Article
Microbiology
Yana Igolkina, Valeriy Yakimenko, Artem Tikunov, Tamara Epikhina, Aleksey Tancev, Nina Tikunova, Vera Rar
Summary: The prevalence and genetic diversity of Rickettsia spp. were investigated in Ixodes apronophorus, Ixodes persulcatus, and Ixodes trianguliceps ticks from the same habitats in Western Siberia. Rickettsia helvetica was found in I. apronophorus, while Candidatus Rickettsia tarasevichiae dominated in I. persulcatus and I. trianguliceps were infected with Candidatus Rickettsia uralica, R. helvetica, and Ca. R. tarasevichiae. Phylogenetic analysis revealed the high genetic variability of R. helvetica.
Article
Infectious Diseases
Yana Igolkina, Aleksey Nikitin, Yulia Verzhutskaya, Natalia Gordeyko, Artem Tikunov, Tamara Epikhina, Nina Tikunova, Vera Rar
Summary: The discovery of Candidatus Rickettsia mendelii in 2016 in the Asian region has significant implications for the phylogeny of basal groups in Rickettsia spp.
TICKS AND TICK-BORNE DISEASES
(2023)
Article
Infectious Diseases
Yana Igolkina, Vera Rar, Valeriy Yakimenko, Artem Tikunov, Nina Tikunova
Summary: A new candidate species of the spotted fever group, Candidatus Rickettsia thierseensis, was found in Austria and its gene sequences were highly similar to Candidatus Rickettsia uralica identified in Russia. Comparative sequence analysis confirmed that Candidatus R. uralica and Candidatus R. thierseensis are likely the same species.
TICKS AND TICK-BORNE DISEASES
(2022)
Article
Immunology
Yong Qi, Lele Ai, Jun Jiao, Junhu Wang, Deping Wu, Pengcheng Wang, Guoyu Zhang, Yong Qin, Cheng Hu, Ruichen Lv, Nianhong Lu, Changqiang Zhu, Yingqing Mao, Rui Qi, Yuexi Li, Weilong Tan
Summary: This study provides important epidemiological data on the prevalence of SFGR in ticks in Jiangsu province, Eastern China. The identification and characterization of Candidatus R. principis and Candidatus R. jingxinensis emphasize the need for attention and prevention of SFGR.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Yana Igolkina, Vera Rar, Elena Krasnova, Eugenia Filimonova, Artem Tikunov, Tamara Epikhina, Nina Tikunova
Summary: This study aimed to determine the etiologic agents of tick-borne rickettsioses in Western Siberia during three epidemiological seasons. The findings showed that Rickettsia raoultii is a common agent of tick-borne rickettsioses in Novosibirsk Province, and DNA from Rickettsia aeschlimannii and Rickettsia slovaca was found in clinical samples of patients in the Russian Federation for the first time.
TICKS AND TICK-BORNE DISEASES
(2022)
Article
Entomology
Changqiang Zhu, Lele Ai, Yong Qi, Yunsheng Liu, Hong Li, Fuqiang Ye, Qiuwei Wang, Yizhe Luo, Weilong Tan, Chunmeng Shi
Summary: Tick-borne diseases are widespread in hedgehogs and ticks in Southeast China, and the study provides evidence that hedgehogs may be involved in the natural transmission cycle of Rickettsia species.
EXPERIMENTAL AND APPLIED ACAROLOGY
(2022)
Article
Microbiology
Lucyna Kirczuk, Mariusz Piotrowski, Anna Rymaszewska
Summary: Tick-borne pathogens monitoring is a significant issue in global medical and veterinary fields. This study used PCR technique to detect pathogens in Ixodes ricinus ticks in Northwest Poland, finding DNA of Rickettsia spp. and A. phagocytophilum, with R. helvetica as the only species of Rickettsia present.
Article
Immunology
Maozhang He, Lifeng Zhang, Haoran Hu, Xiaohan Liu, Cong Zhang, Yu Xin, Boyu Liu, Zhen Chen, Kehan Xu, Yan Liu
Summary: In this study, a new strain of R. heilongjiangensis was isolated from a patient bitten by a Haemaphysalis longicornis tick in China. Comparative genomics analysis revealed unique genes associated with the pathogenicity of this strain. The findings suggest that this strain may represent a previously undescribed human-pathogenic lineage between R. heilongjiangensis and R. japonica.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Biology
Yuliya M. Didyk, Barbara Mangova, Eva Spitalska, Marketa Derdakova
Summary: Ticks in urban parks and green areas in Ukraine were found to carry Rickettsia spp. DNA, with 16.3% of I. ricinus and 29.1% of D. reticulatus testing positive. R. helvetica and R. monacensis were found in I. ricinus, while R. raoultii was found in D. reticulatus. This indicates a risk of rickettsiosis in popular tourist urban habitats in Ukraine.
Article
Microbiology
Neda Baseri, Mostafa Salehi-Vaziri, Ehsan Mostafavi, Fahimeh Bagheri Amiri, Mina Latifian, John Stenos, Saber Esmaeili
Summary: This study investigated the prevalence of Rickettsia conorii among suspected Crimean-Congo hemorrhagic fever patients in Iran. The results showed that Rickettsia conorii is indeed present in Iran and can be misdiagnosed with other febrile syndromes.
Article
Biochemistry & Molecular Biology
Miao Lu, Chao Meng, Bing Zhang, Xiao Wang, Junhua Tian, Guangpeng Tang, Wen Wang, Na Li, Mengyao Li, Xiaoyu Xu, Yue Sun, Chengyu Duan, Xincheng Qin, Kun Li
Summary: In this study, ticks collected from Guizhou Province, China were screened for Rickettsiales bacteria. Two spotted fever group Rickettsia species and one Candidatus Lariskella species were identified. These findings are important for understanding the bacteria and areas in China that have not been investigated.
Letter
Immunology
Thallitha S. W. J. Vieira, Flavia C. M. Collere, Larissa D. R. Ferrari, Rafael A. Baggio, Rogerio R. Lange, Marcos V. Ferrari, Juan C. M. Duque, Gustavo S. Sanches, Nathalia A. Pereira, Daniel M. Aguiar, Marcelo B. Labruna, Rafael F. C. Vieira
Summary: In this study, a novel species of Ehrlichia and Anaplasma were identified from tick-infested capybaras in southern Brazil. The tick vectors responsible for the transmission of these pathogens remain unknown.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Parasitology
Zheng Gui, Hao Cai, Dong-Dong Qi, Shun Zhang, Shao-Yin Fu, Jing-Feng Yu, Xiao-Yan Si, Ting Cai, Rui Mao
Summary: This study reveals the genetic diversity and population structure of Rickettsia in D. nuttalli in Inner Mongolia, and identifies two different species. The results show that Rickettsia has high genetic disparity and can adapt to different environments. There is low genetic differentiation between populations and no geographically differentiated structure.
PARASITES & VECTORS
(2022)
Article
Microbiology
Shehla Shehla, Farman Ullah, Abdulaziz Alouffi, Mashal M. Almutairi, Zaibullah Khan, Tetsuya Tanaka, Marcelo B. Labruna, Kun-Hsien Tsai, Abid Ali
Summary: This study investigated the tick species infesting livestock in Pakistan and the presence of Rickettsia spp. The results showed the distribution of Rickettsia species in ticks and identified certain species that can cause zoonotic diseases.
Article
Public, Environmental & Occupational Health
Pavle Banovic, Adrian Alberto Diaz-Sanchez, Clemence Galon, Angelique Foucault-Simonin, Verica Simin, Dragana Mijatovic, Luka Papic, Alejandra Wu-Chuang, Dasiel Obregon, Sara Moutailler, Alejandro Cabezas-Cruz
Summary: A study in a rural household in northern Serbia using a One Health approach found no evidence of Tick-borne pathogens (TBPs) infection in family members, despite the detection of pathogens in dogs and one goat. The most common pathogen detected in ticks was Rickettsia helvetica, while Anaplasma phagocytophilum and Rickettsia monacensis were frequent in dogs. Although Borrelia sp. was not detected in tested samples, a family member with a history of Lyme disease was seropositive for Borrelia burgdorferi sensu lato (s.l.).
Article
Virology
Vera Morozova, Mikhail Fofanov, Nina Tikunova, Igor Babkin, Vitaliy V. Morozov, Artem Tikunov
Article
Virology
Vera Morozova, Ghadeer Jdeed, Yuliya Kozlova, Igor Babkin, Artem Tikunov, Nina Tikunova
Summary: A novel Enterobacter cloacae phage, EC151, has been isolated and characterized, showing a siphovirus-like virion morphology. The EC151 genome is 60,753 bp in size, containing 58 putative genes, with limited similarity to other phage genomes in the NCBI GenBank database. Comparative proteomic phylogenetic analysis places EC151 in a distinct branch within a group of sequences sharing clades with Seuratvirus, Nonagvirus, and Vidquintavirus genera.
Article
Virology
Anton Chechushkov, Yuliya Kozlova, Ivan Baykov, Vera Morozova, Bogdana Kravchuk, Tatyana Ushakova, Alevtina Bardasheva, Ekaterina Zelentsova, Lina Al Allaf, Artem Tikunov, Valentin Vlassov, Nina Tikunova
Summary: Bacteriophages can affect the immune system of mice, with pre-existing antibodies against certain phages in mice before immunization. After immunization, levels of anti-phage antibodies increase and mouse serum demonstrates neutralizing properties against specific phage morphotypes.
Article
Infectious Diseases
Yana Igolkina, Vera Rar, Elena Krasnova, Eugenia Filimonova, Artem Tikunov, Tamara Epikhina, Nina Tikunova
Summary: This study aimed to determine the etiologic agents of tick-borne rickettsioses in Western Siberia during three epidemiological seasons. The findings showed that Rickettsia raoultii is a common agent of tick-borne rickettsioses in Novosibirsk Province, and DNA from Rickettsia aeschlimannii and Rickettsia slovaca was found in clinical samples of patients in the Russian Federation for the first time.
TICKS AND TICK-BORNE DISEASES
(2022)
Article
Microbiology
Alevtina Bardasheva, Artem Tikunov, Yuliya Kozlova, Elena Zhirakovskaia, Valeriya Fedorets, Natalya Fomenko, Tatyana Kalymbetova, Svetlana Chretien, Vitaliy Pavlov, Nina Tikunova, Vera Morozova
Summary: A study in Novosibirsk, Siberian Russia, characterized 394 strains of staphylococci from humans and pets in terms of antibiotic resistance and genes, revealing some sensitive isolates but prevalent methicillin-resistant and multidrug-resistant strains across all major species. Specific genes associated with resistance were identified, indicating a complex pattern of multidrug resistance, with additional antibiotic resistance genes found in MDR strains. Additionally, biofilm-producing abilities and genes related to virulence and pathogenicity were more prominent in MDR S. epidermidis compared to S. haemolyticus.
Article
Agriculture, Multidisciplinary
A. Y. Tikunov, A. N. Shvalov, V. V. Morozov, I. Babkin, G. Seledtsova, I. O. Voloshina, I. P. Ivanova, A. Bardasheva, V. V. Morozova, V. V. Vlasov, N. Tikunova
Summary: The study compared the biodiversity of the gut microbiota in patients with IBS, UC, and BA with that of healthy volunteers. Dysbiosis was found in patient samples, with a decrease in the Firmicutes/Bacteroidetes ratio in IBS and UC samples, and an increase in Proteobacteria sequences in all patient samples.
VAVILOVSKII ZHURNAL GENETIKI I SELEKTSII
(2021)
Article
Infectious Diseases
Yana Igolkina, Vera Rar, Valeriy Yakimenko, Artem Tikunov, Nina Tikunova
Summary: A new candidate species of the spotted fever group, Candidatus Rickettsia thierseensis, was found in Austria and its gene sequences were highly similar to Candidatus Rickettsia uralica identified in Russia. Comparative sequence analysis confirmed that Candidatus R. uralica and Candidatus R. thierseensis are likely the same species.
TICKS AND TICK-BORNE DISEASES
(2022)
Article
Virology
Vera Morozova, Yuliya Kozlova, Ghadeer Jdeed, Artem Tikunov, Tatyana Ushakova, Alevtina Bardasheva, Elena Zhirakovskaia, Yuliya Poletaeva, Elena Ryabchikova, Nina V. Tikunova
Summary: Aeromonas popoffii is an environmental species that can cause urinary tract infections. The discovery of the A. popoffii bacteriophage AerP_220 in river water suggests a potential new species within the Autographiviridae family.
Article
Virology
Andrey Matveev, Yana Khlusevich, Irina Kozlova, Leonid Matveev, Lyudmila Emelyanova, Artem Tikunov, Ivan Baykov, Nina Tikunova
Summary: In this study, a new protective antibody FVN-32 against tick-borne encephalitis virus was discovered. The antibody showed 37.5% protective efficacy in a mouse model, and its epitope was localized in the glycoprotein E domain I+II.
Article
Infectious Diseases
Yana Igolkina, Aleksey Nikitin, Yulia Verzhutskaya, Natalia Gordeyko, Artem Tikunov, Tamara Epikhina, Nina Tikunova, Vera Rar
Summary: The discovery of Candidatus Rickettsia mendelii in 2016 in the Asian region has significant implications for the phylogeny of basal groups in Rickettsia spp.
TICKS AND TICK-BORNE DISEASES
(2023)
Article
Microbiology
Vera Morozova, Yuliya Kozlova, Artem Tikunov, Igor Babkin, Tatyana Ushakova, Alevtina Bardasheva, Ghadeer Jdeed, Elena Zhirakovskaya, Alina Mogileva, Sergei Netesov, Nina Tikunova
Summary: Two novel P. protegens bacteriophages, PseuP_222 and Pseu_224, were isolated along with their host P. protegens CEMTC 4060 from the Inya river in Siberia. These phages have a siphovirus morphology and belong to lambdoid phages. Comparative genome analysis revealed their low similarity to other lambdoid phages and indicated that they belong to a genetically diverse group of phages of environmental Pseudomonas spp. The substantial divergences in their genomes and proteomes suggest that these phages have evolved independently and have recently started using the same host.
Article
Microbiology
Yana Igolkina, Valeriy Yakimenko, Artem Tikunov, Tamara Epikhina, Aleksey Tancev, Nina Tikunova, Vera Rar
Summary: The prevalence and genetic diversity of Rickettsia spp. were investigated in Ixodes apronophorus, Ixodes persulcatus, and Ixodes trianguliceps ticks from the same habitats in Western Siberia. Rickettsia helvetica was found in I. apronophorus, while Candidatus Rickettsia tarasevichiae dominated in I. persulcatus and I. trianguliceps were infected with Candidatus Rickettsia uralica, R. helvetica, and Ca. R. tarasevichiae. Phylogenetic analysis revealed the high genetic variability of R. helvetica.
Article
Biochemistry & Molecular Biology
Andrey Matveev, Oleg Pyankov, Yana Khlusevich, Olga Tyazhelkova, Lyudmila Emelyanova, Anna Timofeeva, Andrey Shipovalov, Anton Chechushkov, Natalia Zaitseva, Gleb Kudrov, Gaukhar Yusubalieva, Saule Yussubaliyeva, Oxana Zhukova, Vladimir Baklaushev, Sergey Sedykh, Galina Lifshits, Artem Tikunov, Nina Tikunova
Summary: This study identified the first monoclonal antibody (mAb) that can cause antibody-dependent enhancement (ADE) in a SARS-CoV-2 in vivo model. The mAb RS2 showed high affinity for SARS-CoV-2 and demonstrated neutralizing ability in vitro. It was also found that severe COVID-19 patients had antibodies competing with mAb RS2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Igor Babkin, Artem Tikunov, Vera Morozova, Andrey Matveev, Vitaliy V. Morozov, Nina Tikunova
Summary: In this study, a unique phage genome was discovered during the analysis of the human gut virome. Comparative analysis identified two similar phage genomes, indicating the presence of a new species within the proposed Phassvirus genus. Furthermore, a group of divergent phage genomes including the proposed Phassvirus genus was identified in metagenome data. These findings highlight the importance of using different translation tables when depositing phage genomes in GenBank.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Vera Morozova, Igor Babkin, Yuliya Kozlova, Artem Tikunov, Tatiana Ushakova, Alevtina Bardasheva, Valeria Fedorets, Elena Zhirakovskaya, Nina Tikunova
Summary: Aeromonas salmonicida is a causative agent of septicemia in fish, leading to significant economic losses in the aquaculture industry. The emergence of antibiotic resistance requires the development of alternative treatment methods, such as phage therapy. In this study, a novel A. salmonicida jumbo phage, AerS_266, was isolated and characterized. It specifically infects mesophilic A. salmonicida strains and has a slow lytic life cycle. The phage's genome contains 253 putative genes, including genes encoding two multisubunit RNA polymerases, chimallin and PhuZ, making it a phiKZ-like phage. This is the first phiKZ-like phage found to infect A. salmonicida, although similar phages have been described for other Aeromonas species.
Article
Infectious Diseases
Harold Salant, Yaarit Nachum-Biala, Doni Zivotofsky, Tsachi Even Tzur, Gad Baneth
Summary: This study describes the presentation, clinical signs, parasitemia levels, laboratory findings and treatment of dogs infected with B. negevi. Treatment with imidocarb dipropionate was helpful for recovery from clinical disease but did not facilitate parasite elimination, and it is therefore recommended to treat canine B. negevi infection with the combination of atovaquone and azithromycin.
TICKS AND TICK-BORNE DISEASES
(2024)
Article
Infectious Diseases
Gervillien Arnold Malonga, Almoustapha Issiaka Maiga, Dimitry Moudiongui Mboungou Malanda, Mahamadou Saliou, Juth ece Private Malanda-Kiminou, Oumar Dolo, Anicet Luc Magloire Boumba, Alhassane Ba, Robert Murphy, Jean Felix Peko, Anne-Genevieve Marcelin, Vincent Calvez, Stephane Marot
Summary: A serological survey in sub-urban areas of the capital cities of Congo and Mali reveals human contact with Crimean-Congo hemorrhagic fever virus (CCHFV) associated with previously described CCHFV risk factors.
TICKS AND TICK-BORNE DISEASES
(2024)
Article
Infectious Diseases
Aleksander Wymazal, Sabina Nowak, Robert W. Myslajek, Anna Bajer, Renata Welc-Faleciak, Maciej Szewczyk, Iga Kwiatkowska, Kinga M. Stepniak, Michal Figura, Agnieszka Kloch
Summary: The wolf population in Central and Eastern Europe has been increasing, but their frequent contacts with humans make them a potential zoonotic reservoir. This study found a high prevalence of tick-borne pathogens in free-ranging wolves from Poland.
TICKS AND TICK-BORNE DISEASES
(2024)
Article
Infectious Diseases
Nannet D. Fabri, Hans Heesterbeek, Joris P. G. M. Cromsigt, Frauke Ecke, Hein Sprong, Lonneke Nijhuis, Tim R. Hofmeester, Nienke Hartemink
Summary: In many parts of the northern hemisphere, different species of deer, small mammals, and birds coexist and their composition can strongly influence the outbreak potential of tick-borne pathogens. This study investigates how the abundance and composition of vertebrate communities affect the basic reproduction number R0 of tick-borne pathogens, and shows that species composition plays a substantial role in the outbreak potential of tick-borne diseases.
TICKS AND TICK-BORNE DISEASES
(2024)
Article
Infectious Diseases
Lynn M. Osikowicz, Maria R. Rizzo, Andrias Hojgaard, Sarah E. Maes, Rebecca J. Eisen
Summary: This article describes the prevalence and diversity of Lyme disease in the United States. By using different detection methods, the authors found various species of spirochetes present in specific tick species, revealing the potential transmission of pathogens among ticks.
TICKS AND TICK-BORNE DISEASES
(2024)
Review
Infectious Diseases
El-Sayed El-Alfy, Ibrahim Abbas, Somaya Saleh, Rana Elseadawy, Ragab M. Fereig, Mohamed Abdo Rizk, Xuenan Xuan
Summary: Published data on tick-borne pathogens in camels worldwide have been collected, providing an overview of their global prevalence and species diversity. Evidence of natural infection of camels with certain tick-borne pathogens is limited, particularly because most of the camels were considered healthy at the time of sampling. More research is needed to understand the role of camels in maintaining and transmitting these pathogens.
TICKS AND TICK-BORNE DISEASES
(2024)
Article
Infectious Diseases
Saana Sipari, Mikko Kiljunen, Minna Nylund, Eva R. Kallio
Summary: This study introduces a stable isotope analysis method to directly identify tick breeding hosts by sampling field collected larvae. The results show that stable isotope signatures can reflect the diet of the breeding host of the mother tick.
TICKS AND TICK-BORNE DISEASES
(2024)