期刊
JOURNAL OF FUNCTIONAL FOODS
卷 22, 期 -, 页码 166-176出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2016.01.009
关键词
Chitosan; IL-17; Intestinal microbiota; mTOR
资金
- National Natural Science Foundation of China [31301985]
- China Postdoctoral Science Foundation [2014M562111, 2015T80871]
- Science and Technology Department of Hunan Province [2015RS4035]
- College Students Innovation Project of Hunan Agricultural University [XCX14039]
This study was conducted to explore the effect of chitosan supplementation on mouse intestinal microbiota and interleukin-17 (IL-17) expression. Chitosan supplementation reduced mouse body weight, associating with change of intestinal microbiota (i.e. lowering the ratio of Firmicutes: Bacteroidetes). In antibiotics treated mice, chitosan supplementation had little effect on mouse body weight. Chitosan supplementation decreased expression of IL-17 in mouse jejunum and inhibited the mTOR pathway. In antibiotics treated mice, chitosan also reduced expression of IL-17 in the jejunum. Activation of mTOR signalling in mouse increased expression of IL-17 in the jejunum in the context of chitosan supplementation. We conclude that chitosan supplementation reduces mouse body weight through the intestinal microbiota, and inhibits intestinal IL-17 expression through the mTOR signalling. The discovery of this study suggests the potentials of chitosan as a functional supplement in intestinal health. (C) 2016 Elsevier Ltd. All rights reserved.
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