Article
Infectious Diseases
Marta Palombo, Federica Bovo, Stefano Amadesi, Paolo Gaibani
Summary: Limited treatment options contribute to the emergence of antimicrobial resistance, and new therapeutic agents are needed for the treatment of certain pathogens. The combination of antibiotics is an effective strategy to combat multidrug-resistant infections.
Article
Multidisciplinary Sciences
Christina Medhat Naiim, M. M. Elmazar, Nagwa A. Sabri, Naglaa S. Bazan
Summary: This study compared the efficacy, safety, and cost-effectiveness between extended infusion and intermittent infusion of piperacillin/tazobactam in the treatment of gram-negative bacterial infections. The results demonstrated that extended infusion had shorter treatment duration and time to clinical success compared to intermittent infusion, and it was more cost-effective. Both regimens had comparable clinical and microbiological outcomes.
SCIENTIFIC REPORTS
(2022)
Article
Infectious Diseases
Ayan Ali Ragueh, Mohamed Houmed Aboubaker, Sitani Idriss Mohamed, Jean-Marc Rolain, Seydina M. Diene
Summary: This study investigated the resistance rate to carbapenems among multidrug-resistant Gram-negative bacteria (MDR-GNB) in Djibouti and characterized their resistance mechanisms. The results showed that out of 256 isolates, 20 were resistant to carbapenems. Carbapenemase genes such as bla(OXA-48) and bla(NDM-5) were identified in the isolates.
Article
Microbiology
Carmen Antonia Sanches Ito, Larissa Bail, Lavinia Nery Villa Stangler Arend, Kleber Oliveira Silva, Simone Sebold Michelotto, Keite da Silva Nogueira, Felipe Francisco Tuon
Summary: The study evaluated the performance of a new MicroScan Neg multidrug-resistant MIC 1 (NMR1) panel for clinical carbapenem-nonsusceptible Gram-negative bacilli isolates, demonstrating high reliability in detecting ceftazidime-avibactam and ceftolozane-tazobactam. The panel is a viable option for clinical applications, especially for KPC-producing Enterobacterales and carbapenem-nonsusceptible P. aeruginosa.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Infectious Diseases
Jihyun Yang, Yoon Sook Ko, Hee Young Lee, Yina Fang, Se Won Oh, Myung-Gyu Kim, Won Yong Cho, Sang-Kyung Jo
Summary: Piperacillin/tazobactam (PT) is commonly used in intensive care for critically ill patients, but the mechanisms of its nephrotoxicity are unclear. This study demonstrated that PT directly induces oxidative stress and mitochondrial damage in renal tubular cells, suggesting a direct nephrotoxic effect.
Article
Immunology
John Cao, Yanina Dubrovskaya, Justin Siegfried, Arnold Decano, Dana Mazo, Sarah Hochman, Ioannis M. Zacharioudakis, Jonathan So, Sadie Solomon, John Papadopoulos, Kassandra Marsh
Summary: This retrospective study compared the treatment strategies for TZP-NS/CRO-S E coli or K pneumoniae infections in noncritically ill adults. The results showed no significant difference in clinical outcomes between patients who received carbapenem and those who received carbapenem-sparing agents.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Microbiology
Yuvaneswary Veloo, Syahidiah S. A. Thahir, Sakshaleni Rajendiran, Lim K. Hock, Norazah Ahmad, Vickneshwaran Muthu, Rafiza Shaharudin
Summary: The indiscriminate use of antibiotics in poultry farming has led to the emergence of antibiotic-resistant bacteria in poultry products and the surrounding environment. This study found high rates of multidrug-resistant Gram-negative bacteria in the environment of poultry farms, with some strains exhibiting resistance to multiple antibiotics. The presence of these bacteria poses a significant threat to the effectiveness of available antibiotics in treating infectious diseases. Efforts to regulate antibiotic use and conduct research on One Health issues are necessary to combat and prevent the spread of antibiotic-resistant bacteria.
MICROBIOLOGY SPECTRUM
(2022)
Article
Infectious Diseases
Widad Chelaghma, Lotfi Loucif, Esma Bendjama, Zineb Cherak, Mourad Bendahou, Jean-Marc Rolain
Summary: This study aimed to screen for antibiotic-resistant Gram-negative bacteria in fresh vegetables in Batna, Algeria. The results revealed the presence of multiple antibiotic-resistant strains, with E. coli showing the highest level of antibiotic resistance. The detection of bla(OXA-48) and mcr-1 genes in E. coli and C. braakii isolates is noteworthy.
Article
Public, Environmental & Occupational Health
Hessa Al Muqati, Abdulrahman Al Turaiki, Fahad Al Dhahri, Huda Al Enazi, Abdullah Althemery
Summary: In this study, patients with higher risk of superinfection were typically those with tracheostomy, endotracheal ventilation, Foley catheter, and longer duration of antibiotic treatment.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Article
Infectious Diseases
Jose Raul Nieto-Saucedo, Luis Esau Lopez-Jacome, Rafael Franco-Cendejas, Claudia Adriana Colin-Castro, Melissa Hernandez-Duran, Luis Raul Rivera-Garay, Karina Senyase Zamarripa-Martinez, Juan Luis Mosqueda-Gomez
Summary: The prevalence of carbapenem-resistant Gram-negative bacilli (CR-GNB) and the frequency of carbapenemase-encoding genes were evaluated in a tertiary referral center in El Bajio, Mexico. Among 508 Gram-negative bacilli, 37 were carbapenem-resistant (7.3%), and only 15 (40.5%) of them carried carbapenemase-encoding genes.
Article
Infectious Diseases
Pasquale Maria Berrino, Milo Gatti, Matteo Rinaldi, Eugenio Brunocilla, Pierluigi Viale, Federico Pea
Summary: This study explores the relationship between pharmacokinetic/pharmacodynamic (PK/PD) target attainment of continuous infusion (CI) piperacillin-tazobactam or meropenem monotherapy and microbiological outcome in urological patients with Gram-negative infections. The results demonstrate that optimizing beta-lactam treatment through real-time therapeutic drug monitoring (TDM)-guided expert clinical pharmacological advice (ECPA) program can achieve microbiological eradication in most cases.
Review
Immunology
Flora Cruz-Lopez, Adrian Martinez-Melendez, Rayo Morfin-Otero, Eduardo Rodriguez-Noriega, Hector J. Maldonado-Garza, Elvira Garza-Gonzalez
Summary: Infections caused by Gram-negative multi-drug resistant (MDR) bacterial species are difficult to treat due to widespread antibiotic resistance. New antibiotics and combinations with existing drugs have shown potential in treating these infections, but there are reports of resistance to these treatments.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Malgorzata Brauncajs, Filip Bielec, Anna Macieja, Dorota Pastuszak-Lewandoska
Summary: Gram-negative fermenting and non-fermenting bacteria, especially those that produce carbapenemases, are important etiological factors of nosocomial and community infections. New antibiotics and treatment regimens offer hope against these infections.
Article
Infectious Diseases
Mariam Rima, Saoussen Oueslati, Laura Dabos, Dina Daaboul, Hassan Mallat, Elie Bou Raad, Marcel Achkar, Osman Mawlawi, Sandrine Bernabeu, Remy A. Bonnin, Delphine Girlich, Marwan Osman, Monzer Hamze, Thierry Naas
Summary: This study investigated the prevalence of carbapenem-resistant Gram-negative bacilli (CR-GNB) in three hospitals in northern Lebanon between 2015 and 2019. The findings highlighted a concerning situation of carbapenem resistance and emphasized the need for effective registration systems in healthcare centers to limit resistance spread.
Article
Pharmacology & Pharmacy
Christian M. Gill, David P. Nicolau
Summary: This study evaluates the potency of piperacillin/tazobactam against carbapenem-resistant Pseudomonas aeruginosa (CR-PA) and assesses the adequacy of the CLSI P aeruginosa breakpoint dose for CR-PA using Monte Carlo simulation. The results suggest that higher doses and extended infusion of piperacillin/tazobactam are needed to optimize exposure for susceptible CR-PA isolates. The findings have implications for the use of piperacillin/tazobactam in the treatment of CR-PA. Rating: 8.5 out of 10.
CLINICAL THERAPEUTICS
(2023)
Article
Public, Environmental & Occupational Health
Lona Mody, Ibukunoluwa C. Akinboyo, Hilary M. Babcock, Werner E. Bischoff, Vincent Chi-Chung Cheng, Kathleen Chiotos, Kimberly C. Claeys, K. C. Coffey, Daniel J. Diekema, Curtis J. Donskey, Katherine D. Ellingson, Heather M. Gilmartin, Shruti K. Gohil, Anthony D. Harris, Sara C. Keller, Eili Y. Klein, Sarah L. Krein, Jennie H. Kwon, Adam S. Lauring, Daniel J. Livorsi, Eric T. Lofgren, Katreena Merrill, Aaron M. Milstone, Elizabeth A. Monsees, Daniel J. Morgan, Luci P. Perri, Christopher D. Pfeiffer, Clare Rock, Sanjay Saint, Emily Sickbert-Bennett, Felicia Skelton, Katie J. Suda, Thomas R. Talbot, Valerie M. Vaughn, David J. Weber, Timothy L. Wiemken, Mohamed H. Yassin, Matthew J. Ziegler, Deverick J. Anderson
Summary: This white paper identifies knowledge gaps and challenges in healthcare epidemiology research related to COVID-19 and proposes a research agenda. It emphasizes the need for collaboration across disciplines and addresses issues related to nursing homes and social disparities.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Katherine D. Ellingson, Brie N. Noble, Genevieve L. Buser, Graham M. Snyder, Jessina C. McGregor, Clare Rock, Teena Chopra, Lona Mody, Jon P. Furuno
Summary: Most hospitals have interfacility transfer communication (IFTC) protocols in place, which are associated with reduced communication barriers. However, most respondents reported a lack of standardization in communication protocols.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Sara C. Keller, Sara Pau, Alejandra B. Salinas, Opeyemi Oladapo-Shittu, Sara E. Cosgrove, Robin Lewis-Cherry, Briana Vecchio-Pagan, Patience Osei, Ayse P. Gurses, Clare Rock, Anna C. Sick-Samuels
Summary: This qualitative study observed healthcare workers' activities and interactions in a medical unit, identifying high-risk interactions during patient handoffs and rounds. Barriers to physical distancing included computer workstation availability and the need to communicate confidential patient information. Recommendations to improve physical distancing in hospitals include restructuring workstations, using visible cognitive aids, adjusting shift times, and supporting virtual meetings. Additional strategies to promote staff adherence to physical distancing include rewarding positive behaviors and providing safe avenues for social connection.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Review
Immunology
Emily J. Curren, Joseph D. Lutgring, Sarah Kabbani, Daniel J. Diekema, Steven Gitterman, Ebbing Lautenbach, Daniel J. Morgan, Clare Rock, Reynolds M. Salerno, L. Clifford McDonald
Summary: Diagnostic stewardship is the practice of ordering appropriate tests for the right patient at the right time in order to optimize antibiotic use and improve patient outcomes. A meeting hosted by the Centers for Disease Control and Prevention focused on patient safety through diagnostic stewardship, identifying emerging issues, raising awareness among stakeholders, and discussing strategies and interventions to address these issues.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Leigh Smith, Sara Pau, Susan Fallon, Sara E. Cosgrove, Melanie S. Curless, Valeria Fabre, Sara M. Karaba, Lisa L. Maragakis, Aaron M. Milstone, Anna C. Sick-Samuels, Polly Trexler, Clare Rock
Summary: This study analyzed the impact of a 7-day recurring asymptomatic SARS-CoV-2 testing protocol for all hospitalized patients in a large academic center. The results showed that 40 new cases were identified, with 1 out of 3 cases occurring after 14 days of hospitalization. Recurring testing can effectively identify unrecognized infections, especially during periods of high community transmission.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Immunology
Clare Rock, Yea-Jen Hsu, Melanie S. Curless, Karen C. Carroll, Tracy Ross Howard, Kathryn A. Carson, Stephanie Cummings, Michael Anderson, Aaron M. Milstone, Lisa L. Maragakis
Summary: The study found that using UV-C light disinfection daily and at discharge in addition to standard environmental cleaning did not reduce the transmission rates of C. difficile and VRE in cancer and solid organ transplant units.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Clare Rock, Oluchi Abosi, Susan Bleasdale, Erin Colligan, Daniel J. Diekema, Prashila Dullabh, Ayse P. Gurses, Krysta Heaney-Huls, Jesse T. Jacob, Sheetal Kandiah, Sonam Lama, Surbhi Leekha, Jeanmarie Mayer, Alfredo J. Mena Lora, Daniel J. Morgan, Patience Osei, Sara Pau, Jorge L. Salinas, Emily Spivak, Eric Wenzler, Sara E. Cosgrove
Summary: Computerized clinical decision support (CCDS) systems can reduce unnecessary Clostridioides difficile testing and are positively perceived by healthcare providers when integrated into their workflow and providing relevant patient-specific information.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Anna C. Sick-Samuels, Sara Cosgrove, Clare Rock, Alejandra Salinas, Opeyemi Oladapo-Shittu, Ayse P. Gurses, Briana Vecchio-Pagan, Patience Osei, Yea-Jen Hsu, Ron Jacak, Kristina K. Zudock, Kianna M. Blount, Kenneth Bowden, Sara Keller
Summary: The study assessed the impact of interventions to improve healthcare workers' physical distancing in a pediatric intensive care unit, finding a small decline in interactions within 6 feet after implementing a bundle of interventions.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Article
Geriatrics & Gerontology
Morgan J. Katz, Christopher D. Heaney, Nora Pisanic, Leigh Smith, Benjamin F. Bigelow, Fatima Sheik, Alec Boudreau, Kate Kruczynski, Yea-Jen Hsu, Alejandra B. Salinas, Sara E. Cosgrove, Clare Rock
Summary: This study aimed to evaluate salivary IgG antibodies in residents and staff of a long-term care facility, and to assess the seroprevalence over time. The results showed that saliva IgG antibodies were concordant with prior infection and vaccination, and remained detectable for up to 9 months from infection. Salivary sampling is a non-invasive method that can track immunity and differentiate between prior infection and vaccination, which can inform the need for boosters in long-term care residents and staff.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Gastroenterology & Hepatology
Robert A. Moran, Christopher Halloran, Qiang Guo, Chandra Umapathy, Niloofar Y. Jalaly, Saransh Jain, Darren Cowzer, Enrique Perez Cuadrado Robles, Noe Quesada-Vaszquez, Andrea Szentesi, Maria Papp, Tiffany Chua, Katalin Marta, Kartik Sampath, David X. Jin, Shaheel Mohammad Sahebally, Tobias Philipp Kuschnereit, Mouen A. Khashab, Clare Rock, Erika Darvasi, Rebecca Saunders, Guillermo Garcia-Rayado, Yolanda Sanchez Torrijos, Laoise Coady, Georgios I. Papachristou, Julia Mayerle, Justin Geoghegan, Peter A. Banks, Timothy B. Gardner, Aniko Nora Szabo, Tyler Stevens, Tamas Tornai, Emese Toth, Gerry McEntee, Enrique de-Madaria, Pramod K. Garg, Peter Hegyi, Dhiraj Yadav, Weiming Hu, John Neoptolemos, Vikesh K. Singh
Summary: Early infection in infected pancreatic necrosis is associated with increased mortality. Early surgery remains a significant predictor of excess mortality.
Article
Health Care Sciences & Services
Clare Rock, Rebecca Perlmutter, David Blythe, Jacqueline Bork, Kimberly Claeys, Sara E. Cosgrove, Kate Dzintars, Valeria Fabre, Anthony D. Harris, Emily Heil, Yea-Jen Hsu, Sara Keller, Lisa L. Maragakis, Aaron M. Milstone, Daniel J. Morgan, Prashila Dullabh, Petry S. Ubri, Christina Rotondo, Richard Brooks, Surbhi Leekha
Summary: The study evaluated changes in Clostridioides difficile incidence rates for Maryland hospitals participating in the SPARC collaborative, showing that hospitals in the intervention group experienced a 45% greater reduction in C. difficile rates compared to control hospitals. Key activities of the SPARC project, such as access to experts, technical assistance, and peer-to-peer learning, were associated with positive experiences and outcomes in reducing hospital-acquired infections.
BMJ QUALITY & SAFETY
(2022)
Article
Public, Environmental & Occupational Health
L. McKinley, C. C. Goedken, E. Balkenende, G. Clore, Sherlock S. Hockett, R. Bartel, S. Bradley, J. Judd, Goedken Lyons, C. Rock, M. Rubin, C. Shaughnessy, H. S. Reisinger, E. Perencevich, N. Safdar
Summary: This study used a mixed methods approach to examine daily environmental cleaning practices in healthcare facilities. The results revealed low cleaning rates, especially in the presence of patients and in semi-private rooms. Standardized cleaning practices are needed to address these barriers and improve cleaning rates.
AMERICAN JOURNAL OF INFECTION CONTROL
(2023)
Article
Public, Environmental & Occupational Health
Leigh Smith, C. Paul Morris, Morgan H. Jibowu, Susan Fallon, Stuart C. Ray, Sara E. Cosgrove, Melanie S. Curless, Valeria Fabre, Sara M. Karaba, Lisa L. Maragakis, Aaron M. Milstone, Anna C. Sick-Samuels, Polly Trexler, Heba H. Mostafa, Clare Rock
Summary: This passage discusses the challenges of confirming the transmission of SARS-CoV-2 among healthcare workers and hospitalized patients, as well as the potential risk factors identified through investigation.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Helen L. Zhang, Kyle J. Gontjes, Jennifer H. Han, Kevin Alby, Zena Lapp, Evan Snitkin, Ellie J. C. Goldstein, Sean Muldoon, Pam Tolomeo, Ebbing Lautenbach
Summary: This study assessed the susceptibility patterns of clinical carbapenem-resistant Klebsiella pneumoniae isolates from patients in long-term acute-care hospitals to newer antimicrobial agents. The results showed high levels of nonsusceptibility to meropenem-vaborbactam and imipenem-relebactam, while nonsusceptibility to ceftazidime-avibactam and plazomicin was less common.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Immunology
Krista Moore, Ebbing Lautenbach, Emily A. Blumberg, Jennifer Han, Dong Heun Lee, Heather Clauss, Richard Hasz, Warren B. Bilker, Esther Molnar, Darcy Alimenti, Sharon West, Pam Tolomeo, Judith A. Anesi
Summary: This study found that deceased organ donors with recent injection drug use were more likely to have positive culture results, but their outcomes did not affect the recipients, suggesting that organs from donors with recent injection drug use may be safely used.
TRANSPLANT INFECTIOUS DISEASE
(2022)