praja2 regulates KSR1 stability and mitogenic signaling

miR-23a, miR-24 and miR-27a protect differentiating ESCs from BMP4-induced apoptosis

(2014) A Musto et al.   CELL DEATH AND DIFFERENTIATION

Reorganization of Enhancer Patterns in Transition from Naive to Primed Pluripotency

(2014) Christa Buecker et al.   Cell Stem Cell

Role of the SIK2–p35–PJA2 complex in pancreatic β-cell functional compensation

(2014) Jun-Ichi Sakamaki et al.   NATURE CELL BIOLOGY

Targeting RAS–ERK signalling in cancer: promises and challenges

(2014) Ahmed A. Samatar et al.   NATURE REVIEWS DRUG DISCOVERY

KSR1 regulates BRCA1 degradation and inhibits breast cancer growth

(2014) J Stebbing et al.   ONCOGENE

Proteolytic control of neurite outgrowth inhibitor NOGO-A by the cAMP/PKA pathway

(2014) M. Sepe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis Tool Web Services from the EMBL-EBI

(2013) Hamish McWilliam et al.   NUCLEIC ACIDS RESEARCH

ERK2 Suppresses Self-Renewal Capacity of Embryonic Stem Cells, but Is Not Required for Multi-Lineage Commitment

(2013) William B. Hamilton et al.   PLoS One

Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth

(2013) Luca Lignitto et al.   Nature Communications

Suppression of Ras/Mapk pathway signaling inhibits Myc-induced lymphomagenesis

(2012) M W Gramling et al.   CELL DEATH AND DIFFERENTIATION

BMP4 Signaling Acts via Dual-Specificity Phosphatase 9 to Control ERK Activity in Mouse Embryonic Stem Cells

(2012) Zhongwei Li et al.   Cell Stem Cell

KSR1 Is Overexpressed in Endometrial Carcinoma and Regulates Proliferation and TRAIL-Induced Apoptosis by Modulating FLIP Levels

(2011) David Llobet et al.   AMERICAN JOURNAL OF PATHOLOGY

RAF Inhibitor-Induced KSR1/B-RAF Binding and Its Effects on ERK Cascade Signaling

(2011) Melissa M. McKay et al.   CURRENT BIOLOGY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK

(2011) Damian F. Brennan et al.   NATURE

Control of PKA stability and signalling by the RING ligase praja2

(2011) Luca Lignitto et al.   NATURE CELL BIOLOGY

PKA regulatory subunits mediate synergy among conserved G-protein-coupled receptor cascades

(2011) Eduard Stefan et al.   Nature Communications

Pharmacologic Inactivation of Kinase Suppressor of Ras1 Sensitizes Epidermal Growth Factor Receptor and Oncogenic Ras-Dependent Tumors to Ionizing Radiation Treatment

(2010) H. Xiao et al.   MOLECULAR CANCER THERAPEUTICS

AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade

(2010) F. Donelson Smith et al.   NATURE CELL BIOLOGY

Differentiation of Embryonic Stem Cells 1 (Dies1) Is a Component of Bone Morphogenetic Protein 4 (BMP4) Signaling Pathway Required for Proper Differentiation of Mouse Embryonic Stem Cells

(2009) Luigi Aloia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KSR2 Is a Calcineurin Substrate that Promotes ERK Cascade Activation in Response to Calcium Signals

(2009) Michele K. Dougherty et al.   MOLECULAR CELL

A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells

(2009) Hitoshi Niwa et al.   NATURE

Signaling dynamics of the KSR1 scaffold complex

(2009) M. M. McKay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Positive feedback in cellular control systems

(2008) Alexander Y. Mitrophanov et al.   BIOESSAYS

Proteolysis of AKAP121 regulates mitochondrial activity during cellular hypoxia and brain ischaemia

(2008) Annalisa Carlucci et al.   EMBO JOURNAL

The ground state of embryonic stem cell self-renewal

(2008) Qi-Long Ying et al.   NATURE

Diversity of degradation signals in the ubiquitin–proteasome system

(2008) Tommer Ravid et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY