期刊
JOURNAL OF FUNCTIONAL FOODS
卷 24, 期 -, 页码 492-500出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2016.03.035
关键词
Plasmacytoid dendritic cells (pDCs); Lactococcus lactis JCM5805; Randomized controlled double blind trial; Viperin
资金
- Kirin Co., Ltd.
The effects of heat-killed Lactococcus lactis JCM5805 (JCM5805) on the pathogenesis of common cold and influenza were evaluated. A randomized, placebo-controlled, double-blinded study was conducted and 396 healthy subjects (placebo group n = 205, JCM5805 group n = 191) completed the intervention. Subjects consumed placebo capsules or JCM5805 capsules containing approximately 100 billion cells of heat-killed JCM5805 per day for 12 wk. Significantly fewer incident days were observed in the JCM5805 group than in the placebo group for the symptoms of sore throat (p < 0.05) and cough (p < 0.001). Cell surface expression of HLA-DR on plasmacytoid dendritic cells (pDC) and the expression of VIPERIN in peripheral blood mononuclear cells (PBMCs) were higher post-intervention compared to baseline in the JCM5805 group only (p < 0.05). The expression of IFNA in PBMCs was significantly higher in the JCM5805 group (p < 0.05). These data suggest that the intake of heat-killed JCM5805 stimulated pDC-related anti-viral immunity to mitigate the incidence of common cold and influenza symptoms.(c) 2016 Published by Elsevier Ltd.
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