期刊
JOURNAL OF FUNCTIONAL FOODS
卷 26, 期 -, 页码 565-576出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2016.08.020
关键词
Passion fruit; By-product from food industry; Inflammatory bowel disease; Prebiotic effect
资金
- FAPESP [2012/24262-1]
- Spanish Ministry of Economy and Competitiveness [SAF2011-29648, AGL2015-67995-C3-3-R]
- Junta de Andalucia [AGR-6826, CTS 164]
- European Union
- Instituto de Salud Carlos III
- CNPq [CNPq 300533/2013-6]
Low dietary fibre intake has been associated with inflammatory bowel disease incidence. Passiflora edulis peel is considered to be a functional food because of its level of dietary fibre and polyphenols. Female C57BL/6J mice were assigned to three different groups: healthy, dextran sodium sulphate (DSS)-control, and Passiflora edulis treated. Treatment with P. edulis peel flour (8 mg/mL in the drinking water) started 2 weeks before colitis induction, which was performed by adding DSS in the drinking water (3%) for 5 days. P. edulis peel intake exerted an intestinal anti-inflammatory effect and attenuated the colonic damage caused by the DSS, as shown by the reduced disease activity index (DAI) values and after histological evaluation. Biochemical and molecular analyses revealed reduced expression of pro-inflammatory cytokine expression and enhanced intestinal protective barrier. Besides these effects, increases in short-chain fatty acid formation were observed, thus supporting a prebiotic effect. (C) 2016 Elsevier Ltd. All rights reserved.
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