期刊
ARTHRITIS CARE & RESEARCH
卷 68, 期 10, 页码 1560-1566出版社
WILEY
DOI: 10.1002/acr.22866
关键词
-
类别
资金
- NIH [N01-AR-2-2258, N01-AR-2-2259, N01-AR-22260, N01-AR-2-2261, N01-AR-2-2262]
- Bioiberica (Barcelona, Spain)
- Osteoarthritis Research Unit
- Chair in Osteoarthritis of the University of Montreal (Montreal, Quebec, Canada)
- ArthroLab, Inc.
- Bioiberica
Objective. To examine the long-term (6-year) effect of combined glucosamine (Glu) and chondroitin sulfate (CS) treatment on cartilage volume in knee osteoarthritis (OA). Methods. Participants were from the Osteoarthritis Initiative progression and incidence subcohorts, had magnetic resonance imaging (MRI) of the target knee at baseline and 6 years, joint space width >1 mm, and data available on Glu/CS consumption (n=1,593). They were stratified into 2 main groups based on whether or not they had medial meniscal extrusion at baseline. The group with meniscal extrusion (n=429) was further stratified into subgroups based on exposure or no exposure to Glu/CS as follows: not exposed, 1 year, 2-3 years, and 4-6 years. Cartilage volume was assessed using fully automated quantitative MRI technology. Results. The Jonckheere-Terpstra trend test indicated that treatment with Glu/CS significantly reduced the cartilage volume loss in the global knee, associated with the lateral compartment. Multivariate analysis further demonstrated that the extent of the treatment's positive effect was related to exposure time to treatment, the protective effect at 6 years being significant in participants exposed to >= 2 years of treatment. Conclusion. These findings provide future support for the long-term protective structure-modifying effects of Glu/CS treatment in knee OA subjects.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据