期刊
BIOANALYSIS
卷 8, 期 14, 页码 1509-1532出版社
FUTURE SCI LTD
DOI: 10.4155/bio-2016-0090
关键词
capillary electrophoresis; clinical metabolomics; data analysis; GC; LC; lipidomics; MS; NMR
资金
- Swiss National Science Foundation [P2GEP3_155633]
- Swiss National Science Foundation (SNF) [P2GEP3_155633] Funding Source: Swiss National Science Foundation (SNF)
Metabolomics-based strategies have become an integral part of modern clinical research, allowing for a better understanding of pathophysiological conditions and disease mechanisms, as well as providing innovative tools for more adequate diagnostic and prognosis approaches. Metabolomics is considered an essential tool in precision medicine, which aims for personalized prevention and tailor-made treatments. Nevertheless, multiple pitfalls may be encountered in clinical metabolomics during the entire workflow, hampering the quality of the data and, thus, the biological interpretation. This review describes the challenges underlying metabolomics-based experiments, discussing step by step the potential pitfalls of the analytical process, including study design, sample collection, storage, as well as preparation, chromatographic and electrophoretic separation, detection and data analysis. Moreover, it offers practical solutions and strategies to tackle these challenges, ensuring the generation of high-quality data.
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