Failure of the Nemo Trial: Bumetanide Is a Promising Agent to Treat Many Brain Disorders but Not Newborn Seizures

Bumetanide to Treat Parkinson Disease

(2016) Philippe Damier et al.   CLINICAL NEUROPHARMACOLOGY

Treating Schizophrenia With the Diuretic Bumetanide

(2016) Eric Lemonnier et al.   CLINICAL NEUROPHARMACOLOGY

KCC2 rescues functional deficits in human neurons derived from patients with Rett syndrome

(2016) Xin Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Pilot Study on the Combination of Applied Behavior Analysis and Bumetanide Treatment for Children with Autism

(2015) Lin Du et al.   JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial

(2015) Ronit M Pressler et al.   LANCET NEUROLOGY

Paradoxical Benzodiazepine Response: A Rationale for Bumetanide in Neurodevelopmental Disorders?

(2015) H. Bruining et al.   PEDIATRICS

Plasma oxytocin levels predict social cue recognition in individuals with schizophrenia

(2015) Gregory P. Strauss et al.   SCHIZOPHRENIA RESEARCH

Diuretic Exposure in Premature Infants from 1997 to 2011

(2014) Kim Chantala et al.   AMERICAN JOURNAL OF PERINATOLOGY

Excitation/inhibition imbalance and impaired synaptic inhibition in hippocampal area CA3 ofMecp2knockout mice

(2014) Gaston Calfa et al.   HIPPOCAMPUS

The Developmental Switch in GABA Polarity Is Delayed in Fragile X Mice

(2014) Q. He et al.   JOURNAL OF NEUROSCIENCE

Early depolarizing GABA controls critical-period plasticity in the rat visual cortex

(2014) Gabriele Deidda et al.   NATURE NEUROSCIENCE

Cation-chloride cotransporters in neuronal development, plasticity and disease

(2014) Kai Kaila et al.   NATURE REVIEWS NEUROSCIENCE

Depolarizing chloride gradient in developing cochlear nucleus neurons: Underlying mechanism and implication for calcium signaling

(2014) M. Witte et al.   NEUROSCIENCE

The GABA excitatory/inhibitory developmental sequence: A personal journey

(2014) Y. Ben-Ari   NEUROSCIENCE

A Double-Blind Randomized Controlled Trial of Oxytocin Nasal Spray and Social Cognition Training for Young People With Early Psychosis

(2014) Cristina Cacciotti-Saija et al.   SCHIZOPHRENIA BULLETIN

Response to Comment on "Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring"

(2014) S. Eftekhari et al.   SCIENCE

Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism Pathogenesis in Rodent Offspring

(2014) R. Tyzio et al.   SCIENCE

Cortical GABAergic excitation contributes to epileptic activities around human glioma

(2014) J. Pallud et al.   Science Translational Medicine

Treating Fragile X syndrome with the diuretic bumetanide: a case report

(2013) Eric Lemonnier et al.   ACTA PAEDIATRICA

Concurrent Maturation of Inner Hair Cell Synaptic Ca2+ Influx and Auditory Nerve Spontaneous Activity around Hearing Onset in Mice

(2013) A. B. Wong et al.   JOURNAL OF NEUROSCIENCE

Chloride extrusion enhancers as novel therapeutics for neurological diseases

(2013) Martin Gagnon et al.   NATURE MEDICINE

Abnormal Expression of Cerebrospinal Fluid Cation Chloride Cotransporters in Patients with Rett Syndrome

(2013) Sofia Temudo Duarte et al.   PLoS One

Bumetanide reduces seizure frequency in patients with temporal lobe epilepsy

(2012) Sanaz Eftekhari et al.   EPILEPSIA

Subthalamic Lesion or Levodopa Treatment Rescues Giant GABAergic Currents of PINK1-Deficient Striatum

(2012) N. Dehorter et al.   JOURNAL OF NEUROSCIENCE

A randomised controlled trial of bumetanide in the treatment of autism in children

(2012) E Lemonnier et al.   Translational Psychiatry

Neuronal chloride accumulation and excitatory GABA underlie aggravation of neonatal epileptiform activities by phenobarbital

(2011) Romain Nardou et al.   BRAIN

Expression of GABA Signaling Molecules KCC2, NKCC1, and GAD1 in Cortical Development and Schizophrenia

(2011) T. M. Hyde et al.   JOURNAL OF NEUROSCIENCE

Alterations in the expression of neuronal chloride transporters may contribute to schizophrenia

(2011) Hans O. Kalkman   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Newborn Analgesia Mediated by Oxytocin during Delivery

(2011) Michel Mazzuca et al.   Frontiers in Cellular Neuroscience

Alterations of GABAergic Signaling in Autism Spectrum Disorders

(2011) Rocco Pizzarelli et al.   NEURAL PLASTICITY

Altered Expression of Regulators of the Cortical Chloride Transporters NKCC1 and KCC2 in Schizophrenia

(2010) Dominique Arion et al.   ARCHIVES OF GENERAL PSYCHIATRY

Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury

(2010) Pascale Boulenguez et al.   NATURE MEDICINE

Inhibitory actions of the gamma-aminobutyric acid in pediatric Sturge-Weber syndrome

(2009) Roman Tyzio et al.   ANNALS OF NEUROLOGY

Nkcc1 (Slc12a2) is required for the regulation of endolymph volume in the otic vesicle and swim bladder volume in the zebrafish larva

(2009) L. Abbas et al.   DEVELOPMENT

Bumetanide, an NKCC1 Antagonist, Does Not Prevent Formation of Epileptogenic Focus but Blocks Epileptic Focus Seizures in Immature Rat Hippocampus

(2009) Romain Nardou et al.   JOURNAL OF NEUROPHYSIOLOGY

Dopamine-Deprived Striatal GABAergic Interneurons Burst and Generate Repetitive Gigantic IPSCs in Medium Spiny Neurons

(2009) N. Dehorter et al.   JOURNAL OF NEUROSCIENCE

Bumetanide enhances phenobarbital efficacy in a neonatal seizure model

(2007) Volodymyr I. Dzhala et al.   ANNALS OF NEUROLOGY

Oxytocin Increases Gaze to the Eye Region of Human Faces

(2007) Adam J. Guastella et al.   BIOLOGICAL PSYCHIATRY