The discovery and evaluation of diaryl ether heterocyclic sulfonamides as URAT1 inhibitors for the treatment of gout

The design, synthesis and evaluation of low molecular weight acidic sulfonamides as URAT1 inhibitors for the treatment of gout

(2016) Andy Pike et al.   MedChemComm

New medications in development for the treatment of hyperuricemia of gout

(2015) Cesar Diaz-Torné et al.   CURRENT OPINION IN RHEUMATOLOGY

Investigational drugs for hyperuricemia

(2015) Hania Shahid et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Pharmacokinetics, pharmacodynamics, and safety of lesinurad, a selective uric acid reabsorption inhibitor, in healthy adult males

(2015) Zancong Shen et al.   Drug Design Development and Therapy

Uricosuric drugs

(2014) Mary H. Bach et al.   CURRENT OPINION IN RHEUMATOLOGY

Inhibitory effects of p-aminohippurate and probenecid on the renal clearance of adefovir and benzylpenicillin as probe drugs for organic anion transporter (OAT) 1 and OAT3 in humans

(2014) Kazuya Maeda et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Emerging Therapies for Gout

(2014) N. Lawrence Edwards et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Hepatocellular toxicity of benzbromarone: Effects on mitochondrial function and structure

(2014) Andrea Felser et al.   TOXICOLOGY

New Therapies for Gout

(2013) Daria B. Crittenden et al.   Annual Review of Medicine

Functional cooperation of URAT1 (SLC22A12) and URATv1 (SLC2A9) in renal reabsorption of urate

(2013) Takeo Nakanishi et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The volume of distribution is an indicator of poorin vitro–in vivoextrapolation of clearance for acidic drugs in the rat

(2013) Anna-Karin Sohlenius-Sternbeck et al.   XENOBIOTICA

Functional Cooperation of SMCTs and URAT1 for Renal Reabsorption Transport of Urate

(2012) Yang Lu et al.   Drug Metabolism and Pharmacokinetics

Emerging therapies for gout

(2012) Jasvinder A Singh   EXPERT OPINION ON EMERGING DRUGS

Development of a new permeability assay using low‐efflux MDCKII cells

(2011) Li Di et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Benzbromarone Pharmacokinetics and Pharmacodynamics in Différent Cytochrome P450 2C9 Genotypes

(2010) Shinya Uchida et al.   Drug Metabolism and Pharmacokinetics

Effect of Fenofibrate on Uric Acid Metabolism and Urate Transporter 1

(2010) Daijiro Uetake et al.   INTERNAL MEDICINE

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

A Benefit-Risk Assessment of Benzbromarone in the Treatment of Gout

(2009) Ming-Han H Lee et al.   DRUG SAFETY