4.5 Article

Diversity of Neural Precursors in the Adult Mammalian Brain

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COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a018838

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  1. Brain & Behavior Research Foundation (NARSAD)
  2. Simons Foundation Autism Research Initiative (SFARI)
  3. National Institutes of Health [[NIH] NS080913, NS048271, HD069184, S047344, ES021957]
  4. Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
  5. Maryland Stem Cell Research Fund
  6. European Molecular Biology Organization (EMBO) long-term fellowship
  7. Foundation's Parkinson's Disease Program [H-1]

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Aided by advances in technology, recent studies of neural precursor identity and regulation have revealed various cell types as contributors to ongoing cell genesis in the adult mammalian brain. Here, we use stem-cell biology as a framework to highlight the diversity of adult neural precursor populations and emphasize their hierarchy, organization, and plasticity under physiological and pathological conditions.

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