期刊
EXPERIMENTAL AND THERAPEUTIC MEDICINE
卷 11, 期 6, 页码 2477-2483出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/etm.2016.3218
关键词
Danggui Buxue Tang; renal function; glomerular ultrastructure; heparanase; diabetic nephropathy
资金
- National Natural Science Foundation of China [30973819]
Danggui Buxue Tang (DBT) is a simple combination of Radix Astragali and Radix Angelica sinensis (5:1), with a variety pharmacological activities. In the present study, a single intravenous injection of 30 mg/kg streptozotocin and subsequent six weeks of high glucose diet in Sprague Dawley rats were used to induce diabetic nephropathy. Rats with diabetes mellitus showed increased levels of fasting blood glucose (FBG), blood urea nitrogen (BUN), serum creatinine (Scr), serum and urine beta 2-microglobulins (beta 2-MG), and type IV collagen (all P<0.05). DBT treatment significantly decreased the levels of FBG, BUN, Scr, serum and urine beta 2-MG, and type IV collagen. Furthermore, DBT treatment significantly and dose-dependently restored the ultrastructural injury, and reduced the expression of heparanase, compared with the vehicle (P<0.05). Therefore, DBT may be a novel therapeutic approach for the prevention and treatment of diabetic nephrology.
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