Article
Medicine, General & Internal
Ha-Jin Lim, Seung-Yeob Lee, Hyun-Jung Choi
Summary: The accuracy of ABL90 FLEX PLUS in measuring creatinine and blood urea nitrogen was evaluated, and suitable candidate specimens were identified. The results showed that ABL90 FLEX PLUS had mean differences of -0.10 and -3.51 mg/dL for creatinine and blood urea nitrogen, respectively, compared to other analyzers. Serum was found to be suitable for creatinine testing using ABL90 FLEX PLUS, while citrated whole-blood did not meet the acceptance criteria.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Transplantation
Solene M. Laville, Aymeric Couturier, Oriane Lambert, Marie Metzger, Nicolas Mansencal, Christian Jacquelinet, Maurice Laville, Luc Frimat, Denis Fouque, Christian Combe, Bruce M. Robinson, Benedicte Stengel, Sophie Liabeuf, Ziad A. Massy
Summary: This study aimed to determine the association between serum urea levels and adverse cardiovascular events and death in patients with chronic kidney disease (CKD) before renal replacement therapy (RRT). The study found that elevated serum urea levels were associated with increased risk of atheromatous and non-atheromatous cardiovascular events, as well as higher mortality rates.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Peripheral Vascular Disease
Xianghui Zeng, Qingfeng Zeng, Lanqian Zhou, Hengqing Zhu, Jianping Luo
Summary: The study found that the prevalence of chronic kidney disease, albuminuria, and macroalbuminuria among US adults with hypertension remained relatively stable from 1999 to 2018, but there was an increasing trend in stage 1 CKD.
Article
Pharmacology & Pharmacy
Boyue Huang, Zhizhen Huang, Hongkai Wang, Guoqi Zhu, Hui Liao, Zhiwen Wang, Baoxue Yang, Jianhua Ran
Summary: Urea plays an important role in anxiety related to chronic kidney disease by regulating compensatory proliferation of oligodendrocyte progenitor cells and changing myelin-related signaling pathways.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pediatrics
Ying Tang, Ling Hou, Tingting Sun, Shanping Li, Junli Cheng, Dan Xue, Xiuli Wang, Yue Du
Summary: Equations for estimating glomerular filtration rate (GFR) in Chinese children with chronic kidney disease (CKD) were developed based on serum creatinine, blood urea nitrogen (BUN), and cystatin C. These equations were found to be more accurate than commonly used equations in this population.
PEDIATRIC NEPHROLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Devika S. Pillai, Subhas G. Babu, Renita Castelino, Sajad Ahmad Buch
Summary: This study aimed to estimate, compare, and correlate serum and salivary creatinine and urea levels in healthy subjects and subjects with CKD. The results showed that the levels of serum and salivary creatinine and urea were significantly increased in subjects with CKD compared to healthy subjects. Therefore, saliva testing of creatinine and urea levels has potential value in the diagnosis of CKD.
JOURNAL OF INDIAN ACADEMY OF ORAL MEDICINE AND RADIOLOGY
(2023)
Review
Urology & Nephrology
Manal Beshay, Connie M. Rhee, Kamyar Kalantar-Zadeh
Summary: Serum creatinine, urea, and cystatin C are commonly used biomarkers for estimating kidney function, but traditional laboratory-based testing methods limit frequent monitoring and patient self-management. Recent studies have shown that noninvasive salivary and fingerstick blood assessments can enable frequent monitoring of kidney function outside of clinical settings. A practical, cost-effective, and minimally invasive multimarker assessment platform could address the unmet needs in the management of CKD patients.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2022)
Article
Medicine, General & Internal
Suk Hyung Choe, Hyeyeon Cho, Jinyoung Bae, Sang-Hwan Ji, Hyun-Kyu Yoon, Ho-Jin Lee, Ji-Hyun Lee, Jin-Tae Kim, Won Ho Kim
Summary: The study aimed to evaluate the association between the duration and stage of acute kidney injury (AKI) and the occurrence of chronic kidney disease (CKD) in patients undergoing cardiac or thoracic aortic surgery. Results showed a significant and graded association between AKI stages and the development of new-onset CKD during three years after surgery, with higher duration and severity of AKI providing stronger predictive value for CKD development.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Transplantation
Amy Y. M. Au, Kevin Mantik, Forough Bahadory, Paul Stathakis, Hayley Guiney, Jonathan Erlich, Robert Walker, Richie Poulton, Andrea Rita Horvath, Zoltan H. Endre
Summary: Elevated plasma methylarginine concentrations are associated with chronic kidney disease (CKD) and cardiovascular disease. A cohort at high risk of poor kidney health outcomes was identified using plasma cystatin C-based estimated glomerular filtration rate trajectories. Methylarginine metabolites were measured in plasma samples from the cohort, and the concentrations were found to facilitate risk stratification for CKD progression.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Parasitology
Maria Alfonsa Cavalera, Floriana Gernone, Annamaria Uva, Rossella Donghia, Claudia Zizzadoro, Andrea Zatelli
Summary: This study assessed the efficacy of domperidone plus renal diet in slowing the progression of nephropathy in leishmaniotic dogs with CKD, evaluating sSDMA and sCr as markers of kidney function.
PARASITES & VECTORS
(2022)
Article
Urology & Nephrology
Thorir Einarsson Long, Dadi Helgason, Solveig Helgadottir, Gisli Heimir Sigurdsson, Runolfur Palsson, Martin Ingi Sigurdsson, Olafur Skuli Indridason
Summary: Mild Stage 1 AKI is associated with development and progression of CKD, but not with inferior 1-year survival. These findings support the inclusion of a small absolute increase in SCr in the definition of AKI.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Urology & Nephrology
Donghai Wen, Linda Zhou, Zihe Zheng, Aditya Surapaneni, Christie M. Ballantyne, Ron C. Hoogeveen, Michael G. Shlipak, Sushrut S. Waikar, Ramachandran S. Vasan, Paul L. Kimmel, Ruth F. Dubin, Rajat Deo, Harold I. Feldman, Peter Ganz, Josef Coresh, Morgan E. Grams, Eugene P. Rhee
Summary: Testican-2, a protein released into circulation by the kidneys, is positively correlated with eGFR and eGFR slope. However, it is unknown whether higher testican-2 levels are associated with lower risk of ESKD.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Immunology
Julita Szulimowska, Anna Zalewska, Katarzyna Taranta-Janusz, Grazyna Marczuk-Kolada, Malgorzata Zendzian-Piotrowska, Mateusz Maciejczyk
Summary: Chronic kidney disease (CKD) is a systemic inflammatory disease that affects multiple organs, including the kidneys, cardiovascular system, and oral cavity. Children with CKD experience reduced saliva secretion (hyposalivation), leading to increased dental caries and impaired quality of life. This study evaluated the inflammatory and anti-inflammatory profile in the saliva of CKD children at different stages of renal failure. The results showed significant changes in salivary cytokines, chemokines, and growth factors in CKD children compared to healthy controls.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Daniel Edmonston, Tamara Isakova, Myles Wolf
Summary: In a large chronic kidney disease cohort, plasma serotonin levels correlated with blood pressure, and elevated serotonin levels were associated with left ventricular hypertrophy. In contrast, undetectable plasma serotonin was associated with the highest risk of heart failure and ASCVD events.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Karthik Krishna Munagala, Samarpita Nanda, Zoya Chowdhary, Lumbini Pathivada, Gopinath Vivekanandan, Sonika Bodhi
Summary: This study evaluated and compared the prevalence of periodontal disease among individuals with chronic kidney disease undergoing hemodialysis with healthy individuals, and found that renal disease may influence the progression of periodontal disease. It also suggested that patients with renal disease must be screened for periodontal disease.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)