期刊
EPIGENOMICS
卷 8, 期 3, 页码 401-414出版社
FUTURE MEDICINE LTD
DOI: 10.2217/epi.15.119
关键词
DNA methylation; DNA methyltransferase; histone modification; neurogenesis; TET family protein
资金
- NIH [NS079625, NS05160, MH102690]
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH102690] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS051630, R01NS079625] Funding Source: NIH RePORTER
Neurogenesis is not limited to the embryonic stage, but continually proceeds in the adult brain throughout life. Epigenetic mechanisms, including DNA methylation, histone modification and noncoding RNA, play important roles in neurogenesis. For decades, DNA methylation was thought to be a stable modification, except for demethylation in the early embryo. In recent years, DNA methylation has proved to be dynamic during development. In this review, we summarize the latest understanding about DNA methylation dynamics in neurogenesis, including the roles of different methylation forms (5-methylcytosine, 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine), as well as their 'writers', 'readers' and interactions with histone modifications.
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