Review
Biochemistry & Molecular Biology
Yi-Wen Duan, Shao-Xia Chen, Qiao-Yun Li, Ying Zang
Summary: This review focuses on the neuroimmune mechanism of neuropathic pain. TNF-alpha plays a crucial role in inducing and modulating neuropathic pain by facilitating peripheral and central sensitization. It controls cell survival and death through an inflammatory response and programmed cell death mechanisms. Overproduction of TNF-alpha in certain brain structures has an important role in pain-associated emotional disorders and memory deficits. The review also highlights the research prospects of the TNF-alpha-necroptosis pathway in pain modulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Yang Liu, Wei Yang, Jinqi Xue, Juntong Chen, Shiqing Liu, Shijie Zhang, Xiaohui Zhang, Xi Gu, Youjing Dong, Peng Qiu
Summary: The proportion of advanced age patients undergoing surgical procedures is increasing due to advancements in surgical and anesthesia technologies as well as an aging population. Postoperative cognitive dysfunction (POCD) is a common complication in older patients and its development involves multiple factors. Neuroinflammation is considered a leading hypothesis and plays a crucial role in the understanding and treatment of POCD.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biotechnology & Applied Microbiology
Qi Wang, Meina Ma, Hong Yu, Hongmei Yu, Shuai Zhang, Rui Li
Summary: The study demonstrates that mirtazapine has a protective effect on BV2 microglia against activation, neuroinflammation, and oxidative stress caused by isoflurane exposure. This effect may be mediated by the activation of TREM2. Therefore, mirtazapine could be a potential intervention strategy to prevent isoflurane exposure-induced cognitive dysfunction.
Article
Engineering, Biomedical
Qianyun Zhu, Yuting Huang, Xiaoling Zhu, Lijun Peng, Huan Wang, Shan Gao, Zhilai Yang, Jiqian Zhang, Xuesheng Liu
Summary: Postoperative cognitive dysfunction (POCD) is a significant problem that can lead to increased morbidity and mortality in patients. The excessive production of reactive oxygen species (ROS) and inflammation in the brain after surgery are major contributors to the development of POCD. In this study, mannose-coated superparamagnetic iron oxide nanoparticles (mSPIONs) were synthesized to effectively scavenge ROS and reduce inflammation, ultimately improving cognitive function in postoperative mice. These findings suggest that mSPIONs may be a promising strategy for preventing POCD.
MATERIALS TODAY BIO
(2023)
Article
Immunology
Klaske Oberman, Iris Hovens, Jacco de Haan, Joana Falcao-Salles, Barbara van Leeuwen, Regien Schoemaker
Summary: A single injection of ibuprofen before surgery improved short-term spatial memory and increased hippocampal neurogenesis in rats, although associated with increased microglia activity. Plasma cytokine levels were not significantly affected, but VEGF levels increased and IFABP levels decreased after ibuprofen treatment. The gut microbiome was not significantly impacted by surgery or ibuprofen, with effects in aged rats similar to those in young rats, although less pronounced.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Immunology
Mengxue Zhang, Yiqing Yin
Summary: Postoperative cognitive dysfunction (POCD) is a common clinical symptom after surgery, characterized by a decline in neurocognitive function. Neuroinflammation mediated by microglia is the key mechanism of POCD. Anesthetics are believed to be a major cause of POCD development, as they activate microglia and induce neuroinflammation. However, the role of anesthetics in POCD remains controversial. Anesthetics can have both anti-inflammatory and pro-inflammatory effects, suggesting their dual roles in the pathogenesis of POCD. This review discusses the mechanisms by which commonly used anesthetics regulate microglial activation through inflammatory signaling pathways, highlighting the anti-inflammatory properties of anesthetics and their potential to improve cognitive performance. The beneficial effects of anesthetics on POCD vary depending on dose, exposure time, and patients' characteristics, emphasizing the need for careful selection of anesthetics to minimize the incidence of POCD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Long Sun, Yue Yong, Pan Wei, Yongqiang Wang, He Li, Yalan Zhou, Wenqing Ruan, Xing Li, Jiangang Song
Summary: Electroacupuncture (EA) treatment significantly improves cognitive dysfunction in POCD mice by inhibiting neuroinflammation, protecting hippocampal neurons and tight junction proteins. Mechanistically, the effects of EA treatment depend on the inhibition of NLRP3 inflammasome and NF-kappa B pathway activation.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Immunology
Yile Zhou, Huihui Ju, Yan Hu, Tingting Li, Zhouyi Chen, Yuan Si, Xia Sun, Yi Shi, Hao Fang
Summary: This study aimed to investigate the involvement of regulatory T cells (Tregs) in the development of postoperative cognitive dysfunction (POCD). The findings from animal experiments demonstrated that POCD in aged mice was accompanied by elevated levels of inflammatory factors and increased circulating Tregs. Transfusion of Tregs from young mice partially restored the blood-brain barrier structure and alleviated POCD in aged mice, indicating a crucial role of aged Tregs in the occurrence of POCD.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Immunology
Liangyu Peng, Shuai Liu, Jiyan Xu, Wenjia Xie, Xin Fang, Tianjiao Xia, Xiaoping Gu
Summary: Research indicates that prolonged exposure to low-concentration anesthetics may induce neuroinflammation and cognitive decline, but pretreatment with metformin can alleviate these effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Genetics & Heredity
Hui Wang, Gang Ma, Jia Min, Jun Li, Weiran Shan, Zhiyi Zuo
Summary: Exposure to surgery with anesthesia early in life may lead to abnormal behavior, learning, and memory in humans. This study investigates the role of glial cell-derived neurotrophic factor (GDNF) and the inhibition of the ERK-CREB pathway in these effects. The results show that surgery and anesthesia decrease GDNF concentration, impair learning and memory, and increase proinflammatory cytokines. Intracerebroventricular injection of GDNF attenuates inflammation and inhibits ERK. Surgery also increases brain-derived natriuretic peptide (BNP) which impairs learning and memory through ERK inhibition and GDNF reduction.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Geriatrics & Gerontology
Yi Sun, Yuzhu Wang, Fan Ye, Victoria Cui, Dandan Lin, Hui Shi, Yan Zhang, Anshi Wu, Changwei Wei
Summary: This study evaluates the important neuroprotective role of SIRT1 in the pathogenesis of POCD. Enhancing SIRT1 function represents a promising therapeutic strategy for the prevention and treatment of POCD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Cell Biology
Giulia Guidotti, Chiara Scarlata, Liliana Brambilla, Daniela Rossi
Summary: The involvement of TNF alpha in ALS is controversial, with studies suggesting both protective and detrimental functions depending on the type of TNF alpha receptor activated. Understanding the impact of this cytokine on disease progression may lead to the development of effective therapies targeting the protective roles of TNF alpha and minimizing the detrimental effects.
Article
Immunology
Jun Liu, Tao Gao, Bin Zhou, Xiaoxiao Xu, Xiaojie Zhai, Qinghuan Yao, Xiaowei Chen, Lin Liu, Wei Cui, Xiang Wu
Summary: Postoperative cognitive dysfunction (POCD) refers to a decline in cognitive function in aged patients after surgery, with unclear pathological mechanisms. The overexpression of the P2X4 receptor in the central nervous system (CNS) has been associated with the onset of POCD. This study explored the potential of the food dye FGF to prevent POCD by down-regulating the CNS P2X4 receptor. The results showed that FGF significantly attenuated cognitive impairments, decreased P2X4 receptor expression, and inhibited neuroinflammation, suggesting that FGF may be a potential treatment for POCD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Neurosciences
Stephanie M. Muscat, Nicholas P. Deems, Michael J. Butler, Emmanuel A. Scaria, Menaz N. Bettes, Sean P. Cleary, Ross H. Bockbrader, Steven F. Maier, Ruth M. Barrientos
Summary: This study highlights the importance of addressing perioperative neurocognitive disorders (PNDs) and provides evidence that blocking toll-like receptor 4 (TLR4) activation can mitigate the cognitive impairment caused by morphine treatment. These findings offer a promising therapeutic target for preventing or treating PNDs.
JOURNAL OF NEUROSCIENCE
(2023)
Review
Geriatrics & Gerontology
Cong-mei Wang, Wei-can Chen, Yan Zhang, Shu Lin, He-fan He
Summary: Sevoflurane is widely used in anesthesia for surgical patients, but may increase the incidence of postoperative cognitive dysfunction (POCD). POCD affects patients' lives and adds burden to patients and their families. Understanding the mechanism of Sevoflurane-induced POCD is crucial for prevention and treatment.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Acoustics
Wei-Jian Wang, Jia-Hao Zhou, Guo-Liang He, Qiao-Lin Wu, Wei Gao, Jie-Hao Sun, Peng-Bo Zhang
JOURNAL OF ULTRASOUND IN MEDICINE
(2017)
Article
Biochemistry & Molecular Biology
Wei-jian Wang, Zi-li Meng, Yun-chang Mo, Jun-wei Liu, Cheng-chao Sun, Sheng-shou Hu, Hao Zhang
MOLECULAR BIOLOGY REPORTS
(2012)
Article
Peripheral Vascular Disease
Qiaolin Wu, Wei Gao, Jiahao Zhou, Guoliang He, Junxin Ye, Fuquan Fang, Junwei Luo, Mengcong Wang, Han Xu, Weijian Wang
MICROVASCULAR RESEARCH
(2019)
Article
Anesthesiology
Yi He, Jinfeng Wei, Jinjun Bian, Kefang Guo, Jiakai Lu, Wei Mei, Jun Ma, Zhongyuan Xia, Meiying Xu, Fuxia Yan, Chunhua Yu, E. Wang, Weijian Wang, Ni Zeng, Sheng Wang, Junmei Xu, Yuguang Huang, Jiapeng Huang
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2020)
Article
Cardiac & Cardiovascular Systems
Guoliang He, Yuan Gao, Linya Feng, Guodong He, Qiaolin Wu, Wei Gao, Lina Lin, Weijian Wang
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2020)
Letter
Anesthesiology
Jiahao Zhou, Weijian Wang, Jiehao Sun, Qiaolin Wu
JOURNAL OF CLINICAL ANESTHESIA
(2021)
Article
Medicine, General & Internal
Liu Rong-guo, Wang Wei-jian, Song Na, Chen Yan-qing, Li Li-huan
CHINESE MEDICAL JOURNAL
(2006)
Article
Medicine, General & Internal
RG Liu, WJ Wang, AX He, LH Li
CHINESE MEDICAL JOURNAL
(2005)