期刊
BIOANALYSIS
卷 8, 期 6, 页码 557-573出版社
FUTURE SCI LTD
DOI: 10.4155/bio-2015-0004
关键词
complex mixture analysis; metabolite databases; metabolomics; MS of metabolite mixtures; nanoparticle; assisted metabolomics; NMR of metabolite mixtures; paramagnetic relaxation enhancement
资金
- NIH [R01 GM 066041]
- NIH (SECIM grant) [U24 DK097209-01A1]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [U24DK097209] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM066041] Funding Source: NIH RePORTER
This review discusses strategies for the identification of metabolites in complex biological mixtures, as encountered in metabolomics, which have emerged in the recent past. These include NMR database-assisted approaches for the identification of commonly known metabolites as well as novel combinations of NMR and MS analysis methods for the identification of unknown metabolites. The use of certain chemical additives to the NMR tube can permit identification of metabolites with specific physical chemical properties.
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