期刊
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
卷 9, 期 5-6, 页码 405-418出版社
SPRINGER
DOI: 10.1007/s12265-016-9708-y
关键词
Heart disease; Stem cell therapy; Cardiac stem cells; Regenerative medicine
资金
- British Heart Foundation [PG/13/34/30216]
- British Heart Foundation [PG/13/34/30216] Funding Source: researchfish
- Rosetrees Trust [M315] Funding Source: researchfish
When stressed by ageing or disease, the adult human heart is unable to regenerate, leading to scarring and hypertrophy and eventually heart failure. As a result, stem cell therapy has been proposed as an ultimate therapeutic strategy, as stem cells could limit adverse remodelling and give rise to new cardiomyocytes and vasculature. Unfortunately, the results from clinical trials to date have been largely disappointing. In this review, we discuss the current status of the field and describe various limitations and how future work may attempt to resolve these to make way to successful clinical translation.
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