Article
Biochemistry & Molecular Biology
Abdelaziz Ghanemi, Mayumi Yoshioka, Jonny St-Amand
Summary: SPARC is a protein expressed in various tissues, and its levels can increase in response to physiological and pathological changes such as injuries, exercise, regeneration, obesity, cancer, and inflammation. The interrelation between these changes and SPARC expression/secretion suggests it may serve as a biomarker with potential applications in mechanistic studies, animal model validation, disease prognosis, and drug evaluation.
Article
Biochemistry & Molecular Biology
Hye Jung Jang, Myung Geun Song, Cho Rong Park, Hyewon Youn, Yun-Sang Lee, Gi Jeong Cheon, Keon Wook Kang
Summary: Glioblastoma is a common and fatal primary glioma, but complete removal of brain tumor tissues is challenging for neurosurgeons. Fluorescence-guided surgery (FGS) and indocyanine green (ICG) are used to enhance visualization of tumor edges. The binding properties of ICG to human serum albumin (HSA) and the extracellular glycoprotein SPARC were studied. In vitro and in vivo studies showed that the uptake of ICG-HSA complex was higher in SPARC-expressing glioblastoma cells and tumors compared to free ICG. This suggests that ICG-HSA complex could be an efficient imaging agent for SPARC-expressing tumors, especially glioblastoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Abdelaziz Ghanemi, Aicha Melouane, Mayumi Yoshioka, Jonny St-Amand
Summary: The study found that Sparc KO mice exhibit an ageing-like phenotype, while SPARC overexpression and exercise provide similar benefits in counteracting ageing, helping to combat the ageing phenotype induced by SPARC deficiency and reversing age-related changes.
Article
Biology
Abdelaziz Ghanemi, Mayumi Yoshioka, Jonny St-Amand
Summary: SPARC protein plays a crucial role in tissue regeneration by creating an environment suitable for tissue regeneration and enhancing tissue repair ability, with potential applications in various diseases and bioengineering.
Article
Pharmacology & Pharmacy
Hiroe Toba, Mitsushi J. Ikemoto, Miyuki Kobara, Tetsuo Nakata
Summary: This study investigated the role of SPARC and ADAMTS1 in renal fibrosis using a rat model. The treatment with DOCA and salt induced kidney damage and fibrosis, and increased the expression of SPARC and ADAMTS1, promoting collagen deposition and fibrosis progression. The angiotensin II type-1 receptor blocker losartan suppressed the overexpression of SPARC and ADAMTS1, thereby slowing down fibrosis development.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Genetics & Heredity
Abdelaziz Ghanemi, Mayumi Yoshioka, Jonny St-Amand
Summary: Exercise has numerous benefits for health and is widely prescribed for various pathological conditions. Stimulating SPARC gene expression through exercise can be used for personalized medicine, optimizing exercise therapy by prescribing patterns corresponding to optimal SPARC/Sparc expression. Measuring exercise-dependent expression of Sparc could also enhance the selection of exercise animal models in research.
Article
Immunology
Gabriela Fonseca-Camarillo, Janette Furuzawa-Carballeda, Natalia Razo-Lopez, Rafael Barreto-Zuniga, Braulio Martinez-Benitez, Jesus K. Yamamoto-Furusho
Summary: The study showed an increase in gene and protein expression of SPARC in patients with active UC, with significant correlation to histological activity. The results suggest that SPARC could be a marker of intestinal inflammation in UC.
Article
Medicine, Research & Experimental
Yang Fu, Liying Luo, Ying Fan, Min Tang
Summary: The study showed that downregulation of SPARC in HTMCs reduced F-actin and ZO-1 expression levels, promoted phagocytosis, and may affect aqueous humor outflow through the trabecular meshwork pathway.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Genetics & Heredity
Abdelaziz Ghanemi, Mayumi Yoshioka, Jonny St-Amand
Summary: SPARC is proposed as a potential therapy for antiageing, as it can mimic the effects of exercise without the need for physical activity.
Article
Sport Sciences
Toshiaki Miyamoto, Yurika Shimizu, Yuka Matsuo, Taiki Otaru, Yuto Kanzawa, Nao Miyamae, Eri Yamada, Tomoyuki Katsuno
Summary: This study examined the effects of exercise intensity and duration on circulating SPARC levels, finding that high-intensity exercise (W60) significantly increased serum SPARC levels, with changes in SPARC levels correlating with lactate concentrations, skeletal muscle mass, and knee extensor muscle strength.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2022)
Article
Neurosciences
Donglin Zhou, Tao Li, Xianjun Tan, Chenping Yun, Peng Jiang, Tongfu Zhang, Hong Kuang, Yunyan Wang
Summary: SPARC regulates mitochondrial function in VSMC and induces apoptosis through HK2, which plays an important role in the formation and rupture of IA. Targeting SPARC may be a novel strategy to delay the development of intracranial aneurysms.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Cell Biology
Rongbin Ge, Jing Zhang, Min Lu, Yuchuan Shi, Shi Yan, Zixuan Xue, Zongwei Wang, Antonio Lopez-Beltran, Liang Cheng
Summary: Primary mucinous adenocarcinoma of the urethra is an extremely rare entity. This study characterized the clinicopathological, immunohistochemical and molecular features of 35 cases, providing crucial insights into its diagnosis, management and potential targeted treatments. The study identified a greater sensitivity to CDX2, SATB2 and CDH17 in these tumors for the first time, and identified characteristics such as an MSI-low profile, non-V600E BRAF mutations and an absence of ALK rearrangements.
Article
Endocrinology & Metabolism
Liying Luo, Xi Sun, Min Tang, Jiahui Wu, Tianwei Qian, Shimei Chen, Zhiyuan Guan, Yanyun Jiang, Yang Fu, Zhi Zheng
Summary: This study found that SPARC promotes diabetic retinopathy via the regulation of integrin beta 1. The results suggest that SPARC plays an important role in the development and progression of DR and may be a potential therapeutic target for its treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Chang Woo Kim, Jae Myung Cha, Min Seob Kwak
Summary: In colorectal cancer, patients with mucinous adenocarcinoma (MAC) have a poorer prognosis compared to those with traditional adenocarcinoma (TAC), especially in Stage II. The study findings suggest that identifying potential biomarkers and biological pathways can be useful in predicting the prognosis of colorectal cancer.
Review
Biochemistry & Molecular Biology
Catalina Atorrasagasti, Agostina M. Onorato, Guillermo Mazzolini
Summary: Secreted protein acidic and rich in cysteine (SPARC) is a crucial player in the development of obesity, diabetes, and fatty liver disease. It is involved in adipogenesis, cellular metabolism, extracellular matrix modulation, glucose, and lipid metabolism. SPARC may serve as a potential therapeutic target or biomarker for disease progression.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Meeting Abstract
Oncology
Yuji Nojima, Katsuhiko Shimizu, Ai Maeda, Shinsuke Saisho, Riki Okita, Masao Nakata
JOURNAL OF THORACIC ONCOLOGY
(2017)
Article
Oncology
Katsuhiko Shimizu, Riki Okita, Shinsuke Saisho, Ai Maeda, Yuji Nojima, Masao Nakata
ANTICANCER RESEARCH
(2018)
Editorial Material
Respiratory System
Riki Okita, Katsuhiko Shimizu, Masao Nakata
JOURNAL OF THORACIC DISEASE
(2018)
Article
Health Care Sciences & Services
Katsuhiko Shimizu, Riki Okita, Shinsuke Saisho, Ai Maeda, Yuji Nojima, Masao Nakata
THERAPEUTICS AND CLINICAL RISK MANAGEMENT
(2019)
Article
Oncology
Riki Okita, Ai Maeda, Katsuhiko Shimizu, Yuji Nojima, Shinsuke Saisho, Masao Nakata
Meeting Abstract
Oncology
K. Okabe, H. Inokawa, M. Hayashi, R. Okita, M. Furukawa
JOURNAL OF THORACIC ONCOLOGY
(2019)
Article
Oncology
Nobutaka Kawamoto, Riki Okita, Masataro Hayashi, Masashi Furukawa, Hidetoshi Inokawa, Kazunori Okabe
Article
Oncology
Nobutaka Kawamoto, Riki Okita, Hidetoshi Inokawa, Masataro Hayashi, Masashi Furukawa, Masanori Okada, Kazunori Okabe
Article
Oncology
Nobutaka Kawamoto, Masashi Furukawa, Riki Okita, Masanori Okada, Masataro Hayashi, Hidetoshi Inokawa, Kazunori Okabe, Keisuke Kawata
Article
Surgery
Nobutaka Kawamoto, Riki Okita, Hidetoshi Inokawa, Tomoyuki Murakami, Kazunori Okabe
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2020)
Meeting Abstract
Oncology
R. Okita, K. Shimizu, Y. Nojima, S. Saisho, M. Nakata
ANNALS OF ONCOLOGY
(2019)
Meeting Abstract
Oncology
K. Okabe, H. Inokawa, M. Hayashi, R. Okita, M. Furukawa, M. Yamamoto
JOURNAL OF THORACIC ONCOLOGY
(2018)
Meeting Abstract
Oncology
R. Okita, A. Maeda, K. Shimizu, Y. Nojima, S. Saisho, M. Nakata
JOURNAL OF THORACIC ONCOLOGY
(2017)
Article
Oncology
Riki Okita, Ai Maeda, Katsuhiko Shimizu, Yuji Nojima, Shinsuke Saisho, Masao Nakata
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2017)