Article
Genetics & Heredity
Siyuan Liu, Zhenghao Li, Huihuang Li, Xueyi Wen, Yu Wang, Qilin Chen, Xundi Xu
Summary: A TGF beta-associated signature has been developed and validated, which is capable of predicting the survival outcome and depicting the tumor microenvironment immune characteristics in gastric carcinoma (GC).
FRONTIERS IN GENETICS
(2022)
Article
Pharmacology & Pharmacy
Cheng Zeng, Rong He, Yuyang Dai, Xiaohuan Lu, Linghui Deng, Qi Zhu, Yu Liu, Qian Liu, Wenbin Lu, Yue Wang, Jianhua Jin
Summary: This study identified two distinct TGF-beta subgroups in gastric cancer and constructed a novel TGF-beta-associated prognostic model, indicating the risk score as an independent prognostic factor. Patients in the low-risk group showed better prognosis and higher response rate to immunotherapy. The risk score and sensitivity to anti-tumor drugs were strongly correlated.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xinying Jiang, Hailing Zhang, Hengshuo Zhang, Fan Wang, Xiaochang Wang, Tong Ding, Xuxiang Zhang, Ting Wang
Summary: This study revealed that MC-LR promotes CRC cell migration by upregulating TGF-beta 1 expression and secretion in M2 macrophages and downregulating CST3 in CRC cells. The mice in the MC-LR/AOM/DSS group showed more tumor nodules and deeper tumor invasion compared to the AOM/DSS group, indicating the importance of MC-LR in the tumor microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Jingjing Zhang, Jinxin Qiu, Wenyong Zhou, Jianping Cao, Xuefei Hu, Wenli Mi, Bing Su, Bin He, Ju Qiu, Lei Shen
Summary: This study identifies neuropilin-1 (Nrp1) as a tissue-specific marker of lung-resident ILC2s, which enhances their function and type 2 immune response by upregulating IL-33 receptor ST2 expression. Inhibition of Nrp1 suppresses IL-5 and IL-13 production by ILC2s and protects mice from the development of pulmonary fibrosis.
Article
Oncology
Zongxian Zhao, Shuliang Li, Shilong Li, Jun Wang, Hai Lin, Weihua Fu
Summary: The study revealed that upregulated expression of CDH6 in gastric cancer is associated with diagnosis and prognosis, making it a potential independent molecular biomarker.
CANCER CELL INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Aurora Gazzillo, Michela Anna Polidoro, Cristiana Soldani, Barbara Franceschini, Ana Lleo, Matteo Donadon
Summary: The liver is the most common site for colorectal cancer (CRC) metastasis, with colorectal liver metastasis (CLM) having a poor prognosis. Tumor-associated macrophages (TAMs) play a role in promoting epithelial-to-mesenchymal transition (EMT) through the TGF-beta signaling pathway, contributing to CLM development. However, the exact mechanism of the interaction between TAMs and EMT is still poorly understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Karim Rihawi, Angela Dalia Ricci, Alessandro Rizzo, Stefano Brocchi, Giovanni Marasco, Luigi Vincenzo Pastore, Fabiola Lorena Rojas Llimpe, Rita Golfieri, Matteo Renzulli
Summary: Gastric cancer is the fifth most commonly diagnosed cancer worldwide, with poor prognosis in advanced stage patients despite improvements in treatment. Research efforts have focused on identifying novel therapeutic targets, with the tumor microenvironment emerging as a potential target. Various agents and strategies targeting the TME are currently being evaluated in preclinical and clinical studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Han Wang, Junchang Zhang, Huan Li, Hong Yu, Songyao Chen, Shuhao Liu, Changhua Zhang, Yulong He
Summary: This study investigated the role of FN1 in the immune relationship with gastric cancer. The results showed that FN1 expression was higher in tumor tissue compared to neighboring tissue, and coexpression of FN1 with other genes was associated with poor prognosis. Additionally, increased FN1 expression was related to immune infiltration, particularly macrophage infiltration. Immunohistochemistry confirmed the connection between FN1 expression and M2 macrophages. Overall, this study suggests that FN1 can impact the immune microenvironment and serve as a prognostic marker in gastric cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Kunpeng Lv, Mengyao Sun, Hanji Fang, Jieti Wang, Chao Lin, Hao Liu, Heng Zhang, He Li, Hongyong He, Yun Gu, Ruochen Li, Fei Shao, Jiejie Xu
Summary: In gastric cancer, Siglec-10 positive tumor-associated macrophages (TAMs) contribute to immune evasion by exhibiting an immunosuppressive phenotype and hindering CD8+ T cell-mediated antitumor immune response. Blocking Siglec-10 can reinvigorate the antitumor immune response and synergistically enhance the efficacy of anti-PD-1 immunotherapy in an ex vivo gastric cancer tumor fragment platform.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Yawei Zhang, Han Wang, Xiaoyu Xu, Huifang Liu, Tengfei Hao, Songcheng Yin, Changhua Zhang, Yulong He
Summary: The expression of LILRB1 is associated with advanced tumor stage, higher recurrence risk, and worse survival in gastric cancer. LILRB1+ M2 TAMs play a crucial role in creating an immunosuppressive microenvironment and predicting poor prognosis. Therapeutic targeting of LILRB1+ M2 TAMs may be essential for improving the treatment outcomes in gastric cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yu Liu, Mingxu Da
Summary: This study found that WTAP is significantly overexpressed in gastric carcinoma tissue, and its high expression is closely associated with poor prognosis in gastric cancer patients. Overexpression of WTAP can promote migration and EMT of GC cells, as well as the expression of TGF-beta and mRNA stability. Knockdown of WTAP inhibits migration of GC cells, decreases TGF-beta expression, and reduces mRNA stability. In addition, WTAP also promotes multiple chemotherapy and radiotherapy resistance in GC.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Pharmacology & Pharmacy
Yonghui Zou, Yi Xu, Xiaofeng Chen, Yaoqi Wu, Longsheng Fu, Yanni Lv
Summary: LRG1 is an important protein involved in normal physiological activities of the nervous system and has been found to affect the development of various diseases. However, research on its role in disease is still in its early stages, and further studies are needed to uncover its potential therapeutic value.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Li Han, Huaiqing Luo, Wenjie Huang, Jiang Zhang, Di Wu, Jinmei Wang, Jiao Pi, Chi Liu, Xiangping Qu, Huijun Liu, Xiaoqun Qin, Yang Xiang
Summary: Persistent injury and improper repair in bronchial epithelial cells contribute to airway inflammation and remodeling in asthma. E-cadherin plays a role in regulating the balance between EMT and MET during injury repair by inhibiting EMT features, enhancing MET features, and decreasing TGF-beta 1 secretion and Snail expression, ultimately facilitating epithelial repair.
Article
Oncology
Li-Ren Jiang, Ning Zhang, Si-Teng Chen, Jin He, Yong-Hua Liu, Ya-Qin Han, Xiao-Qin Shi, Ji-Ji Yang, Dong-Yun Mu, Guo-Hui Fu, Feng Gao
Summary: PD-1-positive TAMs may serve as a negative survival indicator in MIBC patients, and their mechanistic effects could result from a combination of PD-1 and CD68 activity. High immune score and M2 TAMs are strongly associated with poor clinical outcomes in MIBC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Seon-Young Kim, Song-Yi Park, Hwan-Seok Jang, Yong-Doo Park, Sun-Ho Kee
Summary: Yes-associated protein (YAP) regulates cell migration by influencing ZO-1, potentially through the NF-kappa B signaling pathway. The association of YAP with ZO-1 via angiomotin (AMOT) at TJs at high expression levels helps maintain TJ integrity.
