HTLV-1 Infection and Adult T-Cell Leukemia/Lymphoma—A Tale of Two Proteins: Tax and HBZ

CTCF: making the right connections

(2016) Rodolfo Ghirlando et al.   GENES & DEVELOPMENT

HTLV-1 bZIP factor protein targets the Rb/E2F-1 pathway to promote proliferation and apoptosis of primary CD4+ T cells

(2016) A Kawatsuki et al.   ONCOGENE

The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome

(2016) Yorifumi Satou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanisms of HTLV-1 Cell-to-Cell Transmission

(2016) Christine Gross et al.   Viruses-Basel

HTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing Co-inhibitory Molecule, T Cell Immunoglobulin and ITIM Domain (TIGIT)

(2016) Keiko Yasuma et al.   PLoS Pathogens

HTLV-1 Tax Functions as a Ubiquitin E3 Ligase for Direct IKK Activation via Synthesis of Mixed-Linkage Polyubiquitin Chains

(2016) Chong Wang et al.   PLoS Pathogens

Human T Cell Leukemia Virus Type 1 Infection of the Three Monocyte Subsets Contributes to Viral Burden in Humans

(2015) Maria Fernanda de Castro-Amarante et al.   JOURNAL OF VIROLOGY

Integrated molecular analysis of adult T cell leukemia/lymphoma

(2015) Keisuke Kataoka et al.   NATURE GENETICS

Inducible nitric oxide synthase mediates DNA double strand breaks in Human T-Cell Leukemia Virus Type 1-induced leukemia/lymphoma

(2015) Hicham H Baydoun et al.   Retrovirology

HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation

(2015) Yik-Khuan Ho et al.   PLoS Pathogens

The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma

(2014) L. B. Cook et al.   BLOOD

HTLV-1 bZIP Factor HBZ Promotes Cell Proliferation and Genetic Instability by Activating OncomiRs

(2014) C. Vernin et al.   CANCER RESEARCH

Human T-lymphotropic Virus Type 1-infected Cells Secrete Exosomes That Contain Tax Protein

(2014) Elizabeth Jaworski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NF- B Inhibition Facilitates the Establishment of Cell Lines That Chronically Produce Human T-Lymphotropic Virus Type 1 Viral Particles

(2014) M. A. Zahoor et al.   JOURNAL OF VIROLOGY

KSHV vCyclin counters the senescence/G1 arrest response triggered by NF-κB hyperactivation

(2014) H Zhi et al.   ONCOGENE

Integration Site and Clonal Expansion in Human Chronic Retroviral Infection and Gene Therapy

(2014) Heather Niederer et al.   Viruses-Basel

Regulation of Human T-Lymphotropic Virus Type I Latency and Reactivation by HBZ and Rex

(2014) Subha Philip et al.   PLoS Pathogens

Co-dependence of HTLV-1 p12 and p8 Functions in Virus Persistence

(2014) Cynthia A. Pise-Masison et al.   PLoS Pathogens

HTLV-1 Tax oncoprotein stimulates ROS production and apoptosis in T cells by interacting with USP10

(2013) M. Takahashi et al.   BLOOD

Dma/RNF8 proteins are evolutionarily conserved E3 ubiquitin ligases that target septins

(2013) Richard Chahwan et al.   CELL CYCLE

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

(2013) C. H. Emmerich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HTLV-1 bZIP Factor Induces Inflammation through Labile Foxp3 Expression

(2013) Nanae Yamamoto-Taguchi et al.   PLoS Pathogens

Functional comparison of antisense proteins of HTLV-1 and HTLV-2 in viral pathogenesis

(2013) Benoit Barbeau et al.   Frontiers in Microbiology

Reading, writing, and repair: the role of ubiquitin and the ubiquitin-like proteins in DNA damage signaling and repair

(2013) Jordan B. Pinder et al.   Frontiers in Genetics

Put a RING on it: regulation and inhibition of RNF8 and RNF168 RING finger E3 ligases at DNA damage sites

(2013) Cristina Bartocci et al.   Frontiers in Genetics

HTLV-1-infected T cells contain a single integrated provirus in natural infection

(2012) L. B. Cook et al.   BLOOD

Immune surveillance of senescent cells--biological significance in cancer- and non-cancer pathologies

(2012) L. Hoenicke et al.   CARCINOGENESIS

A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure

(2012) Martijn S Luijsterburg et al.   EMBO JOURNAL

Sumoylation of MDC1 is important for proper DNA damage response

(2012) Kuntian Luo et al.   EMBO JOURNAL

The RING Finger Protein RNF8 Ubiquitinates Nbs1 to Promote DNA Double-strand Break Repair by Homologous Recombination

(2012) Chi-Sheng Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HTLV-1 Tax-Induced Rapid Senescence Is Driven by the Transcriptional Activity of NF- B and Depends on Chronically Activated IKK  and p65/RelA

(2012) Y.-K. Ho et al.   JOURNAL OF VIROLOGY

What we are learning on HTLV-1 pathogenesis from animal models

(2012) Madeleine Duc Dodon et al.   Frontiers in Microbiology

Epidemiological Aspects and World Distribution of HTLV-1 Infection

(2012) Antoine Gessain et al.   Frontiers in Microbiology

Suppression of HTLV-1 replication by Tax-mediated rerouting of the p13 viral protein to nuclear speckles

(2011) V. Andresen et al.   BLOOD

Role of K63-linked polyubiquitination in NF- B signalling: which ligase catalyzes and what molecule is targeted?

(2011) M. Hayakawa   JOURNAL OF BIOCHEMISTRY

Activation of the I B kinase complex by HTLV-1 Tax requires cytosolic factors involved in Tax-induced polyubiquitination

(2011) Y. Shibata et al.   JOURNAL OF BIOCHEMISTRY

Initial genome sequencing and analysis of multiple myeloma

(2011) Michael A. Chapman et al.   NATURE

Making Sense out of Antisense Transcription in Human T-Cell Lymphotropic Viruses (HTLVs)

(2011) Benoit Barbeau et al.   Viruses-Basel

Orf-I and Orf-II-Encoded Proteins in HTLV-1 Infection and Persistence

(2011) Dustin Edwards et al.   Viruses-Basel

HTLV-1 bZIP Factor Induces T-Cell Lymphoma and Systemic Inflammation In Vivo

(2011) Yorifumi Satou et al.   PLoS Pathogens

NF-κB Hyper-Activation by HTLV-1 Tax Induces Cellular Senescence, but Can Be Alleviated by the Viral Anti-Sense Protein HBZ

(2011) Huijun Zhi et al.   PLoS Pathogens

HTLV-I Tax-dependent and -independent events associated with immortalization of human primary T lymphocytes

(2010) M. Bellon et al.   BLOOD

Expanding role of ubiquitination in NF-κB signaling

(2010) Siqi Liu et al.   CELL RESEARCH

The Viral Oncoprotein Tax Sequesters DNA Damage Response Factors by Tethering MDC1 to Chromatin

(2010) S. Mehdi Belgnaoui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Downregulation of CDKN1A in Adult T-Cell Leukemia/Lymphoma despite Overexpression of CDKN1A in Human T-Lymphotropic Virus 1-Infected Cell Lines

(2010) M. Watanabe et al.   JOURNAL OF VIROLOGY

Quantitative Comparison of HTLV-1 and HIV-1 Cell-to-Cell Infection with New Replication Dependent Vectors

(2010) Dmitriy Mazurov et al.   PLoS Pathogens

The HTLV-1 Tax protein: Revealing mechanisms of transcriptional activation through histone acetylation and nucleosome disassembly

(2009) Jennifer K. Nyborg et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

HTLV-1-Tax and ICAM-1 act on T-cell signal pathways to polarize the microtubule-organizing center at the virological synapse

(2009) M. Nejmeddine et al.   BLOOD

HTLV-1 uses HSPG and neuropilin-1 for entry by molecular mimicry of VEGF165

(2009) S. Lambert et al.   BLOOD

Proviral Loads and Clonal Expansion of HTLV-1-Infected Cells following Vertical Transmission: A 10-Year Follow-Up of Children in Jamaica

(2009) Kazumi Umeki et al.   INTERVIROLOGY

Kinetic Analysis of Human T-Cell Leukemia Virus Type 1 Gene Expression in Cell Culture and Infected Animals

(2009) M. Li et al.   JOURNAL OF VIROLOGY

DC-SIGN Mediates Cell-Free Infection and Transmission of Human T-Cell Lymphotropic Virus Type 1 by Dendritic Cells

(2009) P. Jain et al.   JOURNAL OF VIROLOGY

Biofilm-like extracellular viral assemblies mediate HTLV-1 cell-to-cell transmission at virological synapses

(2009) Ana-Monica Pais-Correia et al.   NATURE MEDICINE

The HBZ gene, a key player in HTLV-1 pathogenesis

(2009) Masao Matsuoka et al.   Retrovirology

Induction of p21CIP1/WAF1 expression by human T-lymphotropic virus type 1 Tax requires transcriptional activation and mRNA stabilization

(2009) Ling Zhang et al.   Retrovirology

The NF-κB-independent functions of IKK subunits in immunity and cancer

(2009) Alain Chariot   TRENDS IN CELL BIOLOGY

Human T-cell leukemia virus type-1 antisense-encoded gene, Hbz, promotes T-lymphocyte proliferation

(2008) J. Arnold et al.   BLOOD

Human T-cell leukemia virus type 1 bZIP factor selectively suppresses the classical pathway of NF- B

(2008) T. Zhao et al.   BLOOD

HTLV-1 Tax Oncoprotein Subverts the Cellular DNA Damage Response via Binding to DNA-dependent Protein Kinase

(2008) Sarah S. Durkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Interaction between the Human T Cell Leukemia Virus Type 1 Basic Leucine Zipper Factor (HBZ) and the KIX Domain of p300/CBP Contributes to the Down-regulation of Tax-dependent Viral Transcription by HBZ

(2008) Isabelle Clerc et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Definition, Prognostic Factors, Treatment, and Response Criteria of Adult T-Cell Leukemia-Lymphoma: A Proposal From an International Consensus Meeting

(2008) Kunihiro Tsukasaki et al.   JOURNAL OF CLINICAL ONCOLOGY

Upregulation of Human T-Cell Leukemia Virus Type 1 Antisense Transcription by the Viral Tax Protein

(2008) S. Landry et al.   JOURNAL OF VIROLOGY

Transcriptional Control of Spliced and Unspliced Human T-Cell Leukemia Virus Type 1 bZIP Factor (HBZ) Gene

(2008) M. Yoshida et al.   JOURNAL OF VIROLOGY

Human T-Cell Leukemia Virus Type 1 Infection Leads to Arrest in the G1 Phase of the Cell Cycle

(2008) M. Liu et al.   JOURNAL OF VIROLOGY

Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4+ T cells

(2008) Kathryn S Jones et al.   NATURE MEDICINE

HTLV-1 Integration into Transcriptionally Active Genomic Regions Is Associated with Proviral Expression and with HAM/TSP

(2008) Kiran N. Meekings et al.   PLoS Pathogens