Review
Biochemistry & Molecular Biology
Klara Komici, Angelica Perna, Germano Guerra
Summary: Frailty is a clinical condition characterized by a decline in biological reserves, physiological mechanism failure, and vulnerability to stressors. This review focuses on the role of endothelial progenitor cells (EPCs) in frailty, highlighting their impaired function, number, and survival in the elderly. It also discusses the modification of EPCs in age-related diseases such as atherosclerosis, hypertension, and diabetes mellitus. The review concludes by exploring interventions that may restore EPCs expression and function in frail individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Tays Amanda Felisberto Goncalves, Viviane Silva Lima, Arthur Jose Pontes Oliveira de Almeida, Alinne Villar de Arruda, Ana Caroline Meneses Ferreira Veras, Thais Trajano Lima, Evyllen Myllena Cardoso Soares, Adhonias Correia dos Santos, Maria Eduarda Costa de Vasconcelos, Mathania Silva de Almeida Feitosa, Robson Cavalcante Veras, Isac Almeida de Medeiros
Summary: This study demonstrated the regulatory effects of carvacrol on endothelial repair in spontaneously hypertensive rats. Results showed that carvacrol promoted the migration and proliferation of endothelial progenitor cells, increased eNOS expression and activity, reduced reactive oxygen species production and cellular senescence, and improved vascular function.
Article
Cell Biology
Ze-Hui Shi, Xiao-Yan Han, Mu-Di Yao, Chang Liu, Qin Jiang, Biao Yan
Summary: This study identified 72 miRNAs that were differentially expressed in EPCs following high glucose stress, with target genes involved in protein binding, cell differentiation, and cytoskeleton based on GO analysis. KEGG pathway analysis revealed the association between cGMP-PKG signaling pathway and miRNA-mediated EPC function. The up-regulation of miR-375-3p in clinical samples of DR patients was verified, and its inhibition protected EPCs against hyperglycemic or hypoxic stress-induced injury, enhancing cell viability, proliferation, migration, tube formation ability, and delaying apoptosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ewa Rudnicka-Drozak, Paulina Drozak, Grzegorz Mizerski, Martyna Drozak
Summary: Endothelial progenitor cells (EPCs) play an important role in neurovascular disorders and have potential therapeutic applications. Decreased levels of EPCs are associated with worse disease outcomes. EPCs show promising safety and efficacy in the treatment of Alzheimer's disease and ischemic stroke.
Review
Cell & Tissue Engineering
Josefa Benitez-Camacho, Antonio Ballesteros, Lucia Beltran-Camacho, Marta Rojas-Torres, Antonio Rosal-Vela, Margarita Jimenez-Palomares, Ismael Sanchez-Gomar, M. Carmen Duran-Ruiz
Summary: This article analyzes the relationship between diabetes and diabetic vascular complications, focusing on the potential use of endothelial progenitor cells (EPCs) as biomarkers for predicting the development of major vascular complications in diabetic patients. The effects of different drugs on the number and function of EPCs are also discussed.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Sonia Terriaca, Elena Fiorelli, Maria Giovanna Scioli, Giulia Fabbri, Gabriele Storti, Valerio Cervelli, Augusto Orlandi
Summary: Endothelial progenitor cell (EPC)-derived extracellular vesicles (EVs) play a crucial role in tissue regeneration and repair, showing potential for cell-free biological therapy. They can deliver different molecules to target tissues and have been studied and applied in various medical conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Isra Marei, Blerina Ahmetaj-Shala, Chris R. Triggle
Summary: Stent thrombosis is a common complication in patients with type 2 diabetes undergoing percutaneous coronary intervention, and it is caused by delayed and impaired endothelialization of the stent. Using specific molecules to induce endothelial cell adhesion, proliferation, and function can improve stent endothelialization and prevent thrombosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Klara Komici, Angelica Perna, Aldo Rocca, Leonardo Bencivenga, Giuseppe Rengo, Germano Guerra
Summary: Rheumatoid Arthritis is a chronic autoimmune inflammatory disease that can lead to endothelial damage and dysfunction. Endothelial Progenitor Cells play a crucial role in vascular homeostasis and repair, but there are conflicting results regarding their number and function in RA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Dhivya Vadhana Meenakshi-Siddharthan, Christopher Livia, Timothy E. Peterson, Paul Stalboerger, Zachi I. Attia, Alfredo L. Clavell, Paul A. Friedman, Suraj Kapa, Peter A. Noseworthy, Marissa J. Schafer, John M. Stulak, Atta Behfar, Barry A. Boilson
Summary: The objective of this study was to investigate whether heart failure (HF) is an age-independent senescent phenomenon and how it is reflected at a molecular level in the circulating progenitor cell niche and at a substrate level using an AI-based ECG platform. CD34+ progenitor cells were analyzed and isolated from patients with different stages of HF and healthy controls. The results showed that HF is associated with cellular and molecular evidence of senescence, and the AI-based ECG can detect a phenotype of cardiac aging beyond chronological age.
MAYO CLINIC PROCEEDINGS
(2023)
Article
Biochemistry & Molecular Biology
Zhengjian Yan, Lei Chu, Xiaojiong Jia, Lu Lin, Si Cheng
Summary: Stem cell therapy using neural progenitor cells (NPCs) shows promise in mitigating the effects of spinal cord injury, with myelin playing a role in promoting axonal regeneration. The study identified the serine protease myelin basic protein (Mbp) as a key gene involved in myelin-associated axonal regeneration. In vivo experiments using murine NPCs overexpressing Mbp demonstrated enhanced locomotive recovery and axonal regeneration post-SCI, suggesting that bioengineered NPC-based interventions can support axonal regeneration and functional recovery.
CELL AND BIOSCIENCE
(2021)
Review
Cell & Tissue Engineering
Amankeldi A. Salybekov, Mehdi Hassanpour, Shuzo Kobayashi, Takayuki Asahara
Summary: Chronic diseases and associated risk factors can negatively affect the function of regenerative cells and the regenerative microenvironment. The vasculogenic conditioning culture (VCC) method has been developed to enhance the regenerative microenvironment and generate regeneration-associated cells (RACs), which consist of vasculogenic endothelial progenitor cells (EPCs) and anti-inflammatory/anti-immunity cells. Both preclinical and clinical studies have shown that RAC transplantation is a safe and effective approach for promoting tissue recovery in ischemic conditions. This comprehensive review highlights the universal features of RACs and the latest advancements in their translation to clinical applications.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Geriatrics & Gerontology
Antia Custodia, Alberto Ouro, Daniel Romaus-Sanjurjo, Juan Manuel Pias-Peleteiro, Helga E. de Vries, Jose Castillo, Tomas Sobrino
Summary: Alzheimer's disease is a neurodegenerative disease with a complex and unknown etiology. The two-hit vascular hypothesis suggests that brain vascular damage leads to the accumulation of beta-amyloid protein. Research has shown that endothelial progenitor cells play a significant role in understanding the disease etiology and developing potential therapies.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Critical Care Medicine
Jennifer A. Munley, Lauren S. Kelly, Gwendolyn S. Gillies, Kolenkode B. Kannan, Erick E. Pons, Letitia E. Bible, Philip A. Efron, Alicia M. Mohr
Summary: Severe trauma disrupts bone marrow function, resulting in persistent anemia and immunosuppression. Exosomes, which are extracellular vesicles, have been implicated in various diseases and cellular functions. This study investigates the effects of trauma plasma-derived exosomes on bone marrow hematopoiesis and explores the potential mechanisms underlying the altered bone marrow function after severe trauma.
Review
Medicine, General & Internal
Erica Rocco, Maria Chiara Grimaldi, Alessandro Maino, Luigi Cappannoli, Daniela Pedicino, Giovanna Liuzzo, Luigi Marzio Biasucci
Summary: Coronary microvascular dysfunction (CMD) is often underdiagnosed and its clinical importance underestimated, with invasive and expensive techniques currently used for measurement. Research on potential biomarkers linked to microvascular dysfunction could improve diagnosis, risk stratification, disease progression, and therapy response.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Xin Shi, Kelly A. Seidle, Kevin J. Simms, Feng Dong, William M. Chilian, Ping Zhang
Summary: Extensive injury of endothelial cells in sepsis and systemic inflammation is caused by pathological factors such as microbial toxins, oxidative stress, and inflammatory mediators. The failure of endothelial barrier function leads to microcirculatory collapse and tissue edema, which can be fatal. The activation of endothelial progenitor cells (EPCs) in response to septic challenges and their recruitment to injured tissues contribute to endothelial repair and angiogenesis. Understanding the molecular signaling mechanisms underlying the EPC response offers potential approaches for preventing and treating sepsis-induced vascular injury and organ failure.
PHARMACOLOGY & THERAPEUTICS
(2023)
