A Systematic Review of the Definitions, Determinants, and Clinical Outcomes of Antimicrobial De-escalation in the Intensive Care Unit

A Simulation Study Reveals Lack of Pharmacokinetic/Pharmacodynamic Target Attainment in De-escalated Antibiotic Therapy in Critically Ill Patients

(2015) Mieke Carlier et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Elaboration of a consensual definition of de-escalation allowing a ranking of β-lactams

(2015) E. Weiss et al.   CLINICAL MICROBIOLOGY AND INFECTION

Antimicrobial de-escalation in septic cancer patients: is it safe to back down?

(2015) Alla Paskovaty et al.   INTENSIVE CARE MEDICINE

Development of an Antibiotic Spectrum Score Based on Veterans Affairs Culture and Susceptibility Data for the Purpose of Measuring Antibiotic De-Escalation: A Modified Delphi Approach

(2014) Karl Madaras-Kelly et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

De-escalation versus continuation of empirical antimicrobial treatment in severe sepsis: a multicenter non-blinded randomized noninferiority trial

(2014) Marc Leone et al.   INTENSIVE CARE MEDICINE

Emergence of Imipenem-Resistant Gram-Negative Bacilli in Intestinal Flora of Intensive Care Patients

(2013) Laurence Armand-Lefèvre et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012

(2013) R. P. Dellinger et al.   INTENSIVE CARE MEDICINE

De-escalation of antimicrobial treatment in neutropenic patients with severe sepsis: results from an observational study

(2013) Djamel Mokart et al.   INTENSIVE CARE MEDICINE

De-escalation of empirical therapy is associated with lower mortality in patients with severe sepsis and septic shock

(2013) J. Garnacho-Montero et al.   INTENSIVE CARE MEDICINE

Antibiotic strategies in severe nosocomial sepsis

(2012) Sarah Heenen et al.   CRITICAL CARE MEDICINE

De-escalation after empirical meropenem treatment in the intensive care unit: Fiction or reality?

(2010) Jan J. De Waele et al.   JOURNAL OF CRITICAL CARE

Does De-Escalation of Antibiotic Therapy for Ventilator-Associated Pneumonia Affect the Likelihood of Recurrent Pneumonia or Mortality in Critically Ill Surgical Patients?

(2009) Soumitra R. Eachempati et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE