Review
Cell & Tissue Engineering
Nan Hu, Linqing Zou, Cheng Wang, Guoqi Song
Summary: RUNX1T1 plays important roles in acute myeloid leukemia, neuronal development, intestinal development, adipogenesis, angiogenesis, and carcinogenesis, affecting cell fate through transcriptional regulation and signaling pathways.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Engineering, Biomedical
Yangyang Qu, Si He, Shixing Luo, Jinmin Zhao, Ruiming Liang, Chuanan Liao, Li Zheng
Summary: This study reports a novel photocrosslinkable, injectable locust bean gum-methacrylate hydrogel as a biomimetic extracellular matrix for cartilage repair. The hydrogel shows controllable degradation rate, improved mechanical properties, and excellent biocompatibility. In addition, it significantly induces chondrogenic differentiation of bone mesenchymal stem cells in vitro and accelerates cartilage healing in vivo after 8 weeks of therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Cell Biology
Qingyu Zhang, Jun Dong, Peng Zhang, Dongsheng Zhou, Fanxiao Liu
Summary: Key gene regulatory events were identified in early stages of lineage commitment in BMSCs, with two transcription factors (Tsc22d3 and Epas1) showing elevated expression throughout different stages of three-directional differentiation in rats.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Health Care Sciences & Services
Suncica Kapor, Milica Vukotic, Tijana Suboticki, Dragoslava Dikic, Olivera Mitrovic Ajtic, Milica Radojkovic, Vladan P. Cokic, Juan F. Santibanez
Summary: The study found that HU inhibits the growth of BMMSC, causing senescence-like changes and affecting cellular differentiation and immunoregulatory functions.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Multidisciplinary Sciences
Jerome Nicolas Janssen, Valerio Izzi, Elvira Henze, Goekhan Cingoez, Florian Lowen, David Kuettner, Ruth Neumann, Christof Lenz, Vicki Rosen, Nicolai Miosge
Summary: The knockout of RAB5C in CPCs leads to elevated expression of chondrogenic markers and increased COL2 deposition, making RAB5C a promising target for future therapeutic approaches to increase COL2 content in diseased joints.
Article
Immunology
Yang Chen, Hua Huang, Wen Zhong, Lan Li, Yanrong Lu, Hai-bo Si
Summary: This study aimed to investigate the role and potential mechanism of microRNA-140-5p (miR-140-5p) in cartilage progenitor/stem cells (CPCs) fate changes and regulatory mechanisms in osteoarthritis (OA) pathogenesis. The findings revealed that fate changes in OA CPCs were associated with downregulation of miR-140-5p and upregulation of Jagged1 and Notch signals. Furthermore, miR-140-5p was found to protect CPCs by inhibiting Jagged1/Notch signaling, providing attractive targets for OA therapeutics.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Miwa Tanaka, Mizuki Homme, Yasuyo Teramura, Kohei Kumegawa, Yukari Yamazaki, Kyoko Yamashita, Motomi Osato, Reo Maruyama, Takuro Nakamura
Summary: This study aimed to clarify the functional role of HEY1-NCOA2 in the development and progression of mesenchymal chondrosarcoma. They found that introducing HEY1-NCOA2 into mouse embryonic cells successfully induced subcutaneous tumors with biphasic morphologies and the expression of chondrogenic differentiation marker Sox9. The interaction between HEY1-NCOA2 and Runx2 was observed, and treatment with the HDAC inhibitor panobinostat suppressed tumor growth both in vitro and in vivo.
Article
Biochemistry & Molecular Biology
Marija Mazor, Eric Lespessailles, Thomas M. Best, Mazen Ali, Hechmi Toumi
Summary: Recent research has shown that cells isolated from osteoarthritic cartilage have the potential to form hyaline-like cartilage tissue. In this study, the researchers examined the marker expression and chondrogenetic potential of cells from mild, moderate, and severe osteoarthritic tissue. They found that only cells from moderate osteoarthritis were able to form hyaline cartilage-like tissue, while cells from severe and mild osteoarthritis did not. These findings have implications for understanding the repair capacity of articular cartilage in osteoarthritis and suggest that these progenitor cells may be a candidate for cartilage repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Douglas G. Brownfield, Alex Diaz de Arce, Elisa Ghelfi, Astrid Gillich, Tushar J. Desai, Mark A. Krasnow
Summary: The study reveals that FGF signaling plays a critical role in initiating alveolus development in mouse lung by inducing AT2 fate and a secondary signal for AT1 fate, and continuously maintains the existence of AT2 cells throughout life.
NATURE COMMUNICATIONS
(2022)
Article
Cell & Tissue Engineering
M. Teunissen, N. S. Ahrens, L. Snel, R. Narcisi, S. A. Kamali, G. J. V. M. van Osch, B. P. Meij, S. C. Mastbergen, K. Sivasubramaniyan, M. A. Tryfonidou
Summary: The OA environment has adverse effects on the regenerative potential of cSM-MPCs, making them less optimal candidates for the cell-based treatment of OA.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Geriatrics & Gerontology
Christian Morsczeck, Anja Reck, Torsten E. Reichert
Summary: Previous studies have suggested that impaired AMPK activity may have a negative impact on cellular senescence. This study found that inhibition of AMPK induces cellular senescence and inhibits autophagy. Conversely, autophagy inhibition promotes cellular senescence. Surprisingly, inducers of AMPK such as metformin or AICAR increased senescence in DFCs.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Stephanie Simoncini, Simon Toupance, Carlos Labat, Sylvie Gautier, Chloe Dumoulin, Laurent Arnaud, Maria G. Stathopoulou, Sophie Visvikis-Siest, Pascal M. Rossi, Athanase Benetos, Francoise Dignat-George, Florence Sabatier
Summary: This study investigates the relationship between atherosclerotic cardiovascular disease (ASCVD), inflammation markers, and circulating endothelial progenitor cells. The findings suggest that ASCVD impairs the colony forming capacity and angiogenic properties of endothelial colony forming cells (ECFC) in a severity-dependent manner. Additionally, alteration of ECFC is associated with increased senescent phenotype and IL-6 levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Alexia Tasca, Martin Helmstaedter, Magdalena Maria Brislinger, Maximilian Haas, Brian Mitchell, Peter Walentek
Summary: The study found that multiciliated cells can undergo apoptosis or trans-differentiate into goblet secretory cells during developmental tissue remodeling, both processes dependent on Notch signaling and modulated by other signaling pathways.
DEVELOPMENTAL CELL
(2021)
Article
Multidisciplinary Sciences
Xuan Zheng, Max A. Betjes, Pascal Ender, Yvonne J. Goos, Guizela Huelsz-Prince, Hans Clevers, Jeroen S. van Zon, Sander J. Tans
Summary: This study developed a new tool called TypeTracker, which identifies cell fates by AI-enabled cell tracking and propagates end point fates back along the branched lineage trees. The research found that cells commit to their new type early, when still deep inside the crypt, contrary to the conventional belief that cells differentiate as they move up the crypt-villus axis. This study raises new questions about the underlying commitment and sorting mechanisms.
Article
Multidisciplinary Sciences
Jia Q. Ng, Toghrul H. Jafarov, Christopher B. Little, Tongtong Wang, Abdullah M. Ali, Yan Ma, Georgette A. Radford, Laura Vrbanac, Mari Ichinose, Samuel Whittle, David J. Hunter, Tamsin R. M. Lannagan, Nobumi Suzuki, Jarrad M. Goyne, Hiroki Kobayashi, Timothy C. Wang, David R. Haynes, Danijela Menicanin, Stan Gronthos, Daniel L. Worthley, Susan L. Woods, Siddhartha Mukherjee
Summary: Osteoarthritis is characterized by irreversible degeneration of articular cartilage. Gremlin 1 marks a bipotent cell population on the articular surface, which plays a crucial role in chondrogenic and osteogenic progenitor cells. These cells are affected by injury and aging, leading to the development of osteoarthritis.
NATURE COMMUNICATIONS
(2023)
Article
Engineering, Multidisciplinary
Xin Fang, Heng Li, She-rong Zhang, Xiao-hua Wang, Chao Wang, Xiao-chun Luo
Summary: This paper develops advanced deep learning approaches for structural dynamic response prediction and dam health diagnosis. Improved long short-term memory (LSTM) networks are proposed for data-driven analysis of structural dynamic responses. The LSTM-based models are proven to have the potential for quick estimation of structural responses under blast loads. Damage indicators extracted from the predicted velocity histories establish their relationship with the numerical simulation of dam damage. This study provides a deep-learning based framework for quick assessment of dam explosions.
DEFENCE TECHNOLOGY
(2023)
Review
Ergonomics
Maxwell Fordjour Antwi-Afari, Heng Li, Alan Hoi Shou Chan, JoonOh Seo, Shahnawaz Anwer, Hao-Yang Mi, Zezhou Wu, Arnold Yu Lok Wong
Summary: This review systematically analyzed and visualized research on work-related musculoskeletal disorders (WMSDs) among construction workers published between 2000 and 2021. The results identified influential authors and research topics, highlighting the significance of MSDs, ergonomics, and construction in this field. Contributions to WMSD research primarily came from the United States, Hong Kong, and Canada. The review also summarized mainstream research topics, identified research gaps, and proposed future directions.
JOURNAL OF SAFETY RESEARCH
(2023)
Article
Engineering, Electrical & Electronic
Zengcheng Sun, Ping He, Heng Li, Jiannong Cao, Feiqi Deng
Summary: The group consensus of second-order sample multi-agent systems is investigated using a distributed event-triggered mechanism. A consensus protocol is proposed, which is updated only when the event-triggered condition is met and the update only depends on the data collected at the moment of triggering. The sufficient condition for group consensus is obtained, and a differential equation is constructed to avoid the Zeno phenomenon and obtain a minimum positive and lower bound for any two trigger time intervals. The effectiveness is verified through a simulation example.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS
(2023)
Article
Chemistry, Physical
Boshan Zhang, Jiangjiang Yu, Weizhen Chen, Hang Liu, Heng Li, Hong Guo
Summary: This paper investigates the bond failure performance between precast normal concrete (NC) and cast-in situ ultra-high performance concrete (UHPC), emphasizing the influence of interfacial roughness. The results demonstrate that certain interfacial roughness is essential to gain a reliable bond connection between NC and UHPC. The higher strength of the base concrete is beneficial to the bond performance, but the influence on the shear interfacial performance could be offset by that of the interface morphology in the case with high interfacial roughness.
Article
Health Care Sciences & Services
Tiffany H. T. Wong, Kaden S. K. Lee, Sharon M. C. Lo, Mandy M. P. Kan, Crystal Kwan, Emmanuelle Opsommer, Shahnawaz Anwer, Heng Li, Arnold Y. L. Wong, Veronika Schoeb
Summary: This study aimed to investigate the experiences, challenges, concerns, and coping strategies of older women with chronic low back pain (CLBP) in Hong Kong. The findings revealed that CLBP has negative impacts on older women's daily life, both physically and psychologically. They adopted various pain management strategies, with some influenced by the Chinese culture. Family support, as well as social activities and support from elderly community centers, were found to be important factors for their management of CLBP.
Article
Health Care Sciences & Services
Melissa Leung, Mandy M. P. Kan, Hugo M. H. Cheng, Diana E. De Carvalho, Shahnawaz Anwer, Heng Li, Arnold Y. L. Wong
Summary: The use of laptops leads to poor working postures and neck pain among university students. Postural braces have the potential to improve upper back/neck posture and may serve as an ergonomic aid for this population.
Article
Engineering, Environmental
Ziwei Qin, Yi Yang, Qingli Tian, Hao-Yang Mi, Heng Li, Runhao Guo, Ying Wang, Chuntai Liu, Changyu Shen
Summary: Developing protective materials with intelligent and stimuli-responsive properties is essential for safety purposes. However, combining contradictory properties into a single polymer is challenging. In this study, a strain-hardening supramolecular polyurethane nanocomposite (SPN) with high mechanical strength and unique impact protection properties is synthesized by incorporating quadruple hydrogen bonds (H-bonds), disulfide bonds, and modified silica nanoparticles into polyurethane elastomer. This SPN material exhibits high energy absorption efficiency and impact protection properties through the dynamic break and re-form characteristic of quadruple H-bonds and the stress dissipation behavior of nanoparticles.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Manufacturing
Ziran Du, Cheng Zhou, Hao-Yang Mi, Heng Li, Ziwei Qin, Ruyan Xu, Yaming Wang, Chuntai Liu, Changyu Shen
Summary: High-performance electromagnetic interference (EMI) shielding materials with low reflection are urgently needed to address secondary electromagnetic pollution. This study proposes ecoflex-encased gradient MXene-decorated melamine foams (eGMMFs) to achieve both ultra-low reflection and efficient shielding. By designing a gradual increased gradient MXene conductive network and a reflector of reduced graphene oxide, the eGMMF integrates multiple layers for improved impedance matching, loss, and reflection, resulting in an average shielding efficiency of 78.8 dB and a reflection coefficient (R) of 0.022 in the X-band. A record-low R value of 3.84 x 10(-5) at 11.52 GHz is achieved, surpassing previously reported MXene-based shields. Furthermore, the developed eGMMF exhibits remarkable piezoresistive sensing and anti-impacting performance. This work provides new insights and guidance for the development of multifunctional shielding and absorbing materials.
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
(2023)
Article
Automation & Control Systems
Xin Fang, Heng Li, Haitao Wu, Lang Fan, Ting Kong, Yue Wu
Summary: This paper introduces a method based on 360 degrees panoramic images and deep learning for fast end-to-end interior progress evaluation. The proposed method takes only one or two 360 degrees panoramic images as input, estimates key corners, generates and registers room layouts, and semantically segments sparse point cloud. The experimental results show that the proposed method achieves comparable performance against those on public data sets.
ENGINEERING APPLICATIONS OF ARTIFICIAL INTELLIGENCE
(2023)
Article
Automation & Control Systems
Xin Fang, Heng Li, Sherong Zhang, Jikang Zhang, Chao Wang, Xiaohua Wang, Ziao Ma, He Jia
Summary: This study provides an innovative automated underwater inspection analysis scheme using ROV and computer vision techniques to inspect and evaluate the invasion of L. fortunei in water conveyance structures. The scheme improves underwater image quality and accurately detects L. fortunei through image enhancement and segmentation methods.
ENGINEERING APPLICATIONS OF ARTIFICIAL INTELLIGENCE
(2023)
Article
Green & Sustainable Science & Technology
Pan Zhang, Haitao Wu, Heng Li, Botao Zhong, Ivan W. H. Fung, Yiu Yin Raymond Lee
Summary: Efficient information sharing is crucial for the success of Modular integrated Construction (MiC) projects. Blockchain provides powerful solutions to address information barriers and foster trust among MiC stakeholders. However, the construction industry lacks empirical evidence and is cautious about adopting this disruptive technology. This study uses game theory to examine stakeholders' decision-making processes and identifies key factors influencing their decisions, such as diffusion rate value thresholds, benefits of blockchain adoption, government subsidies, and relevant costs. The study also suggests pilot projects and subsidy or incentive policies to enhance stakeholders' perceived values and promote blockchain adoption in MiC projects.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Construction & Building Technology
Zhongya Mei, Maozeng Xu, Heng Li, Zhongyi Huang, Siyu Luo
Summary: Concrete formwork reuse can save costs and reduce resource consumption, and it has recently gained more attention. Cooperation among construction sites in a specific district can facilitate the reuse of idle or underutilized formwork. However, the cooperation method and profit allocation are rarely explored, and the assumption of no contract violations in cooperation is not aligned with reality. This study proposes an applicable cooperation mode that includes optimal alliance establishment, profit allocation based on contracts, and compensation for contract violations.
SUSTAINABLE CITIES AND SOCIETY
(2023)
Article
Engineering, Industrial
Hanyue Yang, Heng Li, Guangbin Wang, Dongping Cao
Summary: This study investigates the impact of employment opportunity and environmental amenity disparities on the interregional migration patterns of construction workers. The findings suggest that the interregional migration of construction workers is primarily driven by disparities in employment opportunities, while disparities in environment amenities play a lesser role.
ENGINEERING CONSTRUCTION AND ARCHITECTURAL MANAGEMENT
(2023)
Article
Engineering, Industrial
Xiaoying Li, Xiujuan Jin, Heng Li, Lulu Gong, Deyang Zhou
Summary: This study investigated the impact of policy interventions on BIM-based project performance. The findings showed that the mandatory BIM policy significantly improved subjective BIM performance and BIM return on investment (ROI). The promotion effect of the policy on BIM-based project performance increased over time, and there was significant heterogeneity in the promotion effect for different stakeholders and organizations of different sizes.
ENGINEERING CONSTRUCTION AND ARCHITECTURAL MANAGEMENT
(2023)
Article
Engineering, Industrial
Tai Wai Kwok, SiWei Chang, Heng Li
Summary: This study investigates client satisfaction with UCWS products in Hong Kong and identifies reduction in construction time and reduction in construction waste as the most important factors influencing client satisfaction.
ENGINEERING CONSTRUCTION AND ARCHITECTURAL MANAGEMENT
(2023)