Article
Biology
Hueng-Chuen Fan, Fung-Wei Chang, Jeng-Dau Tsai, Kao-Min Lin, Chuan-Mu Chen, Shinn-Zong Lin, Ching-Ann Liu, Horng-Jyh Harn
Summary: Telomeres cap the ends of eukaryotic chromosomes and are essential for genome protection and replication. The maintenance of telomere length is regulated by various factors and dysfunctions in telomere maintenance and telomerase activation are associated with diseases, particularly cancer. Understanding the molecular mechanisms behind telomere length regulation and protection is crucial for future therapeutic opportunities.
Article
Biotechnology & Applied Microbiology
Zhiwen Liu, Li Zhang, Wen Chen, Fenqian Yuan, Zhi Yang, Sheng Liu, Fei Le
Summary: In this study, it was found that miR-195-5p regulates cell proliferation, apoptosis, and invasion in human thyroid cancer by interacting with TERT. Overexpression of miR-195-5p inhibits proliferation and invasion, and promotes apoptosis, effects that can be reversed by the overexpression of TERT. This suggests that miR-195-5p may serve as a potential therapeutic target for human thyroid cancer.
Article
Oncology
Olivier Adotevi, Dewi Vernerey, Pascale Jacoulet, Aurelia Meurisse, Caroline Laheurte, Hamadi Almotlak, Marion Jacquin, Vincent Kaulek, Laura Boullerot, Marine Malfroy, Emeline Orillard, Guillaume Eberst, Aurelie Lagrange, Laure Favier, Marie Gainet-Brun, Ludovic Doucet, Luis Teixeira, Zineb Ghrieb, Anne-Laure Clairet, Yves Guillaume, Marie Kroemer, Didier Hocquet, Melanie Moltenis, Samuel Limat, Elisabeth Quoix, Celine Mascaux, Didier Debieuvre, Christine Fagnoni-Legat, Christophe Borg, Virginie Westeel
Summary: The purpose of this study was to test the safety, immunogenicity, and efficacy of UCPVax vaccine in patients with metastatic non-small-cell lung cancer. The results showed that UCPVax vaccine was highly immunogenic and safe, and achieved interesting 1-year survival rate in advanced NSCLC patients.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Qingrong Li, Qiang Ma, Lei Xu, Chuanli Gao, Lihua Yao, Jilin Wen, Miyuan Yang, Jibing Cheng, Xi Zhou, Jiang Zou, Xiaowu Zhong, Xiaolan Guo
Summary: hTERT is significantly upregulated in esophageal squamous cancer, promoting proliferation and migration of cancer cells. DHA inhibits proliferation and migration of esophageal cancer cells by down-regulating hTERT expression through the ROS/SP1 pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Marta Mellai, Omar Porrini Prandini, Aurora Mustaccia, Valentina Fogazzi, Marta Allesina, Marco Krengli, Renzo Boldorini
Summary: pTERT mutations were significantly associated with histologic grade and prognosis in malignant meningiomas, supporting their use in prognostic classification. The mutation rate was higher in anaplastic meningiomas compared to atypical tumors, indicating their potential as adverse prognostic factors.
Article
Biochemistry & Molecular Biology
Li Tao, Wei Zhang, Yaxin Zhang, Mei Zhang, Yueying Zhang, Xing Niu, Qing Zhao, Zhenxing Liu, Yuyin Li, Aipo Diao
Summary: The study showed that caffeine can promote the expression of TERT to extend telomere length and prevent cellular senescence. In animal studies, caffeine also reversed the decline in organ index and improved tissue structure in aging mice. These results suggest that caffeine-containing foods can delay cellular senescence and aging through the expression of TERT.
Article
Biochemistry & Molecular Biology
Jeff Sherman, Grant Verstandig, Yisroel Brumer
Summary: Advancements in biotechnology and machine learning have created a conducive environment for exploring relationships between genomic and epigenetic data with potential therapeutic implications. The study found that CRISPR knockout has strong efficacy in inhibiting growth of tumor cells with varying levels of TERT expression, providing key biomarkers for therapeutic efficacy and potential pathways for drug development. These findings further support the potential of artificial intelligence in oncology.
Article
Medicine, General & Internal
Jie Xu, Fang-Ping Xu, Zhi-Hua Liu, Qian Cui, Ke-Ping Zhang, Zhi Li
Summary: This study investigated the correlations between mutations in the TERT promoter and IDH1/2 mutations or 1p/19q deletion in human gliomas. The results showed a positive correlation between TERT promoter mutations and 1p/19q deletion, as well as a negative correlation between TERT promoter mutations and IDH gene mutations, except in certain cases. This suggests a complex inter-regulatory relationship between these mutations in human gliomas.
Article
Obstetrics & Gynecology
Shuang Sun, Yuhong Wang, Ying Liu, Zongxiang Leng, Yujuan Jiang, Yu Liang, Zhe Jiang
Summary: This study investigates the relationship between hTERT gene polymorphisms and susceptibility to cervical cancer in women infected with high-risk HPV. The results show that certain genotypes of the hTERT gene are associated with increased susceptibility to high-risk HPV infection and certain clinicopathological parameters in cervical cancer patients.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2023)
Review
Cell Biology
Rhafaela Lima Causin, Ana Julia Aguiar de Freitas, Cassio Murilo Trovo Hidalgo Filho, Ricardo dos Reis, Rui Manuel Reis, Marcia Maria Chiquitelli Marques
Summary: Through a systematic review of cervical cancer microRNA studies, 26 differentially expressed microRNAs were identified in different stages of cervical cancer development. Findings suggest that some dysregulated microRNAs are associated with specific stages of cervical cancer progression, playing important roles in key cancer hallmarks. These findings also suggest potential for using stage-specific microRNAs as biomarkers for cancer classification and monitoring cervical cancer progression.
Review
Health Care Sciences & Services
Irena Velkova, Martina Pasino, Zumama Khalid, Paola Menichini, Emanuele Martorana, Alberto Izzotti, Alessandra Pulliero
Summary: Ferroptosis is a cell death pathway triggered by an imbalance between oxidant and antioxidant production, which plays an emerging role in tumorigenesis. It is regulated at three levels: iron metabolism, the antioxidant response, and lipid metabolism. Epigenetic dysregulation, involving microRNA mutations, is a hallmark of human cancer, and microRNAs have been found to modulate cancer growth and development through the ferroptosis pathway. This review summarizes the mechanism of ferroptosis initiation, the potential role of microRNAs in controlling this process, and the impact of treatments on ferroptosis in cancer.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Anna A. Plyasova, Dmitry D. Zhdanov
Summary: Alternative splicing of hTERT pre-mRNA regulates telomerase activity and determines cell functions. In addition to telomerase activity regulation, alternative splicing provides cells with splice variants that may have alternative biological activities.
Review
Biochemistry & Molecular Biology
Tsung-Jang Yeh, Chi-Wen Luo, Jeng-Shiun Du, Chien-Tzu Huang, Min-Hung Wang, Tzer-Ming Chuang, Yuh-Ching Gau, Shih-Feng Cho, Yi-Chang Liu, Hui-Hua Hsiao, Li-Tzong Chen, Mei-Ren Pan, Hui-Ching Wang, Sin-Hua Moi
Summary: Head and neck cancers (HNCs) are a major global malignancy. Telomerase reactivation through TERT promoter mutations has been linked to carcinogenesis. These mutations have high frequencies in HNCs and are associated with poor survival. Therapies targeting telomerase have been developed, but few have reached clinical trials. This review summarizes the current understanding and evidence of TERT promoter mutations in HNC patients.
Article
Oncology
Ji Hye Moon, Ilias P. Nikas, Kyung Chul Moon, Bohyun Kim, Han Suk Ryu
Summary: This study demonstrates that hTERT immunocytochemistry (ICC) can be used as an ancillary test in routine cytology practice to improve the sensitivity and specificity of urine cytology for urothelial carcinoma diagnosis and surveillance.
Article
Biochemistry & Molecular Biology
Shuang Li, Qian Xin, Guangyao Fang, Yi Deng, Fengyuan Yang, Chenming Qiu, Yongjian Yang, Cong Lan
Summary: Physical exercise can prevent cardiac hypertrophy by upregulating mitochondrial TERT expression. Overexpression of mitochondrial-targeted TERT improves mitochondrial dysfunction and reduces oxidative stress, leading to the attenuation of cardiac hypertrophy.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)