Article
Immunology
Murtadha Q. Ali, Thomas P. Kohler, Gerhard Burchhardt, Andreas Wuest, Nadin Henck, Robert Bolsmann, Franziska Voss, Sven Hammerschmidt
Summary: This study revealed that pneumococcal serine proteases play a significant role in colonization but have a minor impact on pneumonia and invasive diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Infectious Diseases
Leigh M. Howard, Xiang Huang, Wencong Chen, Yuhan Liu, Kathryn M. Edwards, Marie R. Griffin, Yuwei Zhu, Jorge E. Vidal, Keith P. Klugman, Ana I. Gil, Nicole R. Soper, Isaac P. Thomsen, Katherine Gould, Jason Hinds, Claudio F. Lanata, Carlos G. Grijalva
Summary: We investigated the association between nasopharyngeal pneumococcal co-colonization and pneumococcal density in young Peruvian children. Pneumococcal co-colonization was common but not associated with increased pneumococcal density.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Adriano P. Araujo, Maria Leonor S. Oliveira, Eliane N. Miyaji
Summary: Streptococcus pneumoniae colonizes the human nasopharynx asymptomatically, but can cause various diseases. This study demonstrates the important role of PspA and PspC in nasopharyngeal colonization, although their significance may vary between different strains.
MICROBIAL PATHOGENESIS
(2023)
Article
Immunology
Leore Kotler, David Greenberg, Noga Givon-Lavi, Bart Adriaan van der Beek, Ron Dagan, Shalom Ben-Shimol
Summary: The study evaluated the impact of PCV on pneumococcal carriage rates in healthy and sick children aged 6-23 months, showing a decrease in carriage rates in respiratory diseases but not in healthy children and those without respiratory infections. This suggests a reduction in respiratory infections caused by VT with a stable rate of non-VT in non-respiratory cases.
Article
Immunology
Maria G. Dunn, Fernanda C. Lessa, Jacqueline Sanchez, Ramona Cordero, Jesus Feris-Iglesias, Doraliza Cedano, Maria da Gloria Carvalho, Josefina Fernandez, Kristen A. Feemster
Summary: The study investigated pneumococcal colonization in children in the Dominican Republic and found that three years post-PCV13 introduction, vaccine-type colonization rates remained high. The number of doses of PCV13 received by children was associated with their vaccine-type carriage status.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Letter
Infectious Diseases
Paulo Camargos, Eliane Drumond, Cristiana M. Nascimento-Carvalho
Summary: The reduction in pneumococcal meningitis was not solely attributed to PCV implementation, but may also be influenced by various factors such as socioeconomic and healthcare improvements. Furthermore, the uncertainty in diagnosing the etiology of meningitis may limit the assessment of missed cases of pneumococcal meningitis, hindering the evaluation of PCV efficacy.
LANCET INFECTIOUS DISEASES
(2021)
Review
Immunology
Sha Li, Hangeri Liang, Shui-Hao Zhao, Xiao-Yan Yang, Zhong Guo
Summary: This review provides an overview of the advancements made in the development of protein-based pneumococcal vaccines. The key protein vaccine candidates and their vaccination results in animal studies are discussed, as well as the challenges and future directions in protein-based pneumococcal vaccine.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Infectious Diseases
Sarah L. Downs, Courtney P. Olwagen, Lara Van Der Merwe, Susan A. Nzenze, Marta C. Nunes, Shabir A. Madhi
Summary: After 9 years of PCV immunization in South Africa, the prevalence of pneumococcal colonization, especially the serotype 19F, remains high.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Mukesh K. Dherani, Daniel Pope, Terence Tafatatha, Ellen Heinsbroek, Ryan Chartier, Thandie Mwalukomo, Amelia Crampin, Elena Mitsi, Esther L. German, Elissavet Nikolaou, Carla Solorzano, Daniela M. Ferreira, Todd D. Swarthout, Jason Hinds, Kevin Mortimer, Stephen B. Gordon, Neil French, Nigel G. Bruce
Summary: This study aimed to assess the association between exposure to household air pollution and the prevalence and density of S pneumoniae carriage among children. The study found a significant association between household air pollution exposure and the prevalence of nasopharyngeal S pneumoniae carriage, providing empirical evidence for the potential mechanistic association between exposure to household air pollution and childhood pneumonia.
LANCET GLOBAL HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Aditi Apte, Girish Dayma, Hakka Naziat, Linda Williams, Sonali Sanghavi, Jamal Uddin, Anand Kawade, Maksuda Islam, Sanchita Kar, You Li, Moe H. Kyaw, Sanjay Juvekar, Harry Campbell, Harish Nair, Samir K. Saha, Ashish Bavdekar
Summary: This study found that South Asian infants get colonised with pneumococci early in infancy, with the Indian cohort predominantly carrying vaccine serotypes in a PCV naive population, while the Bangladeshi cohort mainly carrying non-vaccine serotypes in a vaccinated population. These local findings are important for informing public health policy and developing higher valent pneumococcal vaccines.
JOURNAL OF GLOBAL HEALTH
(2021)
Review
Immunology
Ninecia R. Scott, Beth Mann, Elaine I. Tuomanen, Carlos J. Orihuela
Summary: Streptococcus pneumoniae is a dangerous bacterial pathogen that causes serious diseases, and although current vaccines have limitations in controlling it completely, it is necessary to improve vaccine strategies to enhance protection.
Article
Immunology
Gail L. Rodgers, Cynthia G. Whitney, Keith P. Klugman
Summary: Pneumococcal conjugate vaccine has successfully reduced the burden of disease and provided herd protection for those who cannot be vaccinated. While widely rolled out in poor countries, there are still many unvaccinated children in middle income countries. Solutions being considered include reducing doses and supporting more affordable vaccine sources.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Immunology
Giuliana S. Oliveira, Maria Leonor S. Oliveira, Eliane N. Miyaji, Tasson C. Rodrigues
Summary: Streptococcus pneumoniae is an important pathogen, and pneumococcal conjugate vaccines have a significant impact on invasive diseases. Serotype replacement may occur after vaccine introduction, but this issue could possibly be addressed by developing serotype-independent vaccines.
Article
Microbiology
Annie R. Abruzzo, Surya D. Aggarwal, Molly E. Sharp, Gavyn Chern Wei Bee, Jeffrey N. Weiser
Summary: Capsule is an important factor in the success of Streptococcus pneumoniae during colonization and transmission. The effect of serotypes on clearance and competitive advantage of the organism in the host is significant. Fratricide mechanism plays a role in determining the dominance of serotypes in the upper respiratory tract. Serotype is also important in the transmission dynamics of the organism between hosts.
Article
Immunology
Kristina L. Bajema, Ryan Gierke, Monica M. Farley, William Schaffner, Ann Thomas, Arthur L. Reingold, Lee H. Harrison, Ruth Lynfield, Kari E. Burzlaff, Susan Petit, Meghan Barnes, Salina Torres, Paula M. Snippes Vagnone, Bernard Beall, Tamara Pilishvili
Summary: The incidence of antibiotic-nonsusceptible invasive pneumococcal disease (NS-IPD) has decreased in the United States after the introduction of 7- and 13-valent pneumococcal conjugate vaccines (PCVs). However, there has been an increase in nonvaccine type NS-IPD, particularly among older adults. The use of higher valency PCVs containing the common nonsusceptible serotypes could help further reduce NS-IPD.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Microbiology
Joseph C. Bryant, Ridge C. Dabbs, Katie L. Oswalt, Lindsey R. Brown, Jason W. Rosch, Keun S. Seo, Janet R. Donaldson, Larry S. McDaniel, Justin A. Thornton
Review
Microbiology
Lance E. Keller, D. Ashley Robinson, Larry S. McDaniel
Article
Immunology
Lance E. Keller, Jessica L. Bradshaw, Haley Pipkins, Larry S. McDaniel
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2016)
Article
Immunology
Haley R. Pipkins, Jessica L. Bradshaw, Lance E. Keller, Larry S. McDaniel
JOURNAL OF INFECTIOUS DISEASES
(2018)
Article
Microbiology
Jessica L. Bradshaw, Haley R. Pipkins, Lance E. Keller, James K. Pendarvis, Larry S. McDaniel
Article
Microbiology
Jessica L. Bradshaw, Armando R. Caballero, Michael A. Bierdeman, Kristen V. Adams, Haley R. Pipkins, Aihua Tang, Richard J. O'Callaghan, Larry S. McDaniel
Article
Immunology
Caleb S. Martin, Jessica L. Bradshaw, Haley R. Pipkins, Larry S. McDaniel
OPEN FORUM INFECTIOUS DISEASES
(2018)
Article
Multidisciplinary Sciences
Haley R. Pipkins, Jessica L. Bradshaw, Lance E. Keller, Edwin Swiatlo, Larry S. McDaniel
Article
Microbiology
Jessica L. Bradshaw, Larry S. McDaniel
Article
Microbiology
Kristopher R. Genschmer, Cintia F. M. Vadesilho, Larry S. McDaniel, Sang-Sang Park, Yvette Hale, Eliane N. Miyaji, David E. Briles
Article
Microbiology
Erin McDevitt, Faidad Khan, Anna Scasny, Courtney D. Thompson, Zehava Eichenbaum, Larry S. McDaniel, Jorge E. Vidal
Article
Immunology
Jorge E. Vidal, Meagan N. Wier, Uriel A. Angulo-Zamudio, Erin McDevitt, Ana G. Jop Vidal, Babek Alibayov, Anna Scasny, Sandy M. Wong, Brian J. Akerley, Larry S. McDaniel
Summary: The study found that deoxycholic acid can kill all tested strains of Streptococcus pneumoniae within a short period of time and has an eradication effect on its colonization in the nasopharynx. The mechanism of action of deoxycholic acid does not involve autolysis and is not effective against oral streptococcal species.
INFECTION AND IMMUNITY
(2021)
Article
Immunology
Larry S. McDaniel, Edwin Swiatlo
Summary: The emergence of COVID-19 has accelerated the development of new vaccine strategies and provided opportunities for reevaluating vaccines for other pathogens, such as Streptococcus pneumoniae. While current pneumococcal vaccines are based on polysaccharides, there is potential in utilizing proteins expressed across all serotypes for more affordable and broadly-protective vaccines.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Microbiology
Courtney D. Thompson, Jessica L. Bradshaw, Wesley S. Miller, Ana G. Jop Vidal, Jorge E. Vidal, Jason W. Rosch, Larry S. McDaniel, Lance E. Keller
Summary: Streptococcus pneumoniae can cause various diseases, but the emergence of nonencapsulated strains poses challenges to vaccination. The AliC and AliD proteins regulate gene expression in pneumococcus, protecting it from complement-mediated clearance by reducing CRP binding.