Melatonin enhances sensitivity to fluorouracil in oesophageal squamous cell carcinoma through inhibition of Erk and Akt pathway

Melatonin enhancement of the radiosensitivity of human breast cancer cells is associated with the modulation of proteins involved in estrogen biosynthesis

(2016) Carolina Alonso-González et al.   CANCER LETTERS

DESC1, a novel tumor suppressor, sensitizes cells to apoptosis by downregulating the EGFR/AKT pathway in esophageal squamous cell carcinoma

(2016) Hoi Yan Ng et al.   INTERNATIONAL JOURNAL OF CANCER

Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses

(2015) Mauricio F. Farez et al.   CELL

Recent Advances From Basic and Clinical Studies of Esophageal Squamous Cell Carcinoma

(2015) Shinya Ohashi et al.   GASTROENTEROLOGY

Melatonin overcomes gemcitabine resistance in pancreatic ductal adenocarcinoma by abrogating nuclear factor-κB activation

(2015) Huai-Qiang Ju et al.   JOURNAL OF PINEAL RESEARCH

HDAC1 inhibition by melatonin leads to suppression of lung adenocarcinoma cells via induction of oxidative stress and activation of apoptotic pathways

(2015) Chongxi Fan et al.   JOURNAL OF PINEAL RESEARCH

High EGFR and low p-Akt expression is associated with better outcome after nimotuzumab-containing treatment in esophageal cancer patients: preliminary clinical result and testable hypothesis

(2015) Chun-yu Wang et al.   Oncotarget

Adhesion glycoprotein CD44 functions as an upstream regulator of a network connecting ERK, AKT and Hippo-YAP pathways in cancer progression

(2015) Shiyi Yu et al.   Oncotarget

Stemness and chemotherapeutic drug resistance induced by EIF5A2 overexpression in esophageal squamous cell carcinoma

(2015) Hong Yang et al.   Oncotarget

Suppression of esophageal tumor growth and chemoresistance by directly targeting the PI3K/AKT pathway

(2015) Bin Li et al.   Oncotarget

Circadian and Melatonin Disruption by Exposure to Light at Night Drives Intrinsic Resistance to Tamoxifen Therapy in Breast Cancer

(2014) R. T. Dauchy et al.   CANCER RESEARCH

Melatonin: functions and ligands

(2014) Mahaveer Singh et al.   DRUG DISCOVERY TODAY

Identification of MicroRNA-214 as a negative regulator of colorectal cancer liver metastasis by way of regulation of fibroblast growth factor receptor 1 expression

(2014) Dong-liang Chen et al.   HEPATOLOGY

Melatonin: a well-documented antioxidant with conditional pro-oxidant actions

(2014) Hong-Mei Zhang et al.   JOURNAL OF PINEAL RESEARCH

Genomic and molecular characterization of esophageal squamous cell carcinoma

(2014) De-Chen Lin et al.   NATURE GENETICS

Esophageal Carcinoma

(2014) Anil K. Rustgi et al.   NEW ENGLAND JOURNAL OF MEDICINE

MiR-194 Deregulation Contributes To Colorectal Carcinogenesis via Targeting AKT2 Pathway

(2014) Hui-Jun Zhao et al.   Theranostics

ERK2-dependent reactivation of Akt mediates the limited response of tumor cells with constitutive K-RAS activity to PI3K inhibition

(2013) Mahmoud Toulany et al.   CANCER BIOLOGY & THERAPY

Oesophageal carcinoma

(2013) Arjun Pennathur et al.   LANCET

PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1

(2013) H. Ebi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the PI3K signaling pathway in cancer therapy

(2012) Chandra Bartholomeusz et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells

(2012) Jingshu Wang et al.   JOURNAL OF PINEAL RESEARCH

Mammalian MAPK Signal Transduction Pathways Activated by Stress and Inflammation: A 10-Year Update

(2012) John M. Kyriakis et al.   PHYSIOLOGICAL REVIEWS

Use of Multimodality Neoadjuvant Therapy for Esophageal Cancer in the United States: Assessment of 987 Hospitals

(2011) Ryan P. Merkow et al.   ANNALS OF SURGICAL ONCOLOGY

A Randomized Trial Comparing Postoperative Adjuvant Chemotherapy with Cisplatin and 5-Fluorouracil Versus Preoperative Chemotherapy for Localized Advanced Squamous Cell Carcinoma of the Thoracic Esophagus (JCOG9907)

(2011) Nobutoshi Ando et al.   ANNALS OF SURGICAL ONCOLOGY

Insulin-like growth factor 1 mediates 5-fluorouracil chemoresistance in esophageal carcinoma cells through increasing survivin stability

(2010) Hsien-Chia Juan et al.   APOPTOSIS

Triterpenes augment the inhibitory effects of anticancer drugs on growth of human esophageal carcinoma cellsin vitroand suppress experimental metastasisin vivo

(2009) Hiromichi Yamai et al.   INTERNATIONAL JOURNAL OF CANCER

Genetic Variations in the PI3K/PTEN/AKT/mTOR Pathway Are Associated With Clinical Outcomes in Esophageal Cancer Patients Treated With Chemoradiotherapy

(2009) Michelle A.T. Hildebrandt et al.   JOURNAL OF CLINICAL ONCOLOGY

Targeting NF- B signaling pathway suppresses tumor growth, angiogenesis, and metastasis of human esophageal cancer

(2009) B. Li et al.   MOLECULAR CANCER THERAPEUTICS