Article
Multidisciplinary Sciences
Bumduuren Tuvshintulga, Arifin Budiman Nugraha, Tomoka Mizutani, Mingming Liu, Takahiro Ishizaki, Thillaiampalam Sivakumar, Xuenan Xuan, Naoaki Yokoyama, Ikuo Igarashi
Summary: This study reports the development of a stable transgenic Theileria equi line expressing enhanced green fluorescent protein/blasticidin S deaminase, with the integration of an expression cassette into the parasite's genome. The dynamics of parasitaemia between the transgenic and parental T. equi lines were comparable in vitro, providing new opportunities for better understanding of T. equi biology.
SCIENTIFIC REPORTS
(2021)
Article
Virology
Kati Tormanen, Shaohui Wang, Harry H. Matundan, Jack Yu, Ujjaldeep Jaggi, Homayon Ghiasi
Summary: The latency-associated transcript (LAT) of herpes simplex virus 1 (HSV-1) plays a significant role in the establishment of latency and reactivation. This study reveals that LAT contains two small noncoding RNAs (sncRNAs) that control the expression of the herpesvirus entry mediator (HVEM) by activating its promoter. These findings provide insights into the pathogenesis and regulation of latency in HSV-1.
JOURNAL OF VIROLOGY
(2022)
Article
Chemistry, Multidisciplinary
D. Chakraborty, D. Musib, R. Saha, A. Das, M. K. Raza, V Ramu, S. Chongdar, K. Sarkar, A. Bhaumik
Summary: This research demonstrates the synthesis of a stable phosphonate ligand-based fluorescent copper-MOF with excellent photocytotoxic effect against lung cancer cells and antibacterial efficacy against both Gram-positive and Gram-negative microorganisms. This MOF also shows good fluorescence properties for cancer cell imaging.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Chemistry, Physical
Meiwen Cao, Zijin Zhang, Xiaoyang Zhang, Yu Wang, Jingjing Wu, Zhihong Liu, Li Sun, Dong Wang, Tongtao Yue, Yuchun Han, Yingxiong Wang, Yilin Wang, Ming Wang
Summary: Smart artificial viruses have been developed through co-assembly of peptides and DNA, achieving stimuli-responsiveness and efficient gene transfection in cancer cells. These viruses protect DNA from digestion and release genes efficiently through enzyme-triggered structure disassembly. They resemble natural viruses in terms of structure and function, making them promising gene vectors.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Ying-Hao Pan, Xiao-Xiao Chen, Lei Dong, Na Shao, Li-Ya Niu, Qing-Zheng Yang
Summary: This study developed a fluorescent probe for monitoring the influence of NO on HIF-1 activity under hypoxia in hepatoma cells, with high selectivity and sensitivity. Live cell imaging experiments demonstrated the probe’s ability to image exogenous and endogenous NO in LDs, and revealed a correlation between HIF-1 induced LD level and NO level in hypoxic cells.
CHINESE CHEMICAL LETTERS
(2021)
Article
Pharmacology & Pharmacy
Zeting Yuan, Chaolian Liu, Yuji Sun, Yue Li, Honglei Wu, Shuli Ma, Jing Shang, Yueping Zhan, Peihao Yin, Feng Gao
Summary: This study designed iRGD-modified nanoparticles to co-deliver mTHPC and BU, aiming to enhance the efficacy of photodynamic therapy (PDT) in colorectal cancer (CRC). The nanoparticles passively accumulated in tumor cells, with mTHPC inducing apoptosis and death under laser irradiation, while the sustained release of BU inhibited hypoxia and angiogenesis by targeting the SRC-3/HIF-1α pathway.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Virology
Corentin Mallet, Jade Cochard, Sebastien Leclercq, Laetitia Trapp-Fragnet, Philippe Chouteau, Caroline Denesvre
Summary: The latent-to-lytic switch of herpesviruses is important for pathology recurrences and viral shedding. This study demonstrates that acute hypoxia can induce reactivation of Marek's disease virus and explores the molecular basis of this process.
JOURNAL OF VIROLOGY
(2022)
Article
Medicine, General & Internal
Wojciech Polom, Marcin Migaczewski, Jaroslaw Skokowski, Maciej Swierblewski, Tomasz Cwalinski, Leszek Kalinowski, Michal Pedziwiatr, Marcin Matuszewski, Karol Polom
Summary: This study demonstrates the potential of using two different fluorophores in colorectal surgery. Visualisation with fluorophores aids in intraoperative localization and angiography, optimizing surgical outcomes. The use of two separate dyes may represent a direction for the development of image-guided surgery, showcasing advancements in optical technologies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Can Lu, Xiaopeng Zhang, Josefine Schardey, Ulrich Wirth, Kathrin Heinrich, Luca Massiminio, Giulia Martina Cavestro, Jens Neumann, Alexandr Bazhin, Jens Werner, Florian Kuehn
Summary: The incidence of early-onset colorectal cancer (EO-CRC) is increasing globally, but the specific gene signatures in EO-CRC patients are largely unknown. In this study, the tumor microenvironment and gene expression profiles of EO-CRC patients with microsatellite stable (MSS-EO-CRC) were comprehensively characterized. MSS-EO-CRC showed similar patterns to late-onset colorectal cancer (MSS-LO-CRC) in terms of tumor-infiltrating immune cells, immunotherapeutic responses, molecular subtypes, and prognosis. Unique gene signatures and a risk score associated with PD-L1 expression were identified in MSS-EO-CRC, which could help improve treatment strategies for this patient population.
NPJ PRECISION ONCOLOGY
(2023)
Article
Pathology
Jung-Soo Pyo, Kyueng-Whan Min, Il Hwan Oh, Dae Hyun Lim, Byoung Kwan Son
Summary: The aim of this study was to evaluate the clinicopathological significance and associated signaling pathways of p21-activated kinase 1 (PAK1) in colorectal cancer (CRC). The results showed that PAK1 expression was significantly correlated with metastatic lymph node ratio and low immunoscore, as well as high expression of HIF-1 alpha and pFOXO1 in CRC. PAK1 expression was also associated with worse prognosis in CRC patients.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Pharmacology & Pharmacy
Aranka Brockmueller, Sosmitha Girisa, Mahzad Motallebi, Ajaikumar B. Kunnumakkara, Mehdi Shakibaei
Summary: A study found that Calebin A (CA), a compound derived from turmeric, inhibits colorectal cancer (CRC) cell migration by modulating the NF-kappa B pathway through the inhibition of HIF-1 alpha. CA suppressed the proliferation and migration of CRC cells, reduced the expression of metastatic factors, and induced apoptosis through inhibition of HIF-1 alpha. This research has important implications for cancer therapy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Physical
Takeru Nakamura, Hisahiro Sasabe, Shoki Abe, Kengo Kumada, Ryo Sugiyama, Takanori Hanayama, Junji Kido
Summary: In this study, a high-efficiency, long-lifetime, and high color purity green OLED was successfully developed using a BODIPY derivative. Through sophisticated device engineering and reducing carrier accumulation, the optimized device achieved a narrow full width at half maximum of 32 nm, CIE coordinates of (0.28, 0.67), approximately 19% external quantum efficiency, and a lifetime of 14 000 hours. The device stability was 4.7 times longer than previous works and among the best reported in the literature.
MOLECULAR SYSTEMS DESIGN & ENGINEERING
(2023)
Article
Biophysics
Hyeran Kim, Seul Gee Hwang, Kyeonghye Guk, Yoonji Bae, Hwangseo Park, Eun-Kyung Lim, Taejoon Kang, Juyeon Jung
Summary: RSV infections can cause severe diseases, and the emergence of drug-resistant RSV strains is concerning. We studied an antibody that can specifically detect palivizumab-resistant RSV strains and developed a rapid detection method for the S275F RSV antigen.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Oncology
Chao Liu, Ruiqi Liu, Bojun Wang, Jie Lian, Yang Yao, Haoxiu Sun, Chunhui Zhang, Lin Fang, Xin Guan, Jiaqi Shi, Shuling Han, Fei Zhan, Shengnan Luo, Yuanfei Yao, Tongsen Zheng, Yanqiao Zhang
Summary: IL-17A promotes resistance to anti-PD-1 therapy by increasing PD-L1 expression through the p65/NRF1/miR-15b-5p axis. Blocking IL-17A improves the efficacy of anti-PD-1 therapy in MSS CRC murine models, suggesting IL-17A as a potential therapeutic target to sensitize patients with MSS CRC to ICI therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Materials Science, Multidisciplinary
Shivangi Paliwal, Pradip Jana, Sneha Singh, Harishkumar Madhyastha, Thomas J. Webster, Abhimanyu Dev
Summary: In this study, a folic acid conjugated carbon dots nano delivery system was developed for targeted treatment of colorectal cancer. The system demonstrated pH-dependent drug release and showed high cellular uptake and apoptosis induction in colorectal cancer cells.
MATERIALS TODAY COMMUNICATIONS
(2022)