期刊
EPIGENOMICS
卷 8, 期 11, 页码 1507-1517出版社
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2016-0074
关键词
abuse; African-Americans; child maltreatment; CpG island shore; DNA methylation; epigenetic epidemiology; glucocorticoid receptor; health disparities; NR3C1; violence
资金
- Harvard Catalyst | The Harvard Clinical and Translational Science Center (National Center for Research Resources) [UL1 TR001102]
- Harvard Catalyst | The Harvard Clinical and Translational Science Center (National Center for Advancing Translational Sciences, NIH) [UL1 TR001102]
- Harvard University
- John Templeton Foundation [48424]
- Black Women's Health Study [R01 CA 058420, UM1CA 164974]
Aim: To investigate childhood abuse victimization in relation to adult DNA methylation levels in a novel region of NR3C1, with emotional support as a possible modifier. Materials & methods: 295 participants from the Black Women's Health Study. Multivariable linear regression models were used to compute differences in mean percent methylation levels. Results: Women reporting childhood abuse victimization exhibited higher mean NR3C1 methylation levels than nonabused women, with a clear dose-response relationship. Childhood emotional support appeared to attenuate associations only among women with the highest levels of physical and sexual abuse. Conclusion: NR3C1 mean methylation was higher among women who reported childhood abuse. Further research is warranted to clarify whether or the extent to which childhood emotional support buffers the association.
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