Mitochondrial metabolic remodeling in response to genetic and environmental perturbations
出版年份 2016 全文链接
标题
Mitochondrial metabolic remodeling in response to genetic and environmental perturbations
作者
关键词
-
出版物
Wiley Interdisciplinary Reviews-Systems Biology and Medicine
Volume 8, Issue 4, Pages 272-285
出版商
Wiley
发表日期
2016-05-20
DOI
10.1002/wsbm.1334
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis
- (2015) Simone Cardaci et al. NATURE CELL BIOLOGY
- Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism
- (2015) Charlotte Lussey-Lepoutre et al. Nature Communications
- Fumarate induces redox-dependent senescence by modifying glutathione metabolism
- (2015) Liang Zheng et al. Nature Communications
- Mitochondrial dysfunction in cancer chemoresistance
- (2014) Nicoletta Guaragnella et al. BIOCHEMICAL PHARMACOLOGY
- IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism
- (2014) A. R. Grassian et al. CANCER RESEARCH
- The role of mitochondria in the oncogenic signal transduction
- (2014) Christian Frezza INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
- (2014) Edward T. Chouchani et al. NATURE
- Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases
- (2014) Hanna Tarhonskaya et al. Nature Communications
- Mutant IDH1 Enhances the Production of 2-Hydroxyglutarate Due to Its Kinetic Mechanism
- (2013) Alan R. Rendina et al. BIOCHEMISTRY
- Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML
- (2013) A. Chaturvedi et al. BLOOD
- SDH Mutations Establish a Hypermethylator Phenotype in Paraganglioma
- (2013) Eric Letouzé et al. CANCER CELL
- In Vivo HIF-Mediated Reductive Carboxylation Is Regulated by Citrate Levels and Sensitizes VHL-Deficient Cells to Glutamine Deprivation
- (2013) Paulo A. Gameiro et al. Cell Metabolism
- A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence
- (2013) Joanna Kaplon et al. NATURE
- (R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
- (2013) J.-A. Losman et al. SCIENCE
- Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells
- (2013) Sarah-Maria Fendt et al. Nature Communications
- A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia
- (2013) Julie Adam et al. Cell Reports
- Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency
- (2013) Nicola Ternette et al. Cell Reports
- Isocitrate dehydrogenase 2 mutation is a frequent event in osteosarcoma detected by a multi-specific monoclonal antibody MsMab-1
- (2013) Xing Liu et al. Cancer Medicine
- IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma
- (2012) R. A. Cairns et al. BLOOD
- Disruption of Wild-Type IDH1 Suppresses D-2-Hydroxyglutarate Production in IDH1-Mutated Gliomas
- (2012) G. Jin et al. CANCER RESEARCH
- Glucose Utilization via Glycogen Phosphorylase Sustains Proliferation and Prevents Premature Senescence in Cancer Cells
- (2012) Elena Favaro et al. Cell Metabolism
- Biphasic Papillary and Lobular Breast Carcinoma With PIK3CA and IDH1 Mutations
- (2012) Daphne Ang et al. DIAGNOSTIC MOLECULAR PATHOLOGY
- Inhibition of -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
- (2012) M. Xiao et al. GENES & DEVELOPMENT
- Mutation Analysis of Isocitrate Dehydrogenase in Acute Lymphoblastic Leukemia
- (2012) Yiqun Zhang et al. Genetic Testing and Molecular Biomarkers
- Mitochondrial dysfunction and cancer metastasis
- (2012) Emily I. Chen JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- The Potential for Isocitrate Dehydrogenase Mutations to Produce 2-Hydroxyglutarate Depends on Allele Specificity and Subcellular Compartmentalization
- (2012) Patrick S. Ward et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
- (2012) Peppi Koivunen et al. NATURE
- IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
- (2012) Sevin Turcan et al. NATURE
- IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics
- (2012) Masato Sasaki et al. NATURE
- Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells
- (2012) Fabian V. Filipp et al. Pigment Cell & Melanoma Research
- SDH mutations in cancer
- (2011) Chiara Bardella et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
- (2011) Wei Xu et al. CANCER CELL
- An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma
- (2011) Aikseng Ooi et al. CANCER CELL
- Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling
- (2011) Julie Adam et al. CANCER CELL
- The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
- (2011) Rasheduzzaman Chowdhury et al. EMBO REPORTS
- Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status
- (2011) Chiara Bardella et al. JOURNAL OF PATHOLOGY
- Reductive carboxylation supports growth in tumour cells with defective mitochondria
- (2011) Andrew R. Mullen et al. NATURE
- Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase
- (2011) Christian Frezza et al. NATURE
- Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
- (2011) Christian M. Metallo et al. NATURE
- Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping
- (2011) D. R. Borger et al. ONCOLOGIST
- Metabolic Profiling of Hypoxic Cells Revealed a Catabolic Signature Required for Cell Survival
- (2011) Christian Frezza et al. PLoS One
- Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of -ketoglutarate to citrate to support cell growth and viability
- (2011) D. R. Wise et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate
- (2010) Patrick S. Ward et al. CANCER CELL
- Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
- (2010) Maria E. Figueroa et al. CANCER CELL
- SDHA is a tumor suppressor gene causing paraganglioma
- (2010) Nelly Burnichon et al. HUMAN MOLECULAR GENETICS
- Segregation of non-p.R132H mutations inIDH1in distinct molecular subtypes of glioma
- (2010) Lonneke A.M. Gravendeel et al. HUMAN MUTATION
- Oxidative phosphorylation is impaired by prolonged hypoxia in breast and possibly in cervix carcinoma
- (2010) Sara Rodríguez-Enríquez et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Isocitrate dehydrogenase-1 mutations: a fundamentally new understanding of diffuse glioma?
- (2010) Nanne K Kloosterhof et al. LANCET ONCOLOGY
- Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations
- (2010) K. A. Janeway et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Selective acquisition of IDH1 R132C mutations in astrocytomas associated with Li-Fraumeni syndrome
- (2009) Takuya Watanabe et al. ACTA NEUROPATHOLOGICA
- Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas
- (2009) Christian Hartmann et al. ACTA NEUROPATHOLOGICA
- IDH1 Mutations Are Early Events in the Development of Astrocytomas and Oligodendrogliomas
- (2009) Takuya Watanabe et al. AMERICAN JOURNAL OF PATHOLOGY
- Mutant Metabolic Enzymes Are at the Origin of Gliomas
- (2009) H. Yan et al. CANCER RESEARCH
- Hypoxia-induced autophagy: cell death or cell survival?
- (2009) Nathalie M Mazure et al. CURRENT OPINION IN CELL BIOLOGY
- HIF-1: upstream and downstream of cancer metabolism
- (2009) Gregg L Semenza CURRENT OPINION IN GENETICS & DEVELOPMENT
- Loss or Silencing of the PHD1 Prolyl Hydroxylase Protects Livers of Mice Against Ischemia/Reperfusion Injury
- (2009) Martin Schneider et al. GASTROENTEROLOGY
- Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers
- (2009) Mi Ran Kang et al. INTERNATIONAL JOURNAL OF CANCER
- Isocitrate Dehydrogenase Mutations Are Rare in Pheochromocytomas and Paragangliomas
- (2009) José Gaal et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Succinate dehydrogenase subunit B (SDHB) gene deletion associated with a composite paraganglioma/neuroblastoma
- (2009) R Armstrong et al. JOURNAL OF MEDICAL GENETICS
- Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
- (2009) Lenny Dang et al. NATURE
- Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome
- (2009) Elaine R. Mardis et al. NEW ENGLAND JOURNAL OF MEDICINE
- IDH1andIDH2Mutations in Gliomas
- (2009) Hai Yan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Regulation of succinate-ubiquinone reductase and fumarate reductase activities in human complex II by phosphorylation of its flavoprotein subunit
- (2009) Eriko TOMITSUKA et al. PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
- SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma
- (2009) H.-X. Hao et al. SCIENCE
- Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1
- (2009) S. Zhao et al. SCIENCE
- How mitochondria produce reactive oxygen species
- (2008) Michael P. Murphy BIOCHEMICAL JOURNAL
- Germline SDHB Mutations and Familial Renal Cell Carcinoma
- (2008) C. Ricketts et al. JNCI-Journal of the National Cancer Institute
- Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism
- (2008) Julián Aragonés et al. NATURE GENETICS
- An Integrated Genomic Analysis of Human Glioblastoma Multiforme
- (2008) D. W. Parsons et al. SCIENCE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started