancer by regulating the expression of miR-23b-3p and ICAT genes, which is significant for the treatment of HPV16-associated cervical cancer.
Article
Biochemistry & Molecular Biology
Hui Lin, Xian Xu, Kelie Chen, Zhiqin Fu, Shengchao Wang, Yaqing Chen, Honghe Zhang, Yuequn Niu, Hanwen Chen, Hongfei Yu, Jian-zhong Shao, Weiguo Lu, Yihua Wu, Dajing Xia
Summary: This paper explores the functional role and molecular mechanism of long noncoding RNA CASC15 in ovarian cancer. In vitro and in vivo experiments validate CASC15 as an oncogenic gene that enhances metastasis in ovarian cancer. It is shown that miR-23b-3p and miR-24-3p directly target CASC15 and CASC15 regulates SMAD3 expression through these microRNAs.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Masoud Asefi, Massoud Saidijam, Nayebali Rezvani, Ali Reza Soltanian, Ali Reza Khalilian, Ali Mahdavinezhad
Summary: This study found that there were higher levels of methylated miR-138-5p and PDL1 protein in colorectal cancer patients, which could serve as diagnostic biomarkers for early detection of this cancer.
PERSONALIZED MEDICINE
(2022)
Review
Oncology
Yu-Xin Guo, Na Wang, Wen-Cheng Wu, Cui-Qin Li, Rui-Heng Chen, Yuan Zhang, Xing Li
Summary: Short-stranded miRNAs, like miR-23b, play a crucial role in regulating gene expression and are involved in various cellular processes such as cell proliferation, differentiation, and apoptosis. The specific alterations in miR-23b expression patterns are potential biomarkers for early disease diagnosis and therapeutic intervention in cancer and autoimmune diseases. MiR-23b exhibits multifunctional roles in modulating tumor cell proliferation and apoptosis, as well as in inflammatory cell activation, differentiation, and migration.
JOURNAL OF ONCOLOGY
(2021)
Article
Genetics & Heredity
Lin Han, Yanjun Sun, Cansheng Lu, Chungeng Ma, Jian Shi, Dengqun Sun
Summary: MiR-3614-5p is associated with colorectal cancer, with low expression predicting poor survival rate and correlating with N, M, pathologic stage, neoplasm type, and lymphatic invasion. High expression enriches the P53 pathway and enhances NK T cell activation.
FRONTIERS IN GENETICS
(2021)
Article
Medicine, General & Internal
Luyao Zhao, Muran Li, Shiwu Zhang, Yandi Liu
Summary: This study evaluated the potential performance of plasma SEPT9 methylation as a noninvasive biomarker for the diagnosis of gastric cancer. The results suggest that mSEPT9 may serve as a useful and noninvasive biomarker for the diagnosis of gastric cancer.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Rashidah Baharudin, Nurul Qistina Rus Bakarurraini, Imilia Ismail, Learn-Han Lee, Nurul Syakima Ab Mutalib
Summary: Colorectal cancer is a major cause of cancer-related deaths worldwide, and microRNAs play a significant role in its occurrence and progression. However, the methylation profiles of microRNAs in colorectal cancer patients are still unknown. Methylation is an important factor in cancer detection, and this review aims to provide insight into the current understanding of microRNA methylation in colorectal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Mengsha Zou, Jinze Shen, Yuchen Wu, Chenming Zhong, Li Fang, Feng Zhu, Shiwei Duan
Summary: This article analyzes the deficiencies and challenges of miR-411 research and discusses its potential in cancer. MiR-411 is abnormally expressed in various cancers and participates in the regulation of multiple signaling pathways. The expression of miR-411 is related to the diagnosis, prognosis, and drug sensitivity in cancer patients.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Dong Dong, Runshi Zhang, Jie Shao, Aimin Zhang, Yichao Wang, Yunli Zhou, Yueguo Li
Summary: Hypermethylation of UNC5C and UNC5D genes is associated with repression in colorectal cancer, and has potential diagnostic and prognostic value. UNC5A and UNC5B show no significant methylation changes in CRC. High methylation levels of UNC5C and UNC5D are independently predictive of poor progression-free and overall survival in CRC.
CLINICAL EPIGENETICS
(2021)