Article
Medicine, Research & Experimental
Enkhtuya Radnaa, Lauren Richardson, Brett Goldman, Jared K. Burks, Tuvshintugs Baljinnyam, Natasha Vora, Hui-Juan Zhang, Elizabeth A. Bonney, Arum Han, Ramkumar Menon
Summary: This study investigated the impact of oxidative stress on p38 MAPK signaling and cell fate, using amnion epithelial cells. The results showed that excessive activation of p38 can have adverse effects on cell behavior and tissue homeostasis.
Review
Biochemistry & Molecular Biology
Rahul Advani, Sara Luzzi, Emma Scott, Caroline Dalgliesh, Joachim Weischenfeldt, Jennifer Munkley, David J. Elliott
Summary: This article discusses the expression of splicing regulators ESRP1 and ESRP2 in aggressively proliferating primary prostate tumors as markers of disease progression. It suggests that ESRP1 and ESRP2 act as lineage survival oncogenes in prostate cancer and highlights the need to identify the gene expression targets controlled by these regulators to develop targeted therapies.
Article
Biochemistry & Molecular Biology
Shah Md. Toufiqur Rahman, Wenyuan Zhou, Alexander Deiters, Jason M. Haugh
Summary: Studying stress-activated signaling is challenging due to induced adaptation and imposed selection pressure. By using an optogenetic system to express light-activated p38 alpha or its upstream activator MKK6, the functional roles of these kinases in dynamic signaling programs are clarified.
Article
Emergency Medicine
Chao Liu, Zhao-Rui Sun, Meng-Meng Wang, Zhi-Zhou Yang, Wei Zhang, Yi Ren, Xiao-Qin Han, Rui Liu, Quan Li, Shi-Nan Nie
Summary: This study found that arctigenin has a protective effect on PQ-induced lung injury by attenuating cell apoptosis and suppressing ROS/p38 MAPK signaling. Arctigenin may be considered as a potential candidate drug for PQ-induced ALI.
WORLD JOURNAL OF EMERGENCY MEDICINE
(2022)
Review
Oncology
Samantha Gogola, Michael Rejzer, Hisham F. Bahmad, Wassim Abou-Kheir, Yumna Omarzai, Robert Poppiti
Summary: Prostate cancer is the second most common cancer in men worldwide, and treatment options include radiation therapy, surgery, and active surveillance. However, in most cases, the cancer eventually becomes castration-resistant. The transition from androgen-dependent to androgen-independent state is not well understood, but epithelial-to-non-epithelial transition plays a crucial role. This review summarizes the factors and pathways involved in this transition, as well as the diagnostic and prognostic biomarkers.
Article
Integrative & Complementary Medicine
Hu Xijiao, Cheng Yinglong, Kang Huanan, Li Shuoxi, Wang Yawen, Liu Jinzhe, Sun Yiming, Liu Li
Summary: This study investigated the effect of electroacupuncture on chronic fallopian tube inflammation in rats and its potential mechanisms. The results showed that electroacupuncture attenuated chronic salpingitis by down-regulating the TGF-01/MAPK signaling pathway.
JOURNAL OF TRADITIONAL CHINESE MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Nathalia Grave, Thamiris Becker Scheffel, Fernanda Fernandes Cruz, Liliana Rockenbach, Marcia Ines Goettert, Stefan Laufer, Fernanda Bueno Morrone
Summary: Gliomas are debilitating malignant brain tumors with limited response to therapies, driven by molecular abnormalities like mutations in regulatory networks. The MAPK pathway, particularly p38 MAPK activation, plays a crucial role in glioma cell invasion and metastasis, and is associated with tumor grade and chemotherapy resistance, underlining its potential as a therapeutic target.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Dan Liang, Shiyun Tang, Lu Liu, Maoyuan Zhao, Xiao Ma, Yanling Zhao, Caifei Shen, Qingsong Liu, Jianyuan Tang, Jinhao Zeng, Nianzhi Chen
Summary: This study demonstrated that Tan-I inhibits the progression of gastric precancerous lesions by reversing the epithelial-mesenchymal transition process and reducing inflammation through the p38/STAT3 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Seung Kak Shin, Sujin Ryu, Seungyoon Nam, Seung Yeon Ha, Oh Sang Kwon, Yun Soo Kim, Se-Hee Kim, Ju Hyun Kim
Summary: This study evaluated the correlations between clinicopathological characteristics and epithelial-mesenchymal transition (EMT) markers in hepatocellular carcinoma (HCC) patients who underwent surgical resection, and identified a key regulator in the EMT process. The down-expression of E-cadherin and overexpression of p21-activated kinases 1 (PAK1)/Snail in HCC tissues were significantly associated with macrovascular invasion, microvascular invasion, large tumor size, and advanced tumor stage. Patients with these EMT markers showed early recurrence and poor overall survival. In vitro studies showed that inhibition of Rac1 decreased the expression of EMT markers and suppressed the migration and invasion of HCC cells. Therefore, Rac1 may be a potential therapeutic target for inhibiting EMT process in HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Yu Fan, Tu-Run Song, Qiang Wei, Lu Yang, Tao Lin, Xiao-Bing Feng, Xian-Ding Wang, Zhong-Li Huang, Shi-Jian Feng
Summary: Estrogen plays a role in the development of benign prostatic hyperplasia (BPH) through promoting AQP5 expression and subsequent epithelial-mesenchymal transition (EMT) in prostate cells. This study found that BPH tissues had higher AQP5 expression and EMT levels compared to normal prostate tissues. Estrogen-stimulated cells had increased AQP5 expression, cell proliferation, and EMT, which could be partially reversed by AQP5 knockdown.
CHINESE MEDICAL JOURNAL
(2021)
Article
Oncology
Abdulrahman Alwhaibi, Varun Parvathagiri, Arti Verma, Sandeep Artham, Mir S. Adil, Payaningal R. Somanath
Summary: Akt1 suppression in advanced prostate cancer promotes metastasis, but our understanding of its specific regulatory mechanisms is incomplete. By analyzing the miRNA and mRNA profiles of PC3 and DU145 cells, we identified the role of miRNAs and associated genes in Akt1-mediated epithelial-to-mesenchymal transition (EMT) in prostate cancer. We found that miR-199a-5p and let-7a-5p are involved in regulating TGF beta-R1 expression, and their expression changes correlate with EMT gene expression and cell motility in PC3 and DU145 cells. These findings highlight the potential therapeutic and early screening benefits of targeting miR-199a-5p and let-7a-5p in metastatic prostate cancer.
Article
Engineering, Biomedical
Mugdha Pol, Hanyuan Gao, He Zhang, Olivia J. George, Joseph M. Fox, Xinqiao Jia
Summary: Synthetic matrices with dynamic presentation of cell guidance cues are engineered to mimic prostate cancer progression and metastasis. A tunable hyaluronic acid-based hydrogel platform is developed using bioorthogonal tetrazine ligation with strained alkenes. The platform allows the spontaneous formation of multicellular tumoroids and the development of cellular protrusions in response to cell adhesive peptide modification. The engineered tumor model can be utilized to identify potential molecular targets and test pharmacological inhibitors, accelerating the design of innovative strategies for cancer therapeutics.
Article
Biochemistry & Molecular Biology
Janae D. Sweeney, Marija Debeljak, Stacy Riel, Ana Cecilia Millena, James R. Eshleman, Channing J. Paller, Valerie Odero-Marah
Summary: The research showed that SOD2 expression did not correlate with tumor aggressiveness or SOD2 genotype in prostate cancer. However, the Ala-SOD2 allele may promote EMT, leading to increased cell migration. The antioxidant MSKE could inhibit EMT mediated by Ala-SOD2 SNP, indicating promising therapeutic potential for halting prostate cancer progression.
Article
Medicine, Research & Experimental
Yao Li, Quan Li, Dujian Li, Jie Gu, Duocheng Qian, Xiaojing Qin, Yu Chen
Summary: The study found that exosomal PSGR promoted migration, invasion, stemness, and epithelial-mesenchymal transitions of prostate cancer cells, and reshaped the mRNA profiles of the cells.
Article
Biochemistry & Molecular Biology
Hwi Gon Kim, Ye Seon Lim, Seonyeong Hwang, Hye-Yoon Kim, Yuseok Moon, Yong Jung Song, Yong-Jin Na, Sik Yoon
Summary: DEHP, a commonly used plasticizer, may be linked to the development of endometriosis by inducing cell proliferation, migration, inflammation, and stemness through the TGF-β/Smad signaling pathway, providing novel insights into the pathogenesis of endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)