期刊
EPIGENOMICS
卷 8, 期 11, 页码 1527-1537出版社
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2016-0088
关键词
Duchenne muscular dystrophy; GRMD dog; lncRNA; MDX mice; miRNA
资金
- Association Francais contre les Myo-pathies
- National Institute for Health Research Biomedical Research Centre at Great Ormond Street Hospital for Children NHS Foundation Trust and University College London
- Inter-university Attraction Poles Program-Belgian State-Belgian Science Policy [P7/30]
- Muscular Dystrophy UK
Noncoding RNAs (ncRNAs) such as miRNAs and long noncoding RNAs modulate gene transcription in response to environmental stressors and other stimuli. A role for ncRNAs in muscle pathologies has been demonstrated and further evidence suggests that ncRNAs also play a role in Duchenne muscular dystrophy (DMD). Studies investigating the differential expression of miRNAs in biological fluids between DMD patients and models of dystrophin deficiency (the MDX mouse model, canine models of DMD) and controls have been published, as these have a role in fibrosis. Long noncoding RNAs are differentially expressed in DMD patients and may, in part, have a mechanism of action via targeting of miRNAs. Although many of these recent findings need to be confirmed, ncRNAs may prove to be useful as potential biomarkers of disease. However, their use as therapeutic targets in DMD remains unclear.
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