Article
Biochemistry & Molecular Biology
Jang Mi Han, Hong Lae Kim, Hye Jin Jung
Summary: Ampelopsin (dihydromyricetin), a plant-derived flavonoid, significantly inhibits the proliferation of two leukemia cell lines while not affecting the viability of normal cells. Its anticancer effects include cell cycle regulation, induction of apoptosis, and downregulation of signaling pathways. Ampelopsin shows promise as an attractive chemotherapeutic agent against leukemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Jianan Zhang, Qi Shen, Lu Xia, Xueqiong Zhu, Xuejie Zhu
Summary: This study investigated the role of DYNLT3 protein in cervical cancer and its molecular mechanisms. The results showed that DYNLT3 inhibited cell proliferation, migration, and invasion in cervical cancer, and promoted apoptosis. It was also found that DYNLT3 suppressed the expression of Wnt signaling pathway and EMT-related proteins. Furthermore, upregulation of DYNLT3 expression inhibited tumor growth and metastasis in vivo.
FRONTIERS IN ONCOLOGY
(2022)
Article
Plant Sciences
Meng-Lian Zhu, Jian-Chun Li, Lu Wang, Xia Zhong, Yu-Wei Zhang, Rui-Zhi Tan, Hong-Lian Wang, Jun-Ming Fan, Li Wang
Summary: The study found that decursin can induce apoptosis, inhibit cell proliferation and migration in HeLa cells, and also inhibit tumor growth in vivo, possibly through the regulation of Akt activation. These findings may have implications for novel therapeutic strategies for cervical cancer.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2021)
Article
Cell Biology
Marika Rossini, Fernanda Martini, Elena Torreggiani, Francesca Fortini, Giorgio Aquila, Francesco Vieceli Dalla Sega, Simone Patergnani, Paolo Pinton, Pio Maniscalco, Giorgio Cavallesco, Paola Rizzo, Mauro Tognon
Summary: Malignant pleural mesothelioma is an aggressive cancer linked to asbestos exposure with poor prognosis. Dysregulation of Notch signaling may contribute to cancer progression. Metformin is an effective anti-tumor drug, showing inhibitory effects on MPM cell proliferation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Plant Sciences
Jirapak Ruttanapattanakul, Nitwara Wikan, Kittinan Chinda, Thanathorn Jearanaikulvanich, Napatsorn Krisanuruks, Muantep Muangcha, Siriporn Okonogi, Saranyapin Potikanond, Wutigri Nimlamool
Summary: The essential oil of Zingiber ottensii showed significant apoptotic effects on cervical cancer cells and reduced IL-6 levels. It induced apoptotic death through caspase activation and suppressed the EGF-induced pAkt and pERK1/2 signaling pathways.
Article
Biotechnology & Applied Microbiology
Chenglu Zhu, Cuilan Zhang, Xiaoming Cui, Jing Wu, Zhizhu Cui, Xiaojuan Shen
Summary: The natural compound trichosanthin (TCS) shows potential as an antiviral and anti-tumor agent in cervical cancer by inhibiting cell viability, proliferation, migration, and invasion while inducing apoptosis, possibly through the regulation of oxidative stress.
Article
Medicine, Research & Experimental
Jiali Shi, Shanshan Sun, Shuqiao Xing, Changgang Huang, Yuqian Huang, Qian Wang, Xiumin Xue, Zhichao Chen, Yongjie Wang, Zhihui Huang
Summary: Fraxinellone was found to inhibit the proliferation and growth of GBM cells in vitro, as well as suppress their migration and induce apoptosis. The mechanism of action involved the downregulation of SIRT3 signaling and the inhibition of GBM tumorigenesis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Genetics & Heredity
Qian Yang, Shan Tian, Zhengru Liu, Weiguo Dong
Summary: This study revealed that RIPK2 is overexpressed in gastric cancer and downregulating RIPK2 in GC cells can suppress cell growth, migration, and induce apoptosis through the NF-κB signaling pathway. RIPK2 functions as a potential oncogene in modulating GC cell proliferation, migration, and apoptosis. These findings suggest that RIPK2 could serve as a candidate biomarker, diagnostic tool, and therapeutic target for GC.
FRONTIERS IN GENETICS
(2021)
Article
Nanoscience & Nanotechnology
Jianwen Li
Summary: Brassinin, a plant antibiotic, inhibits proliferation and induces apoptosis in gastric cancer cells by regulating the NF-KB signaling pathway.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Jianyong Dong, Jun Cui, Xuanxuan Shi, Tao Wang, Shaohua Liu
Summary: This study demonstrates that itraconazole inhibits the proliferation and angiogenesis of HemECs through the downregulation of the HH signaling pathway and induces apoptosis. Therefore, itraconazole could be an effective treatment option for IH.
Article
Oncology
Shanshan Sun, Jiali Shi, Xin Wang, Changgang Huang, Yuqian Huang, Jiayun Xu, Yuanyuan Jiang, Liying Cao, Tian Xie, Yongjie Wang, Zhihui Huang
Summary: Atractylon can inhibit proliferation and migration, as well as induce apoptosis in GBM cells by up-regulating SIRT3, suggesting it as a potential strategy for the treatment of GBM.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Wenjun Li, Xuechao Xu, Yixin Wan, Hong Wang, Hongyan Tao, Huirong Huang
Summary: Cynaropicrin exerts anti-proliferative and proapoptotic effects on H1975 and H460 lung cancer cells by deactivating the EGFR/AKT signaling pathway. It also upregulates the expressions of miR-202 and miR-370 in these cells, indicating its potential for lung cancer treatment.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Manal Alfwuaires, Hany Elsawy, Azza Sedky
Summary: This study suggests that ACN can inhibit the activation of STAT3 and suppress the expression of genes associated with HCC, making it a promising therapeutic compound for the treatment of HCC and other cancers.
Article
Oncology
Zhongrui Wang, Xiqian Zhou, Xiaochong Deng, Danrong Ye, Diya Liu, Baian Zhou, Wenfang Zheng, Xuehui Wang, Yuying Wang, Oyungerel Borkhuu, Lin Fang
Summary: Breast cancer is the most common cancer type in women worldwide. This study demonstrates that miR-186-5p inhibits proliferation and induces apoptosis in breast cancer cells by targeting ANXA9. These findings provide a potential therapeutic target for breast cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Ling Lin, Youwen Xu, Hongfei Ge, Susu He, Peng Wang
Summary: The study reveals that CHD4 plays a crucial role in repressing apoptosis and promoting cancer development in lung adenocarcinoma. Functional analyses show that CHD4 can elevate the levels of PHF6, thereby enhancing the proliferation of LAC cells and suppressing their apoptosis.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Oncology
Bikash Chandra Jena, Chandan Kanta Das, Indranil Banerjee, Deblina Bharadwaj, Ranabir Majumder, Subhayan Das, Angana Biswas, Moumita Kundu, Pritam Kumar Roy, Chanakya Nath Kundu, Mahitosh Mandal
Summary: This study reveals the important role of Transforming growth factor-beta 1 (TGF-beta 1) in the tumor microenvironment and its interaction with cancer-associated fibroblasts (CAFs). The research shows that hypoxia and TGF-beta 1 induce autophagy in CAFs, leading to the supply of lactate to cancer cells and upregulation of aerobic glycolysis and monocarboxylate transporter (MCT4) expression in CAFs. Autophagy is also involved in the epithelial-mesenchymal transition (EMT) in hypoxic CAFs, promoting tumor migration and metastasis through the reverse Warburg effect.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Koushik Bhattacharya, Subhayan Das, Moumita Kundu, Sudarshan Singh, Uddhab Kalita, Mahitosh Mandal, Nikhil K. Singha
Summary: This study demonstrates the synthesis of a block copolymer containing water-soluble photosensitizer and anticancer drug. When anchored on gold nanoparticles, the hybrid system exhibits triggered drug release and reactive oxygen species generation, showing promising cytotoxic effects on breast cancer cells.
MACROMOLECULAR BIOSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
K. Deepak, Pritam Kumar Roy, Prithwish Kola, Budhaditya Mukherjee, Mahitosh Mandal
Summary: Kinins are bioactive peptides involved in cancer progression and inflammatory response. They activate kinin receptors and receptor tyrosine kinases to regulate multiple signaling pathways and contribute to cancer hallmarks. In the tumor microenvironment, kinins activate fibroblasts, interact with mesenchymal stem cells, and recruit immune cells. Kinin receptor antagonists show anti-metastatic potential.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Oncology
Angana Biswas, Yetirajam Rajesh, Subhayan Das, Indranil Banerjee, Neelkamal Kapoor, Pralay Mitra, Mahitosh Mandal
Summary: Fusion genes result from chromosomal abnormalities, with ETV6-NTRK3 fusion protein activating pathways leading to cancer, highlighting the need for targeted therapy.
Article
Polymer Science
Koushik Bhattacharya, Moumita Kundu, Subhayan Das, Sarthik Samanta, Sib Sankar Roy, Mahitosh Mandal, Nikhil K. Singha
Summary: A functional fluorescent sensor has been developed in this study, which can distinguish cancer cells from normal cells by monitoring the pH change.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Mohor Mitra, Pannem Venkatesh, Upashana Ghissing, Angana Biswas, Adinpunya Mitra, Mahitosh Mandal, Hari Niwas Mishra, Mrinal K. Maiti
Summary: The endophytic yeast-like fungus Geotrichum candidum PF005 emits fruity scented volatile organic compounds that have significant antifungal activity. In this study, 13 out of 28 fungal isolates from stored grains of rice and wheat showed growth inhibition of 41% to 87% in the presence of the volatile mixture, demonstrating its broad-spectrum bioactivity. The volatile mixture affected the chitin distribution and mycelial/spore morphology in two test fungi, Rhizoctonia solani and Curvularia oryzae, and caused increased oxidative stress. Five different solid-state media formulations were developed to utilize the antifungal volatile mixture for mycofumigation against the phytopathogens, with one formulation showing maximum growth inhibition due to the production of ethyl isovalerate.
BIOLOGICAL CONTROL
(2023)
Article
Chemistry, Multidisciplinary
Amrita Chaudhuri, Tara Singha, Bikash Chandra Jena, Maniklal Shee, Prasanta Kumar Datta, Mahitosh Mandal, N. D. Pradeep Singh
Summary: The study focuses on light-activated H2S donors, which are of great interest in understanding the physiological role and clinical potential of H2S due to their localized and controlled release. Researchers have developed a fluorescent organic nanosystem based on the HPQ chromophore that can tolerate oxidative stress and precisely release H2S under one- and two-photon irradiation. The nanosystem also allows real-time monitoring of the H2S release. This nanoprodrug shows promise for releasing H2S as a gasotransmitter in living systems under laser irradiation in a phototherapeutic window.
CHEMICAL COMMUNICATIONS
(2023)
Article
Environmental Sciences
Trisita Ghosh, Suvendu Nandi, Swarup Krishna Bhattacharyya, Suman Kumar Ghosh, Mahitosh Mandal, Pallab Banerji, Narayan Ch Das
Summary: This study developed photoluminescent heteroatom-doped carbon dots for cancer cell imaging through a simple hydrothermal procedure. The carbon dots exhibited spherical shape with an average diameter of 3.5 nm. They showed low cytotoxicity and good compatibility with normal glial cells, and were able to emit green fluorescence inside cells with imaging-trackable ability.
ENVIRONMENTAL RESEARCH
(2023)
Article
Spectroscopy
Nishant Kumar Choudhary, Lavanya L. Mittapelli, Pritam Kumar Roy, Gourav Das, Mahitosh Mandal, Kiran R. Gore
Summary: In this study, a vinyl substituted triphenylamine (TPA-alk) fluorescent probe was developed for the rapid and efficient detection of mercury ion (Hg2+) in water and biological environments. The probe showed selective detection of Hg2+ over a wide range of competitive metal ions and exhibited a blue shift in the UV absorbance spectrum. The detection limit was found to be 0.146 mu M (29.2 ppb) with high selectivity. The probe also showed biocompatibility and low cytotoxicity, making it suitable for cell imaging studies.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Review
Nanoscience & Nanotechnology
Prithwish Kola, Prasanth Kumar Bhusetty Nagesh, Pritam Kumar Roy, K. Deepak, Rui Luis Reis, Subhas C. Kundu, Mahitosh Mandal
Summary: The increasing number of breast cancer cases globally and the rising death rate indicate the inadequacy of traditional and current treatments. Nanoparticle-based therapies such as photothermal therapy, photodynamic therapy, chemodynamic therapy, and sonodynamic therapy show promise in combating breast cancer through accurate drug delivery and elimination of cancer stem cells. These innovative therapies have fewer side effects compared to standard chemotherapy and address the stability issues associated with cancer immunotherapy. This review discusses various nanotheranostic systems and smart nanoparticles, their mechanisms of action, and their relevance in the current era.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Subhayan Das, Koushik Bhattacharya, Jonny J. Blaker, Nikhil K. Singha, Mahitosh Mandal
Summary: In recent years, mucoadhesive drug delivery systems have become increasingly popular in treating oral cancer. Despite significant advances in cancer therapeutics, improving the prognosis of late-stage oral cancer remains challenging. Targeted therapy using mucoadhesive polymers can enhance oral mucosa bioavailability, improve drug distribution and tissue targeting, and minimize systemic side effects, thereby improving the overall outcome of oral cancer patients. Mucoadhesive polymers can be delivered through various formulations and offer adaptability for delivering a range of medicines. This review explores the potential applications of mucoadhesive polymers in treating oral cancer and examines recent research in this field.
Article
Oncology
Moumita Kundu, Subhayan Das, Chandan Kanta Das, Gaurav Kulkarni, Soumen Das, Dibakar Dhara, Mahitosh Mandal
Summary: Glioma is difficult to treat due to its invasive nature and the blood-brain barrier. This study discovered that Magnolol, a neolignan, plays an important role in inducing apoptosis and modulating autophagy in glioma cells. The study also found that Magnolol inhibits the PI3K/AKT/mTOR pathway to induce autophagy. The results suggest that Magnolol could be a promising therapeutic agent for glioma management.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Rajalaxmi Pradhan, Subarno Paul, Biswajit Das, Saptarshi Sinha, Somya Ranjan Dash, Mahitosh Mandal, Chanakya Nath Kundu
Summary: Cancer-associated fibroblasts (CAFs) are highly abundant components in the tumor microenvironment (TME) that secrete cytokines to promote tumor progression and metastasis. This study investigated the potential of cytokines in the formation of cancer stem cells (CSCs) in oral cancer cells and evaluated the anti-inflammatory and anti-carcinogenic effect of Resveratrol-nanoparticle (Res-NP). The results showed that CXCL-12 and IL-6 secreted by CAFs significantly promoted CSCs growth and metastasis, while Res-NP inhibited their secretion and reduced CSCs growth and proliferation. This study suggests that targeting CXCL-12 and IL-6 with Res-NP can inhibit carcinogenesis and metastasis in oral cancer.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Moumita Kundu, Subhayan Das, Suvendu Nandi, Dibakar Dhara, Mahitosh Mandal
Summary: The study found that magnolol (MGN) enhances the therapeutic effect of temozolomide (TMZ) on glioma. MGN promotes glioma cell apoptosis induced by TMZ by inhibiting NF-xB pathway-mediated MGMT activation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Chemistry, Multidisciplinary
Suvankar Banerjee, Sandip Kumar Baidya, Balaram Ghosh, Suvendu Nandi, Mahitosh Mandal, Tarun Jha, Nilanjan Adhikari
Summary: In this study, a quantitative structural assessment of meprin beta inhibitors was performed using non-linear pattern recognition techniques and binding mode analysis. The study identified various structural attributes and designed highly effective inhibitors for meprin beta. Molecular dynamics simulation also confirmed the stability of these inhibitors at the active site. Therefore, this study provides valuable tools for identifying and designing potent inhibitors for meprin beta-related pathophysiological conditions.
NEW JOURNAL OF CHEMISTRY
(2023)