Article
Medicine, Research & Experimental
Longfei Yang, Lili Zhong, Zhiming Ma, Yujie Sui, Jia'nan Xie, Xin Liu, Tonghui Ma
Summary: Alantolactone has shown antifungal activities against Candida albicans and can reduce its adhesion and biofilm formation. Therefore, it may be a promising candidate for developing antifungal drugs.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Horticulture
Chen Li, Jiaqi Tao, Zhaoxia Wu
Summary: Mechanical damage during processing can accelerate the senescence and deterioration of fresh-cut red pitaya. In this study, a low-concentration and long-term gaseous ozone treatment was found to delay the decline in fruit quality, enhance the antioxidant activities, and regulate reactive oxygen species (ROS) metabolism of fresh-cut red pitaya fruit. The ozone treatment improved the activity of antioxidant enzymes, maintained the redox balance, and delayed senescence.
SCIENTIA HORTICULTURAE
(2023)
Article
Chemistry, Multidisciplinary
Yu-Ting Jiao, Yi-Ran Kang, Ming-Yong Wen, Hui-Qian Wu, Xin-Wei Zhang, Wei-Hua Huang
Summary: In this study, a dual-wire nanosensor was developed to measure intracellular GSH and ROS levels with high temporal resolution. The results revealed the rapid initiation and short-lived elimination process of the GSH system against ROS burst, with residual ROS still present in the cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Sihan Jia, Sunkui Ke, Li Tu, Shengqiang Chen, Bingkun Luo, Yeqi Xiong, Yang Li, Peiyuan Wang, Shefang Ye
Summary: In this study, a tumor microenvironment (TME)-responsive Cu-based metal-mesoporous organosilica nanoplatform incorporating vitamin k3 (VK3) was developed for enhanced chemodynamic therapy (CDT) of cancer. The nanoplatform could deplete glutathione (GSH) and specifically regenerate hydrogen peroxide (H2O2), resulting in synergistic CDT against tumors. Both in vitro and in vivo studies demonstrated the excellent biosafety and highly efficient tumor therapy potential of the CuO@MON-PEG/VK3 nanoplatform with multiple oxidative stress amplification.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Zhanhong Han, Zhenyu Wang, Yang Bi, Yuanyuan Zong, Di Gong, Bin Wang, Baojun Li, Edward Sionov, Dov Prusky
Summary: The research findings show that the pH modulation by Trichothecium roseum affects the colonization ability of the fungus and the host response, including the production and scavenging of reactive oxygen species in apple fruits. Inoculation at pH 3 results in lower cell membrane permeability and oxidative stress, while enhancing the activity of antioxidant enzymes in the fruit tissue.
Article
Environmental Sciences
Debabrata Dolui, Indraneel Saha, Malay Kumar Adak
Summary: The study showed that pre-treatment with GSH could significantly reduce oxidative stress response in Salvinia natans L. under 2,4-D, as well as other stress conditions. Additionally, changes in enzyme activity may serve as biomarkers for oxidative stress in plants.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Nanoscience & Nanotechnology
Xidong Tian, Hriday Bera, Xiong Guo, Ruizhao Xu, Jin Sun, Zhonggui He, Dongmei Cun, Mingshi Yang
Summary: This study introduced redox-responsive PTX dimeric nanoparticles for pulmonary delivery to achieve effective therapeutic outcomes against metastatic lung cancer with reduced systemic and local toxicities. These nanoparticles exhibited optimal drug release behavior, excellent colloidal stability, cellular uptake efficiency, and discriminating cytotoxicity between cancer and healthy cells. In a mouse model of metastatic lung cancer, intratracheally delivered PTX dimeric nanoparticles showed stronger anticancer potential with reduced systemic toxicity compared to traditional Taxol intravenous injection.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Plant Sciences
Sabina Ackah, Yang Bi, Sulin Xue, Salimata Yakubu, Ye Han, Yuanyuan Zong, Richard Atinpoore Atuna, Dov Prusky
Summary: This study investigated the effects of post-harvest chitosan treatment on ROS production, cell membrane integrity, and antioxidant systems in wounded apples during storage. The results showed that chitosan treatment stimulated antioxidant enzyme activities and reduced lipid peroxidation and membrane permeability in the wounded fruits. Additionally, chitosan increased the activities and substrates of the ascorbate-glutathione cycle-related enzymes. These findings suggest that chitosan can scavenge ROS and maintain fruit membrane integrity, making it a favorable preservative for inducing stress tolerance and preserving fruit quality.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
yingBai Ying, meiCheng Yue, Wenhua Wang, Lijuan Yang, Yongxiu Yang
Summary: This study demonstrates that Alloimperatorin induces autophagy in cervical cancer cells through the reactive oxygen species pathway, inhibiting cell proliferation and increasing apoptosis rate. In vivo experiments on nude mice show that Alloimperatorin effectively inhibits tumor growth, suggesting it as a potential new drug for cervical cancer treatment.
Article
Pharmacology & Pharmacy
Saurabh Kumar, Pooja Rani Mina, Ravi Kumar, Anirban Pal, Ateeque Ahmad, Sudeep Tandon, Mahendra P. Darokar
Summary: 4-Chlorothymol demonstrates potential antiplasmodial activity by increasing ROS and RNS levels, modulating enzyme activity, showing synergy with chloroquine, significantly suppressing parasitemia in vivo, and being safe for further exploration of therapeutic properties.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Lingyu Pan, Chunxia Gong, Yehong Sun, Yeke Jiang, Xianchun Duan, Yanquan Han, Yongzhong Wang
Summary: Ferroptosis is a newly discovered form of non-apoptotic cell death driven by iron-dependent lipid peroxidation. It significantly differs from other forms of cell death and is associated with various lung diseases. The regulation of ferroptosis involves changes in genes related to iron homeostasis and lipid peroxidation metabolism. The mechanism of ferroptosis is complex and involves activation of glutathione peroxidase 4, synthesis of glutathione, accumulation of reactive oxygen species, and the influence of ferrous ions and p53 proteins. The association between ferroptosis and lung disease deserves further study.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jan Capek, Tomas Rousar
Summary: The potential of nanomaterials in medicine and industry is vast, but their toxicity and impact on cellular pathways need to be thoroughly evaluated. Nanomaterials can induce the production of harmful reactive oxygen species in cells, while cells have various repair and antioxidant mechanisms to counteract this effect.
Article
Plant Sciences
Xiao-Han Tang, Xin Li, Yan Zhou, Yu-Ting He, Zhi-Ying Wang, Xue Yang, Wei Wang, Kun Guo, Wei Zhang, Yue Sun, Hong-Qing Li, Xiao-Fang Li
Summary: This study reveals that GAAP1 and GAAP4 play redundant positive roles in regulating ER stress response in plants. They maintain proteostasis by inhibiting ROS accumulation through regulating glutathione content, thus enhancing cell viability and survival.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Chemistry, Multidisciplinary
Ying Huang, Si Wu, Lu Zhang, Qingqing Deng, Jinsong Ren, Xiaogang Qu
Summary: In this study, a multistage chemodynamic therapy (CDT) specific to tumor cells is proposed, which can efficiently deplete the high glutathione (GSH) content in tumor cells. By consuming reserved GSH and inhibiting GSH synthesis in cancer cells, the CDT achieves potent GSH exhaustion. The glycolysis inhibitor used in this study not only increases the sensitivity of tumor cells to CDT, but also stimulates a protective mode in normal cells. This tumor-specific CDT utilizes the responsiveness of the glycolysis inhibitor and nanocarrier to the tumor microenvironment.
Article
Chemistry, Physical
Wenying Yu, Xiaolei Zhang, Yan Wang, Qiaoyun Zhang, Tong Chen, Yihe Zhang, Na Tian, Hongling Ou, Hongwei Huang
Summary: Semiconductor photocatalysis faces limitations in terms of location and time. BiOBrxI1-x solid solutions with oxygen vacancies (OVs) prepared by direct precipitation exhibit efficient catalytic performance for degrading tetracycline hydrochloride and killing Escherichia coli in the dark. BiOBr0.93I0.07 prepared in ethylene glycol shows the most prominent catalytic activity, and the catalysts can be regenerated in-situ by UV light after prolonged use.
APPLIED SURFACE SCIENCE
(2021)