Article
Transplantation
Yousif Arif, Cachet Wenziger, Jui Ting Hsiung, Amanda Edward, Wei Ling Lau, Ramy M. Hanna, Yuji Lee, Yoshitsugu Obi, Csaba P. Kovesdy, Kamyar Kalantar-Zadeh, Elani Streja
Summary: This study found that hyperkalemia is associated with a decline in residual kidney function among hemodialysis patients. These findings may have important clinical implications in the management of hyperkalemia in advanced CKD if confirmed in additional clinical trials.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Urology & Nephrology
Soshiro Ogata, Yuumi Akashi, Satoshi Kato, Yuma Oka, Akari Suda, Shigehito Yoshizaki, Yuko Maeda, Kunihiro Nishimura, Kenji Maeda, Shigeru Nakai
Summary: Based on multiple 24-hour urine collections, we investigated the association between 24-hour urinary potassium excretion and serum potassium levels in CKD outpatients. The results showed a significant but weak association between serum potassium levels and dietary potassium intake in CKD patients.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Nutrition & Dietetics
Jiun-Chi Huang, Ya-Chin Huang, Pei-Yu Wu, Wen-Hsien Lee, Yi-Chun Tsai, Yi-Ping Chen, Szu-Chia Chen, Ho-Ming Su, Yi-Wen Chiu, Jer-Ming Chang
Summary: The study revealed a significant association between serum zinc levels and diastolic dysfunction in hemodialysis patients, with lower serum zinc levels increasing the risk of diastolic dysfunction. Diabetes, older age, coronary artery disease, and lower serum zinc levels were identified as important factors contributing to diastolic dysfunction.
Article
Urology & Nephrology
Xunliang Li, Jianping Sun, Quandong Bu, Bin Zhou, Lin Li, Xiaofei Man, Long Zhao, Yan Xu, Hong Luan
Summary: This study investigated the association between serum uric acid (SUA) levels and clinical outcomes in patients with acute kidney injury (AKI). The results showed that elevated SUA levels were associated with increased risk of in-hospital mortality in AKI patients, and it appeared to be an independent prognostic marker for these patients.
Article
Nutrition & Dietetics
Yuewen Sun, Puhong Zhang, Yuan Li, Feng J. He, Jing Wu, Jianwei Xu, Xiaochang Zhang, Xian Li, Jing Song
Summary: The study found that higher sodium intake and Na/K ratio are associated with early renal function impairment in adult Chinese population, while potassium intake did not show a significant association with kidney function measured by albumin excretion.
Article
Nutrition & Dietetics
Sang Heon Suh, Su Hyun Song, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Kook-Hwan Oh, Joongyub Lee, Seung Hyeok Han, Yeong Hoon Kim, Dong-Wan Chae, Seong Kwon Ma, Soo Wan Kim
Summary: In patients with pre-dialysis CKD, low urine potassium excretion is associated with high blood pressure variability and an increased risk of cardiovascular events. Individualized dietary potassium intake restriction is recommended for these patients.
Article
Immunology
Mengyue Zhu, Jingjing Wang, Weibo Le, Feng Xu, Ying Jin, Chenfeng Jiao, Haitao Zhang
Summary: This study investigated the relationship between serum C3 levels and outcomes in patients with anti-GBM disease, and found that patients in the low C3 group had poorer kidney outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Meng-chao Liu, Jia-lin Li, Yue-fen Wang, Yuan Meng, Gui-min Zheng, Zhen Cai, Cun Shen, Meng-di Wang, Xiang-gang Zhu, Yang-zi Chen, Yu-lin Wang, Wen-jing Zhao, Wen-quan Niu, Yao-xian Wang
Summary: This study found that high concentrations of serum complement C4 were significantly associated with an increased risk of kidney function deterioration in all stages of DKD, while reduced serum C3 levels were associated with an increased risk specifically in the G5 stage.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Yukio Maruyama, Masaaki Nakayama, Masanori Abe, Takashi Yokoo, Jun Minakuchi, Kosaku Nitta
Summary: Using a large-scale registry, this study found that serum B2M contributes tenuously but significantly to worse outcomes in peritoneal dialysis patients, and the relationship is significantly affected by residual kidney function.
Article
Medicine, General & Internal
Natsumi Matsuoka-Uchiyama, Kenji Tsuji, Kensaku Takahashi, Kazuhiko Fukushima, Hidemi Takeuchi, Shinji Kitamura, Kenichi Inagaki, Haruhito A. A. Uchida, Jun Wada
Summary: This study examined the association between urinary creatinine excretion rate (CER) and hypothyroidism. The results showed that hypothyroidism was not independently associated with CER, and estimated glomerular filtration rate calculated using serum creatinine (eGFRcre) is a useful marker for evaluating kidney function regardless of hypothyroidism.
Article
Urology & Nephrology
Inga Steinbrenner, Zhi Yu, Jin Jin, Ulla T. Schultheiss, Fruzsina Kotsis, Morgan E. Grams, Josef Coresh, Matthias Wuttke, Florian Kronenberg, Kai-Uwe Eckardt, Nilanjan Chatterjee, Peggy Sekula, Anna Koettgen
Summary: Chronic kidney disease (CKD) is a global health burden affecting over 10% of the adult population. This study aims to investigate the association between a polygenic predisposition to lower eGFR and adverse outcomes in CKD patients, and determine whether it provides additional predictive information beyond established risk factors.
KIDNEY INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Ming-Chun Chen, Chung-Jen Lee, Yu-Li Lin, Chih-Hsien Wang, Bang-Gee Hsu
Summary: This study evaluated the association between serum adiponectin levels and endothelial function in chronic kidney disease (CKD) patients. The results showed that serum adiponectin concentration was positively associated with the vascular reactivity index (VRI), indicating that it can modulate endothelial function in non-dialysis CKD patients.
Article
Cell Biology
Hyo-Jung Lee, Ju-Young Choi, Jaeho Lee, Donghoon Kim, Jin-Young Min, Kyoung-Bok Min
Summary: This study revealed a negative association between serum uric acid and serum klotho levels, indicating that an increase in uric acid levels is associated with a decrease in klotho levels.
Article
Peripheral Vascular Disease
Yuta Matsukuma, Masaru Nakayama, Susumu Tsuda, Akiko Fukui, Ryota Yoshitomi, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono
Summary: This study found that a higher UNa/K ratio was independently associated with poor renal outcomes in patients with chronic kidney disease.
HYPERTENSION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Pardeep S. Jhund, Scott D. Solomon, Kieran F. Docherty, Hiddo J. L. Heerspink, Inder S. Anand, Michael Bohm, Vijay Chopra, Rudolf A. de Boer, Akshay S. Desai, Junbo Ge, Masafumi Kitakaze, Bela Merkley, Eileen O'Meara, Morten Shou, Sergey Tereshchenko, Subodh Verma, Pham Nguyen Vinh, Silvio E. Inzucchi, Lars Kober, Mikhail N. Kosiborod, Felipe A. Martinez, Piotr Ponikowski, Marc S. Sabatine, Olof Bengtsson, Anna Maria Langkilde, Mikaela Sjostrand, John J. McMurray
Summary: The study found that dapagliflozin had consistent safety and efficacy in patients with heart failure and reduced ejection fraction regardless of kidney function status, and it could slow down the decline in eGFR. This effect was observed in patients with and without diabetes.