期刊
MEDCHEMCOMM
卷 7, 期 8, 页码 1664-1671出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6md00169f
关键词
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资金
- Natural Science Foundation of China [21372206, 81430085, 81273393]
- Development Foundation of Priority, Ministry of Education [20134101130001]
A series of 1,2,3-triazole-chalcone hybrids were designed, synthesized and evaluated for their anti-proliferative activity against three selected cancer cell lines (SK-N-SH, HepG-2 and MGC-803). Most of the synthesized compounds exhibited moderate to good activity against all the cancer cell lines selected. Particularly, compound 12k showed the most excellent antiproliferative activity with an IC50 value of 1.53 mu M against SK-N-SH cancer cells. The mechanism studies revealed that compound 12k inhibited the proliferation of SK-N-SH cancer cells by inducing apoptosis and arresting the cell cycle at the G1 phase.
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