期刊
BIOANALYSIS
卷 8, 期 18, 页码 1937-1949出版社
FUTURE SCI LTD
DOI: 10.4155/bio-2016-0112
关键词
high throughput; methionine pathway; one-carbon metabolism; red blood cells; UPLC-MS/MS
Aim: There is increasing interest in the profiling and quantitation of methionine pathway metabolites for health management research. Currently, several analytical approaches are required to cover metabolites and co-factors. Results: We report the development and the validation of a method for the simultaneous detection and quantitation of 13 metabolites in red blood cells. The method, validated in a cohort of healthy human volunteers, shows a high level of accuracy and reproducibility. Conclusion: This high-throughput protocol provides a robust coverage of central metabolites and co-factors in one single analysis and in a high-throughput fashion. In large-scale clinical settings, the use of such an approach will significantly advance the field of nutritional research in health and disease.
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