期刊
CHEMICAL SCIENCE
卷 7, 期 2, 页码 1057-1062出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5sc03175c
关键词
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资金
- MEXT (Japan)
- JSPS
- Grants-in-Aid for Scientific Research [16H01687, 25810057] Funding Source: KAKEN
An enantioselective Friedel-Crafts reaction with aliphatic ketimines generated in situ from hemiaminal ethers catalyzed by a chiral Bronsted acid was investigated. The reaction of 2-methoxyfuran with (thio) hydantoin-derived hemiaminal methyl ether proceeded under the influence of a chiral phosphoric acid catalyst to afford the corresponding adduct possessing a quaternary stereogenic center in high yield with high enantioselectivity. Theoretical studies were also conducted to clarify the mechanism of the stereochemical outcome and the major factors contributing to the efficient enantioselection.
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