期刊
JOURNAL OF GERIATRIC ONCOLOGY
卷 7, 期 4, 页码 270-280出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jgo.2016.04.008
关键词
Chemotherapy; Cancer treatment; Cognitive impairment; Older patients; Research gaps
资金
- NCI NIH HHS [P30 CA008748, UG1 CA189961, R25 CA102618, K07 CA168886, UG1 CA189823, DP2 CA195765] Funding Source: Medline
- NIA NIH HHS [T32 AG000212, U13 AG038151] Funding Source: Medline
Chemotherapy-related cognitive impairment (CRCI) can occur during or after chemotherapy and represents a concern for many patients with cancer. Among older patients with cancer, in whom there is little clinical trial evidence examining side effects like CRCI, many unanswered questions remain regarding risk for and resulting adverse outcomes from CRCI. Given the rising incidence of cancer with age, CRCI is of particular concern for older patients with cancer who receive treatment. Therefore, research related to CRCI in older patients with cancers is a high priority. In this manuscript, we discuss current gaps in research highlighting the lack of clinical studies of CRCI in older adults, the complex mechanisms of CRCI, and the challenges in measuring cognitive impairment in older patients with cancer. Although we focus on CRCI, we also discuss cognitive impairment related to cancer itself and other treatment modalities. We highlight several research priorities to improve the study of CRCI in older patients with cancer. (C) 2016 Elsevier Ltd. All rights reserved.
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